Interdigitating dendritic cell sarcoma located in the groin: a case report and literature review

Wang, Hong-Tao; Xu, Hongpeng; Zhang, Rong; Liu, Zhuogang; Zhang, Guojun

doi:10.1177/0300060518792444

Cited by 10 publications

(4 citation statements)

References 35 publications

(119 reference statements)

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“…For localized foci, surgical resection or adjuvant radiotherapy is preferred, and IDCS with multiple systemic metastases usually displays a poor prognosis. [ 10 ] Based on the Cox regression model, surgical resection is the only treatment associated with improved survival. The 1-year mortality rates in resected and non-resected disease were 17.8% and 63.2%, respectively ( P < .01).…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal dendritic cell sarcoma

Wang¹,

Lei

Wan³

et al. 2021

Medicine

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Ratioanle: Interdigitating dendritic cell sarcoma (IDCS) is a rare sarcoma that originates from interdigitating dendritic cells in lymphoid tissue, the imaging characteristics of which are poorly defined. Pathological examination can identify the tumor, but reports on the imaging characteristics of IDCS are limited. Patient concerns: Here, we report a case of IDCS in a 48-year-old female involving the retroperitoneal area. The patient had a lumbar mass on her right lower back for 4 years, and which started increasing in size 1 year before. Diagnoses: An irregular soft tissue mass (10.1cm × 8.5 cm in size) in the right lower back of retroperitoneum was detected by CT examination with unclear borders, uneven density, and necrosis. The solid components of the mass were significantly enhanced on postcontrast imaging. The soft tissue was irregular and uneven. Cystic solid masses were observed on MRI examination in the right retroperitoneum, lateral abdominal wall, waist, and back. Necrosis, hemorrhage, and cystic transformation were observed inside the lesion. The cyst wall, separation, and wall nodules were significantly enhanced on the postcontrast image. No distant metastasis was observed. Postoperative pathology confirmed the diagnosis of IDCS. Interventions: The patient underwent surgical resection. The resected margin was positive, and the patient received adjuvant radiotherapy 2 months after the surgery. Outcomes: Twelve months after radiotherapy, the patient's chest CT showed multiple metastases in both lungs. The patient was started on combination chemotherapy of doxorubicin and ifosfamide, and the follow-up is still ongoing. Lessons: Imaging provides a unique advantage to determine the extent of the IDCS, the invasion of adjacent tissues, and the presence or absence of distant metastases.

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Section: Discussionmentioning

confidence: 99%

Retroperitoneal dendritic cell sarcoma

Wang¹,

Lei

Wan³

et al. 2021

Medicine

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“…In contrast to other types of myeloid-derived DCs (such as Langerhans cells, interdigitating DCs and dermal/interstitial DCs), FDCs seem to stem from bone marrow stromal cells, with myofibroblasts as a characteristic ( 35 , 42 ). FDCs are located in primary and secondary follicles, trapping and presenting antigens to B cells, and storing immune complexes for long periods of time on the cell surface ( 58 , 59 ). The cause of FDCT remains unknown; potential risk factors may be Epstein Barr Virus (EBV) infection or Castleman disease ( 2 , 26 ), which may be found concurrently with FDCS or may precede the latter by several years ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…IHC and ISH are essential for the diagnose of FDCS. No single marker is able to identify all DC subsets; as described in the WHO classification ( 58 , 60 ), important markers include D2-40, CD23, CD21 and CD35 ( 3 ). In the two cases of the present study, the tumor cells were both positive for CD21.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

2021

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Follicular dendritic cell sarcoma (FDCS) is an extremely rare tumor, which mainly originates from FDCs in the lymph nodes. Sometimes FDCS can arise from outside the lymph nodes due to the existence of acquired lymphoid tissue, which becomes the histological basis of the tumor. The diagnosis of FDCS, particularly extranodal FDCS, presents a challenge for pathologists and hematopathologists. The present study presents two cases of extranodal FDCS based on clinical features and histomorphology. Soft tissue of the chest wall was involved in case 1 and right tonsil tissue in case 2. Case 1 underwent surgery, and was in good health post-operatively. During the 5-month post-operative follow-up period, the patient was healthy in all respects. Case 2 received surgery combined with radiotherapy, and the follow-up data reported that the patient remained alive, without signs of recurrence or metastasis during the 4-month post-operative follow-up period. Additionally, a total of 102 cases of extranodal FDCS were retrieved from the literature, which were extracted and reviewed carefully. The rates of recurrence, metastasis and mortality were 14.63 (12/82), 17.07 (14/82) and 8.29% (15/82), respectively. The overall survival rates of the 102 cases, showing 2-year total survival rates, were 70%, the same with that of 5-year total survival rates. The 2-year tumor-free total survival rates were 68%, and the 5-year equivalents were 32%. Female patients had a poorer prognosis than male patients (P<0.05). Kaplan-Meier estimation presented no statistically significant differences between disease-free survival rates or overall survival rates and age, tumor size or treatment (P>0.05).

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“…Overview.-IDCS is a dendritic cell neoplasm that has only been described in case reports and small case series totaling approximately 100 reported cases. [56][57][58][59][60] While lymph node involvement is the most common presentation, involvement of extranodal sites, including the skin, stomach, adrenal gland, and mesentery, has also been documented. 61 Most cases are asymptomatic, although presentation varies with the area of involvement and mass size.…”

Section: Interdigitating Dendritic Cell Sarcomamentioning

confidence: 99%

Nonlymphoid Hematopoietic Diseases Presenting in Bone, Soft Tissue, and Other Extranodal Sites

Cassidy

Rosenberg

Poveda

et al. 2021

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Although rare in everyday practice, the initial presentation of hematopoietic neoplasms other than lymphoma in the musculoskeletal system and other extranodal sites can generate challenging diagnostic problems for surgical pathologists. Objective.— To review the morphologic and immunophenotypic features of various nonlymphoid hematopoietic diseases presenting at extranodal sites, with emphasis on the inherent diagnostic pitfalls and differential diagnoses of these entities to aid surgical pathologists in their accurate recognition. Data Sources.— Cases reviewed herein represent both in-house and consult cases seen at our institution between 2010 and 2021. Conclusions.— Entities that present in this way include myeloid neoplasms and histiocytic/dendritic cell neoplasms. These tumors commonly cause nonspecific symptoms, and their histologic appearance can overlap with a variety of benign neoplasms and reactive processes. This can lead to delay in diagnosis and intervention with potentially lifesaving therapy; thus, accurate and expedient recognition is of paramount importance.

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Interdigitating dendritic cell sarcoma located in the groin: a case report and literature review

Cited by 10 publications

References 35 publications

Retroperitoneal dendritic cell sarcoma

Retroperitoneal dendritic cell sarcoma

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

Nonlymphoid Hematopoietic Diseases Presenting in Bone, Soft Tissue, and Other Extranodal Sites

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