Interdependence of urinary factors in calcareous bladder stone patients

Abstract

Twenty-four-hour urinary excretion of calcium, oxalic acid, inorganic phosphorus, magnesium and citric acid was examined in fifty-nine stone formers with bladder stones. Hypercalciuria and hyperoxaluria were present in 18.6% and 44.1%, respectively, while 11.9% of patients had both abnormalities. Hypomagnesuria and hypocitraturia were present in 67.8% and 69.5%, respectively, while 45.7% had both of these abnormalities. Normal urine chemistry in respect of parameters studied was observed only in 1.7% of cases. In 15.2% one risk factor was present, while 83.1% had two or more risk factors. "Path" analysis of the urinary parameters directly related to calcium lithiasis showed that magnesium and oxalic acid have substantial influence on calcium excretion, whereas citric acid had none. The influence of phosphorus did not provide any consistent trend.

Recurrent vesical calculi, hypercalciuria and biochemical evidence of increased bone resorption in an adult male with paraplegia due to spinal cord injury: is there a role for intermittent oral disodium etidronate therapy for prevention of calcium phosphate bladder stones?

“…Of the 59 patients, one risk factor was present in 15.2% of patients, while 83.1% had two or more risk factors. 3 Bisphosphonates inhibit calcium oxalate crystal growth in vitro. Older-and newer-generation bisphosphonates inhibited calcium oxalate vesical lithiasis in male Sprague-Dawley rats, and the inhibitory effect of bisphosphonates was demonstrable at relatively infrequent dosing intervals in vivo.…”