Interdigital Involvement in a Case of Primary Cutaneous Canine Histoplasmosis in Japan

Nishifuji, Koji; Ueda, Yachiyo; Sano, Ayako; Kadoya, Masato; Kamei, Katsuhiko; Sekiguchi, Mitsuhiro; Nishimura, Kazuko; Iwasaki, T.

doi:10.1111/j.1439-0442.2005.00763.x

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…In Japan, the former studies demonstrated that canine histoplasmosis could be cutaneous in origin, including dogs with surgical wounds contaminated with the organism [11] , [12] . Moreover, the preceding studies found that cutaneous lesions of histoplasmosis were confined to the interdigital regions of the dog's paws [13] , [14] . These case reports might support that H. capsulatum was possible to infect animals via percutaneous inoculation.…”

Section: Discussionmentioning

confidence: 97%

Feline cutaneous histoplasmosis: The first case report from Thailand

Larsuprom

Duangkaew

Kasorndorkbua

et al. 2017

Medical Mycology Case Reports

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A 2-year-old, neutered female domestic shorthaired cat presented with a history of multiple papules and nodules on pinnae, nodules on the nose, and chronic wound at the lateral surface of left radial area for four months. Skin biopsy demonstrated moderate numbers of small, oval-to-round, single-walled yeasts inside the macrophages. In addition, PCR confirmed the sequence of Histoplasma capsulatum. This is the first case report of feline cutaneous histoplasmosis in Thailand.

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Section: Discussionmentioning

confidence: 97%

Feline cutaneous histoplasmosis: The first case report from Thailand

Larsuprom

Duangkaew

Kasorndorkbua

et al. 2017

Medical Mycology Case Reports

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“…Recently, however, autochthonous cases have been reported in humans [13]. Seven cases of canine histoplasmosis have been reported in Japan [12,17,18,20,22]. In addition, Murata et al have compared canine cases with worldwide human and equine cases with respect to partial sequences on the internal transcribed spacer (ITS1/ 2) regions of the ribosomal DNA genes [17].…”

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confidence: 99%

First Case Report of Histoplasmosis in a Cat in Japan

Kobayashi

Tanaka²,

Asai³

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Cytological, histopathological and immunohistochemical examinations were carried out on a presumed 10-year-old Japanese cat showing vomiting and emaciation. On cytologic examination of the mass of the upper abdominal cavity, many yeast-like organisms were detected in the macrophages. At necropsy, the upper part of colon was markedly dilated with a thickened wall. The lung did not show significant changes. Histologically, severe necrotic and granulomatous lesions were observed in the colon. In the colonic lesion, the cytoplasm of the macrophages contained yeast-like organisms with irregularly shaped dots, and the cell walls of these organisms were stained black by Grocott-Gomori methenamine-silver stain. Immunohistochemically, they were found to be positive for anti-histoplasma yeast antibody. This is the first report of feline histoplasmosis in Japan.

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“…In addition, the detection of the gene sequence from the pus sample of case 1 and the coincidence of the sequences between the tissue and the pus samples of the previously reported case by Nishifuji et al . [9] indicate that a pus sample obtained non-invasively can be useful and adequate for the molecular biological diagnosis of histoplasmosis.…”

Section: Discussionmentioning

confidence: 98%

“…Detection limit of nested PCR for the ITS1/2 region of H. capsulatum using DNA from pus[9]. M, marker; 1, DNA from pus; 2, fungal DNA at 2.5 ng; 3, 250 fg; 4, 25 fg; 5, 2.5 fg; and 6, negative control.…”

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confidence: 99%

Molecular epidemiology of canine histoplasmosis in Japan

Murata¹,

Sano²,

Ueda³

et al. 2007

Med Mycol

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A recent case of canine histoplasmosis, the first confirmed case of disseminated infection accompanied by carcinoma in Japan, was diagnosed by clinical characteristics, histopathological examination, chest radiographs, ocular fundoscopy and molecular biological data. The clinical manifestations were not limited to cutaneous symptoms but were referable to disseminated infection, similar to human autochthonous cases. The partial sequences of the internal transcribed spacer (ITS1/2) regions of the ribosomal DNA genes of this and other Japanese canine histoplasmosis strains were 99-100% identical to the sequence AB211551 derived from a human isolate in Thailand, and showed a close relationship to the sequences derived from Japanese autochthonous systemic and cutaneous human cases. The phylogenetic analysis of 97 sequences of the ITS1/2 region disclosed six genotypes. The genotypes derived from Japanese autochthonous human and dog cases belonged to the cluster consisting of Histoplasma capsulatum var. capsulatum and H. capsulatum var. farciminosum sequences, indicating that these varieties might cause not only cutaneous but also systemic histoplasmosis, regardless of their host species. The current status of the 3 varieties of Histoplasma capsulatum according to the host species remains a subject of further investigation.

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Interdigital Involvement in a Case of Primary Cutaneous Canine Histoplasmosis in Japan

Cited by 8 publications

References 13 publications

Feline cutaneous histoplasmosis: The first case report from Thailand

Feline cutaneous histoplasmosis: The first case report from Thailand

First Case Report of Histoplasmosis in a Cat in Japan

Molecular epidemiology of canine histoplasmosis in Japan

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