Interest of Bone Histomorphometry in Bone Pathophysiology Investigation: Foundation, Present, and Future

Chavassieux, Pascale; Chapurlat, Roland

doi:10.3389/fendo.2022.907914

Cited by 17 publications

(10 citation statements)

References 214 publications

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“…In this study, we only included papers reporting osteoclast indices for OI patients prior to treatment with bisphosphonate or after the drug holiday to minimize the treatment effect on osteoclast physiology. Osteoclast function in clinical studies can be assessed by bone histomorphometry, which requires invasive transiliac biopsy 17 or by examining blood or urine levels of collagen degradation markers indicative of increased bone turnover 80 . Previously, prominent increases in bone resorption markers were reported in OI children 29,35,37 , while osteoclast indices in bone histomorphometry were variably affected 11,25 .…”

Section: Discussionmentioning

confidence: 99%

“…The following data items relevant to study characteristics were extracted (Supplemental materials): i) for all studies: authors; publication year and country; ii) for studies involving human subjects: publication type (case report or clinical study), age; sex; OI type (when given); OI severity (when given); sample size; control groups (when given); type of diagnosis (clinical or genetic or family history); treatments (when given) and study design; iii) for animal studies using mouse models of OI: strain; genotype; age; sex; OI severity (when given); sample size; control groups and treatment (when given). For the osteoclast related outcomes, we extracted the data for OI and control group for urine or serum levels of collagen degradation markers, C-terminal telopeptide of type 1 collagen (CTX), N-terminal telopeptide of type 1 collagen (NTX) or urinary deoxypyridinoline (DPD) 16 , and osteoclast parameters from bone histomorphometric analysis (osteoclast number, osteoclast surface, resorptive surface and eroded surface 17 ). Data items included bone type and bone region being measured; type of bone turnover marker; measurement technique; mean or median (as applicable) and standard errors, standard deviations, and/or interquartile ranges of reported outcomes.…”

Section: Data Extraction Data Items and Conversionmentioning

confidence: 99%

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Osteoclast indices in osteogenesis imperfecta: systematic review and meta-analysis

Aksornthong,

Patel,

Komarova

2024

Preprint

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Background: Osteogenesis imperfecta (OI) is a rare bone fragility disorder caused by mutations in genes that encode collagen type I or affect its processing. Alterations in bone resorbing osteoclasts were suggested to contribute to OI pathophysiology. We aimed to systematically identify studies reporting measures of osteoclast formation and function in patients and mouse models of OI, to quantify OI-induced changes. Results: The systematic search of Medline, OVID and Web of Science identified 798 unique studies. After screening, we included for meta-analysis 23 studies reporting osteoclast parameters in 310 OI patients of 9 different types and 16 studies reporting osteoclast parameters in 406 animals of 11 different OI mouse models. The standardized mean difference was used as the effect size, random effects meta-analysis was performed using R-studio. In OI patients, collagen degradation markers were significantly higher in patients with OI compared to age-matched control with the effect size of 1.23 [Confidence interval (CI): 0.36, 2.10]. Collagen degradation markers were the most elevated in the 3 to 7-year-old age group, and in patients with more severe forms of OI. Bone histomorphometry demonstrated the trends for higher osteoclast numbers, 1.16 [CI: -0.22, 2.55], and osteoclast surface, 0.43 [CI: -0.63; 1.49], and significantly higher eroded surface, 3.24 [CI: 0.51, 5.96] compared to the aged-match control. In OI mice, meta-analysis demonstrated significant increases in collagen degradation markers, 1.59 [CI: 1.07, 2.11]; in osteoclast numbers, 0.94 [CI: 0.50, 1.39], osteoclast surface, 0.73 [CI:0.22, 1.23], and eroded surface 1.31[CI: 0.54, 2.08]. The largest differences were in OI mice with the mutations in Col1a1 and Col1a2 genes. There were no differences between males and females in clinical or animal studies. Conclusions: Quantitative estimates of changes in osteoclast indices and their variance for patients with OI are important for planning future studies. We confirmed that similar changes are observed in mice with OI, supporting their translational utility.

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Section: Discussionmentioning

confidence: 99%

Section: Data Extraction Data Items and Conversionmentioning

confidence: 99%

Osteoclast indices in osteogenesis imperfecta: systematic review and meta-analysis

Aksornthong,

Patel,

Komarova

2024

Preprint

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“…Bone histomorphometry remains the only method to analyze bone at the tissue and cell levels despite the development of noninvasive approaches [ 41 , 42 ]. Under histologic observations, it has been confirmed that ADB demonstrates biological compatibility and does not cause any significant inflammatory reaction.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Autogenous Dentin Biomaterial on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial

Hussain,

Al-Quisi,

Abdulkareem

2023

BioMed Research International

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Background. After tooth extraction, alveolar bone resorption is inevitable. This clinical phenomenon challenges dental surgeons aiming to restore esthetic and function. Alveolar ridge preservation can be applied to minimize dimensional changes with a new socket grafting material, an autogenous dentin graft, produced by mechanically and chemically processing natural teeth. This study assessed the safety and efficacy of using autogenous dentin biomaterial in alveolar ridge preservation. Materials and Methods. Patients with nonrestorable maxillary anterior teeth bounded by natural sound teeth were included in this study. After a detailed clinical and tomographic examination, eligible participants were randomly allocated into two groups. The control group had spontaneous healing of extraction sockets. The study group had their extraction sockets filled with autogenous dentin biomaterial after processing their extracted retained roots with the KometaBio device. Standardized cone beam computed tomography (CBCT) scans were repeated four months later. A full-thickness mucoperiosteal flap reflection was achieved under local anesthesia to get core biopsies for histomorphometric analysis, and dental implants were placed at the same session. Results. A total of 32 eligible patients were included in this study (n=16 in each group). Both groups had significantly higher facial soft tissue thickness after four months than baseline (p<0.05). However, the study group showed statistically significant lesser dimensional changes than the control group according to the standardized CBCT scans. Furthermore, core biopsies confirmed an excellent remodeling of the autogenous dentin biomaterial in the study group. In comparison, only new thin bone trabeculae-filled sockets were in the control group. Conclusion. Autogenous dentin graft can be safely and successfully used for alveolar ridge preservation. Optimal graft remodeling histologically, better ridge dimensional stability, and uneventful wound healing support its clinical application. This trial is registered with TCTR20220615002.

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“…A detailed review of the use of bone morphometry for clinical medicine and research can be found here. 23 …”

Section: History and Evolution Of Bone Morphometrymentioning

confidence: 99%

Celebrating 50-years: the history and future of the International Society of Bone Morphometry

Scheller,

McDonald,

Andersen

et al. 2024

JBMR Plus

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The International Society of Bone Morphometry (ISBM) is dedicated to advancing research, education, and clinical practice for osteoporosis and other bone disorders by developing and improving tools for the quantitative imaging and analysis of bone. Its initial core mission was to promote the proper use of morphometric techniques in bone research and to educate and train clinicians and basic scientists in bone morphometry. This article chronicles the evolution of the ISBM and the history and development of bone morphometric techniques for the past 50-years, starting with workshops on bone morphometry in 1973, to the formal incorporation of the ISBM in 1996, to today. We also provide a framework and vision for the coming decades. This effort was led by ISBM presidents Dr Erica L. Scheller (2022-2024) and Dr Thomas J. Wronski (2009-2012) in collaboration with all other living ISBM presidents. Though the underlying techniques and questions have changed over time, the need for standardization of established tools and discovery of novel approaches for bone morphometry remains a constant. The ISBM fulfills this need by providing a forum for the exchange of ideas, with a philosophy that encourages the open discussion of pitfalls and challenges among clinicians, scientists, and industry partners. This facilitates the rapid development and adaptation of tools to meet emerging demands within the field of bone health at a high level.

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Interest of Bone Histomorphometry in Bone Pathophysiology Investigation: Foundation, Present, and Future

Cited by 17 publications

References 214 publications

Osteoclast indices in osteogenesis imperfecta: systematic review and meta-analysis

Osteoclast indices in osteogenesis imperfecta: systematic review and meta-analysis

Efficacy of Autogenous Dentin Biomaterial on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial

Celebrating 50-years: the history and future of the International Society of Bone Morphometry

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