Interdisciplinary Aspects of Primary Hyperparathyroidism: Symptomatology in a Series of 100 Cases

Jodkowska, Anna; Tupikowski, Krzysztof; Szymczak, J; Bohdanowicz-Pawlak, Anna; Bolanowski, Marek; Bednarek-Tupikowska, Grażyna

doi:10.17219/acem/42626

Cited by 12 publications

(8 citation statements)

References 36 publications

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“…Recently, primary HPT means the HPT table on which there are no complaints of skeletal, renal and neuromuscular systems [7][8][9][10] . Despite being asymptomatic during preoperative evaluations, patients often report post-operative retrospective amelioration of unreported preoperative sign and symptom of hyperparathyroidism 29 .…”

Section: Discussionmentioning

confidence: 99%

“…The most frequent cause (% 80-85) for PHPT is parathyroid adenoma [5][6][7][8] . The patients of hyperparathyroidism frequently consult doctors with complaints of bone pain, renal calculus, constipation, fatigue, drinking too much water, need to urinate and broken bones stories 9,10 . Asymptomatic pHPT has a prevalence of between 72.7% and 95%, and it becomes the dominant phenotype of pHPT in modern western societies 11,12 .…”

Section: Introductionmentioning

confidence: 99%

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Should We Look For Blood Parathormone in Patients with Vertigo?

Demirbilek¹,

Evren²

2019

Kafkas J Med Sci

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Aim: Though vertigo is a symptom which is defined by an individual as spinning of themselves or an object, it is generally defined by the patients as the sensation of falling, disequilibrium, dizziness and fainting. The main problem on the patients is the determination of the underlying illness. Most of vertigos have peripheral causes and benign paroxysmal positional vertigo takes the first place. It is followed by peripheral and central causes. Patients usually consult the policlinics of Ear, Nose and Throat, internal medicine, neurology in addition to emergency departments with balance disorders. These patients undergo examinations, screening methods, audiology and balance tests and routine blood tests. Material and Method: In this study in which 397 patients who consulted the hospital with complaints of vertigo between 2011 and 2017 evaluated retrospectively. Results: In our study, first of all peripheral causes and 44.8% of these were benign paroxysmal positional vertigo. Hyperparathyroidism was detected in 4 (1%) of the cases in our patient groups that the only complaint was dizziness and there were no other characteristics in the examinations. Parathyroid adenoma was detected in three of them and hyperplasia was detected in the other. In the ones who had adenoma after parathyroidectomy and in the other case after bisphosphonate treatment, both parathormone levels decreased to normal and vertigo complaints totally disappeared. Conclusion: It is recommended that parathormone values should be taken into account in the blood tests during the process of diagnosis in vertigo patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Should We Look For Blood Parathormone in Patients with Vertigo?

Demirbilek¹,

Evren²

2019

Kafkas J Med Sci

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“…This study also concluded that PHPT is often detected too late, for 35% of cases are diagnosed more than 10 years after the first appearance of a characteristic symptom. This statistic speaks to the importance of viewing pancreatitis, especially in the absence of an obvious etiology, as a potential bellwether of PHPT [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Severe Acute Pancreatitis as an Index Clinical Manifestation of Parathyroid Adenoma

Sunkara¹,

Caughey²,

Rawla³

et al. 2018

Cureus

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Hypercalcemia due to primary or secondary hyperparathyroidism is a rare and obscure cause of acute pancreatitis. Although a rare occurrence to begin with, hyperparathyroidism commonly manifests with symptoms of hypercalcemia. Thus, it would reason that a patient might develop pancreatitis by way of hypercalcemia due to primary or secondary hyperparathyroidism. We present a case of an 88-year-old female with acute pancreatitis and only after an extensive work-up, was it determined that her severe acute pancreatitis resulted from primary hyperparathyroidism caused by a left parathyroid adenoma.

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“…To overcome these pitfalls, in some of these studies the neoplasia that had occurred before the 1HPT diagnosis were excluded (11,13). This, however, could have introduced a further bias, since in 1HPT patients the diagnostic delay may be even of 10 years (25). Finally, in all previous studies a complete characterization of subjects with and without 1HPT regarding their comorbidities and risk factors for cancer was lacking, rendering the finding of an increased cancer risk in 1HPT not clearly demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of cancer have been ascertained by verifying the medical reports. This length of (25). In addition, from all patients we obtained information regarding the occurrence of fragility fractures (at spine, ribs, wrist, hip, and proximal humerus), cardiovascular events (i.e.…”

Section: Design Of the Study And Patientsmentioning

confidence: 99%

Occurrence of malignant neoplasia in patients with primary hyperparathyroidism

Palmieri

Roggero

Cairoli

et al. 2017

European Journal of Internal Medicine

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Background. The association between primary hyperparathyroidism (1HPT) and cancer is debated. The present study was aimed to investigate the occurrence of neoplasia in 1HPT.Methods: All consecutive patients (n=1750) referred to our "Osteoporosis and Metabolic Disease" outpatients clinic for osteoporosis or hypercalcemia were eligible for the study. The exclusion criteria were: the finding of osteoporosis and/or altered calcium-phosphorous metabolism in the context of investigations for malignancy, the presence of diseases known to influence the cancer risk and the heavy smoking habit.Eventually, 1606 patients (1407 females, 199 males) were enrolled. In all patients calcium-phosphorous metabolism, PTH and vitamin D levels were measured and the occurrence of cancer during the 10 years prior the study inclusion was recorded.Results: 163 patients had 1HPT while 1443 had not. Patients with and without 1HPT were comparable for age and gender. In 1HPT patients the occurrence of all, breast, kidney and skin cancer was significantly higher (21.5%, 12.2%, 2.5%, 1.8%, respectively) than in patients without 1HPT (12.4%, 6.9%, 0.3%, 0.3%, p<0.05 for all comparisons). The 1HPT presence was significantly associated with the occurrence of all

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Interdisciplinary Aspects of Primary Hyperparathyroidism: Symptomatology in a Series of 100 Cases

Cited by 12 publications

References 36 publications

Should We Look For Blood Parathormone in Patients with Vertigo?

Should We Look For Blood Parathormone in Patients with Vertigo?

Severe Acute Pancreatitis as an Index Clinical Manifestation of Parathyroid Adenoma

Occurrence of malignant neoplasia in patients with primary hyperparathyroidism

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