Interdependency of
            <i>NINJ2</i>
            gene expression and polymorphism with susceptibility and response to interferon beta in patients with multiple sclerosis

Khorrami, Mehdi; Saneipour, Maryam; Moridnia, Abbas; Shaygannejad, Vahid; Sadeghi, Erfan; Kassani, Aziz; Sarmadi, Akram; Mirmosayyeb, Omid

doi:10.1080/00207454.2022.2102979

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…The analyses further revealed that this association is mainly related to the time of occurrence of clinical inflammatory activity (time to first relapse, rs7298096 AA : hazard ratio = 1.41, p = 3 × 10 −4 ) [ 6 ], suggesting that this SNP and NINJ2 are involved in the inflammatory component of the disease. This association was confirmed in a more recent study demonstrating that NINJ2 gene expression is higher in non-responders compared to responder IFN-β-treated MS patients [ 8 ].…”

Section: Introductionsupporting

confidence: 59%

Involvement of NINJ2 Protein in Inflammation and Blood–Brain Barrier Transmigration of Monocytes in Multiple Sclerosis

Sorosina

Peroni

Mascia

et al. 2022

Genes

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Multiple sclerosis (MS) is an inflammatory neurodegenerative disorder of the central nervous system (CNS). The migration of immune cells into the CNS is essential for its development, and plasma membrane molecules play an important role in triggering and maintaining the inflammation. We previously identified ninjurin2, a plasma membrane protein encoded by NINJ2 gene, as involved in the occurrence of relapse under Interferon-β treatment in MS patients. The aim of the present study was to investigate the involvement of NINJ2 in inflammatory conditions and in the migration of monocytes through the blood–brain barrier (BBB). We observed that NINJ2 is downregulated in monocytes and in THP-1 cells after stimulation with the pro-inflammatory cytokine LPS, while in hCMEC/D3 cells, which represent a surrogate of the BBB, LPS stimulation increases its expression. We set up a transmigration assay using an hCMEC/D3 transwell-based model, finding a higher transmigration rate of monocytes from MS subjects compared to healthy controls (HCs) in the case of an activated hCMEC/D3 monolayer. Moreover, a positive correlation between NINJ2 expression in monocytes and monocyte migration rate was observed. Overall, our results suggest that ninjurin2 could be involved in the transmigration of immune cells into the CNS in pro-inflammatory conditions. Further experiments are needed to elucidate the exact molecular mechanisms.

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Section: Introductionsupporting

confidence: 59%

Involvement of NINJ2 Protein in Inflammation and Blood–Brain Barrier Transmigration of Monocytes in Multiple Sclerosis

Sorosina

Peroni

Mascia

et al. 2022

Genes

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Effects of Ninjurin 2 polymorphisms on susceptibility to coronary heart disease

Yan,

Du,

Dou

et al. 2024

Cell Cycle

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Objective The aim of this study was to explore the effects of NINJ2 polymorphisms on susceptibility of coronary heart disease (CHD). Methods We conducted a case-control study with 499 CHD cases and 505 age-and sex-matched controls. Five single nucleotide polymorphisms (SNP) in NINJ2 (rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368) were genotyped by Agena MassARRAY platform. Odd ratios (OR) and 95% con dence intervals (CI) were calculated using logistic regression to assess the association of NINJ2 polymorphism and CHD risk adjusting for age and gender.. Results NINJ2 rs118050317 signi cantly increased CHD risk among people older than 60 years old

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Interferon beta-1a sc at 25 years: a mainstay in the treatment of multiple sclerosis over the period of one generation

Zettl,

Rommer,

Aktas

et al. 2023

Expert Review of Clinical Immunology

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Interdependency of NINJ2 gene expression and polymorphism with susceptibility and response to interferon beta in patients with multiple sclerosis

Cited by 3 publications

References 17 publications

Involvement of NINJ2 Protein in Inflammation and Blood–Brain Barrier Transmigration of Monocytes in Multiple Sclerosis

Involvement of NINJ2 Protein in Inflammation and Blood–Brain Barrier Transmigration of Monocytes in Multiple Sclerosis

Effects of Ninjurin 2 polymorphisms on susceptibility to coronary heart disease

Interferon beta-1a sc at 25 years: a mainstay in the treatment of multiple sclerosis over the period of one generation

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