Interest of Chromogranin A for diagnosis and follow‐up of endocrine tumours

Nehar, Diane; Lombard‐Bohas, Catherine; Olivieri, Silvana; Bruno, Claudio; Ja, Chayvialle; Mc, Penes; Sassolas, G.; Borson‐Chazot, Françoise

doi:10.1111/j.1365-2265.2004.02030.x

Cited by 149 publications

(128 citation statements)

References 38 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…A különböző endokrin szö-vetekben proteolitikus módosításokat követően alakul át extracellulárisan működő biológiailag aktív peptidformákká. A CgA-ból kialakuló fehérjék, mint a pancreastatin, a vasostatin, a WE-14 és további formák jelentős és specifi kus biológiai hatással rendelkeznek (1. táblázat) [26,27,28,29,30,34,35,45,47,48,49,50,51,52].…”

Section: Következtetésekunclassified

The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

et al. 2015

View full text Add to dashboard Cite

A kromogranin-A a granincsaládba tartozó fehérje, amelyet neuroendokrin sejtek termelnek és ezek szekréciós granulumaiból származik. A kromogranin-A-ból számos, mind ez idáig kevésbé tisztázott funkciójú fehérje képződik. Jelenleg a kromogranin-A vérben mérhető szintjének meghatározását elsősorban neuroendokrin daganatok laboratóriumi diagnosztikájában használják. A legfrissebb kutatások alapján azonban úgy tűnik, a kromogranin-A-ból szár-mazó WE-14 nevű fehérjének szerepe lehet az 1-es típusú cukorbetegség kialakulásában is. A WE-14 fehérje autoantigénként viselkedik a β-sejtek elpusztításában részt vevő T-sejtek számára. Ezt a mechanizmust eddig specifi kusan a nem obes diabetogén egerekben fi gyelték meg. Újabb eredmények alapján a WE-14 a diabeteses egerek mellett az újonnan diagnosztizált 1-es típusú cukorbetegeknél is az autoreaktív sejtek célpontjaként szolgál, amely reakció szö-veti transzglutamináz enzimmel fokozható. A szerzők jelen összefoglalójukban áttekintik a kromogranin-A bioszintézisét, biokémiai jellegzetességeit, szervezetbeli funkcióit, valamint ismertetik a cukorbetegség patomechanizmusá-ban betöltött szerepére vonatkozó jelen ismereteket. Orv. Hetil., 2015, 156(5), 163-170. Kulcsszavak: kromogranin-A, diabetes mellitus, tumormarker, WE-14The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus Chromogranin-A is a member of the granine protein family. It is produced in neuroendocrine cells via secretory granules. Many cleavage proteins are formed from chromogranin-A, from which some have well known biological activity, while the function of others is not yet fully known. Serum chromogranin-A levels are used in neuroendocrine tumour diagnostics. Recent studies showed that one of its cleavage protein, WE-14 may also play a role in the development of type 1 diabetes. WE-14 may function as an autoantigen for T-cells involved in the destruction of β-cells. This mechanism was previously observed only in non-obese diabetic mice. Novel results show that WE-14 also serves as a target for autoreactive cells in newly diagnosed type 1 diabetic patients as well, which reaction can be increased with transglutaminase. In this paper the authors summarize the recent knowledge about chromogranin-A and its potential role in the pathomechanism of type 1 diabetes mellitus.Keywords: chromogranin-A, diabetes mellitus, tumour marker, Z., Nagy, P., Patócs, A., Somogyi, A. [The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus]. Orv. Hetil., 2015, 156(5), 163-170.

show abstract

Section: Következtetésekunclassified

The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Recent studies confirmed that the measurement of CgA levels in blood can also be used to diagnose and to monitor neuroendocrine tumours during treatment [6,10,14,[16][17][18].…”

Section: Introductionmentioning

confidence: 92%

“…In every case of diagnosed NET determination of CgA concentration has a significant impact on the prognosis and the choice of treatment and clinical outcome. Prognosis for the patients with NET secreting CgA is better, having a longer survival time and a prolonged time to progression [5,10,18,22,24,25].…”

Section: Introductionmentioning

confidence: 99%

“…This physiological protein of MW 48 kDa [6][7][8] is produced and stored together with biogenic amines and other peptide hormones in the secretory granules called large dense-core vesicles of the neuroendocrine cells [2,[4][5][6]9,10], which are widespread in the whole organism and form the diffused endocrine system (DES) [11][12][13]. The neuroendocine cells can be found in: adrenal medulla, sympathetic nerves endings, cerebral cortex, pituitary gland, gastrointestinal tract, thyroid, parathyroid glands, pancreatic islets and lungs [2,4,8,10]. The synthesis and secretion of CgA may be intensified in the neuroendocrine tumour (NET) cells [4,9,14,15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Significance of plasma chromogranin A determination in neuroendocrine tumour (NET) diagnosis.

Donica

Malecha-Jędraszek²,

Strosławska³

et al. 2011

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

“…Patients treated with long-term histamine type 2 receptor antagonists or proton pump inhibitors also have raised circulating CgA. 86,87 Because of all these, gastric hypochlorhydric and achlorhydric states are common; care must be taken in the interpretation of CgA results. A circulating CgA concentration of more than twice the reference range is usually indicative of NET, whereas concentrations lower than this are inconclusive.…”

Section: Chromogranin Bmentioning

confidence: 99%

Circulating markers for endocrine tumours of the gastroenteropancreatic tract

Ardill

2008

Ann Clin Biochem

View full text Add to dashboard Cite

The diffuse endocrine system (DES) includes a wide range of secretory cells that may be the source of tumours. Gastroenteropancreatic endocrine (GEP) tumours arising within the DES secrete a variety of peptides and amines that are found in the circulation and are responsible for the syndromes associated with these tumours. In this review, the most common tumours of the GEP tract are outlined and the circulating products of these tumours identified. Where differential diagnosis is difficult these points are addressed. The peptides most commonly secreted by GEP neuroendocrine tumours are identified and described and their biological activities are discussed. Current methods available for measurement of these peptides are described. Attention is drawn towards molecular specificity where appropriate, as many pancreatic and gut peptides fall within families which show considerable homology, such as the tachykinin family or the glucagon family. Other peptides such as gastrin circulate in multiple molecular forms. This homology and diversity may cause difficulty in the interpretation of peptide measurements in the clinical situation if assays are not specific.

show abstract

Interest of Chromogranin A for diagnosis and follow‐up of endocrine tumours

Cited by 149 publications

References 38 publications

The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

Significance of plasma chromogranin A determination in neuroendocrine tumour (NET) diagnosis.

Circulating markers for endocrine tumours of the gastroenteropancreatic tract

Contact Info

Product

Resources

About