Interest of cystatin C in screening diabetic patients for early impairment of renal function

Perlemoine, Caroline; Beauvieux, Marie-Christine; Rigalleau, Vincent; Baillet, Laurence; Barthes, N.; Derache, P.; Gin, H.

doi:10.1016/s0026-0495(03)00193-8

Cited by 40 publications

(43 citation statements)

References 25 publications

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“…Two further studies, which did notemploy a gold standard method for GFR, confirmed that cystatin C better differentiates GFR values among type 1 [18] and type 2 [16,18] diabetic patients. Two studies [13,19], on the other hand, showed that cystatinC is not more sensitive than creatinine for detecting early renal failure. Such discrepancies may be attributable at least in part tointraassay variations for creatinine and cystatin C measurements related to differences in assay techniques.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have used direct measures of GFR as the gold standard to compare cystatin C with creatinine and creatinine-derived estimates of GFR [11]. Several studies have also been conducted on diabetic patients [12][13][14][15][16][17][18][19][20][21] in whom cystatin C seems to out-perform creatinine-based estimations [12,[14][15][16][17][18]20,21]. The clinical utility of cystatin still remains uncertain [22].…”

Section: Introductionmentioning

confidence: 99%

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Use of Serum Cystatin C in Assessment of Early Deterioration of Renal Function in Type 2 Diabetic Industrial Workers in Port Harcourt, Nigeria

Godwill¹,

Ntuen²

2013

IOSR-JDMS

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Early detection of deterioration or impairment in renal function is critical in management of diabetic patients. Serum cystatin C may be the most sensitive indicator of glomerular filtration rate (GFR) in a clinical environment.We compared cystatin C with creatinine, the Cockcroft-Gault (C-G) In our study population, cystatin C (P<0.001) was better correlated with glomerular filtration rate (GFR) (r=0.922) than were creatinine (r=743), Cockcroft-Gault (C-G)formular (r=0.755) and Modification of Diet in Renal Disease (MDRD) equation (r=0.818). Mean cystatin C concentrations showed step wise statistically significant increases as GFR reduces, allowing very early identification of reduction in renal function. At 90ml/min/1.73m2 and 75ml/min/1.73m 2 cut-points, diagnostic efficiencies of cystatin C (90% and 93%) were better than those of the other variables (80%-84% and 86%-89%, respectively; P = 0.01).All data supported the value of serum cystatin C compared with conventional estimates based on serum creatinine measurement for detecting very early reduction of renal function. Use of cystatin C to measure renal function will make for early detection, prevention, and treatment of diabetic nephropathy in type 2 diabetics.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of Serum Cystatin C in Assessment of Early Deterioration of Renal Function in Type 2 Diabetic Industrial Workers in Port Harcourt, Nigeria

Godwill¹,

Ntuen²

2013

IOSR-JDMS

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“…The only exception is the study by Oddoze et al (95) in which the performance of creatinine can be considered to be abnormally good. Perlemoine et al did not find CysC to offer any advantage in detecting GFR -80 mL/min/1.73 m 2 , except in the sub-group of patients with a creatinine of less than 1 mg/dL (88 mmol/L) (96). Of these different studies, the study by Pucci et al which examined 288 diabetic patients (both types) with GFR measurement by plasma iohexol clearance and a wide range of GFR is undoubtedly one of the most important studies (162).…”

Section: Diabetic Patientsmentioning

confidence: 95%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

164

145

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Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86.

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“…Caroline pedemoine et al evaluated in their study [53] that cystatin C as a marker of renal impairment in a large population of diabetic patients. Cystatin C was well correlated with GFR, and its diagnostic accuracy was comparable to that of creatinine.…”

Section: Cystatin C In Other Patient Groupsmentioning

confidence: 99%

“…Cystatin C was well correlated with GFR, and its diagnostic accuracy was comparable to that of creatinine. The high sensitivity of cystatin C and its diagnostic accuracy at low creatinine levels makes it a good prediction of later renal impairment in diabetic patients, especially as the value of micro albuminuna in there patients has been questioned by recent work [53].…”

Section: Cystatin C In Other Patient Groupsmentioning

confidence: 99%

Cystatin C—A novel marker of glomerular filtration rate: A review

Sarkar¹,

Rajeshwari

Shivaprakash³

2005

Indian J Clin Biochem

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Glomerular filtration rate is routinely assessed by measuring the serum markers such as urea nitrogen and serum creatinine. Although these markers are widely used to assess renal function but they do not perform optimally in certain clinical settings. There is thus a practical need for an easily automated alternative to plasma creatinine, which would be more specific, sensitive and reliable from the analytical and clinical view point. Compared with the above endogenous markers, and time consuming laborious tests, Cystatin C facilitates the recognition of abnormal renal function in children, as its reference range is constant beyond the 1 ~ year of life. This review mainly focuses on the diagnostic performance of Cystatin C against other renal markers in the pediatric population and in specific subpopulations of patients.

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Interest of cystatin C in screening diabetic patients for early impairment of renal function

Cited by 40 publications

References 25 publications

Use of Serum Cystatin C in Assessment of Early Deterioration of Renal Function in Type 2 Diabetic Industrial Workers in Port Harcourt, Nigeria

Use of Serum Cystatin C in Assessment of Early Deterioration of Renal Function in Type 2 Diabetic Industrial Workers in Port Harcourt, Nigeria

Cystatin C: current position and future prospects

Cystatin C—A novel marker of glomerular filtration rate: A review

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