Interest of fine-needle aspiration cytology in thyroid nodule

Sellami, M.; Tababi, S.; Mamy, J.; Zainine, R.; Charfi, A.; Beltaief, N.; Sahtout, S.; Besbes, G.

doi:10.1016/j.anorl.2011.01.003

Cited by 11 publications

(8 citation statements)

References 29 publications

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“…Salivary gland tumors, because of their diversity, till date continue to hold the interest of the surgeons and the pathologists. Although fine needle aspiration cytology (FNAC) is now part of routine clinical practice for the evaluation of thyroid tumors[ 1 ] and cervical lymph nodes, no consensus has been reached concerning the role of this procedure in the management of salivary glands lesions, as some authors consider that it has a low sensitivity for diagnosis of malignant salivary tumors. [ 2 3 ]…”

Section: Introductionmentioning

confidence: 99%

Role of fine-needle aspiration cytology in the diagnosis of major salivary gland tumors: A study with histological and clinical correlation

Shetty

Geethamani

2016

J Oral Maxillofac Pathol

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Introduction:Neoplastic lesions of salivary glands present an interesting subject because of their histologic diversification. Complex features exhibited by them have aroused considerable speculations concerning their histogenesis and continues to hold the interest of clinicians and pathologists. Major salivary glands are superficial and have easy accessibility for fine-needle aspiration cytology (FNAC). These glands are generally not subjected to incisional or core needle biopsy, because of the possible risks of fistula formation and tumor seedling. FNAC diagnosis of major salivary gland neoplasms aids in proper planning of required surgery and avoidance of the same in cases of non-neoplastic lesions.Materials and Methods:Cytological features of major salivary gland tumors diagnosed on FNAC were studied over a period of one and a half years. Cytological and architectural patterns in smears were compared with histopathological features in cases where the specimens were available with a note on the age, sex and presenting complaints. Statistical Analysis: Analysis of variance (ANOVA) was used to find the significance of study parameters. Chi-square/Fisher Exact was used to find the significance of study parameters on categorical scale between two or more groups. P value of <0.05 was considered to be significant.Results:A total of 114 salivary gland FNACs were done, 75 patients were clinically suspected to be neoplasms. The peak incidence was in the third to fourth decade of life with a female preponderance. Parotid was the most commonly affected gland (80%) with pleomorphic adenoma and mucoepidermoid carcinoma (10.7%) being the most common benign and malignant tumors respectively. The diagnostic accuracy of FNAC was 97.6%. Warthins tumor was misdiagnosed and was associated with a strong smoking history.Conclusion:Salivary gland neoplasms constitute a small but significant percentage of head and neck tumors. FNAC is inexpensive, quick, and aids in the preoperative diagnosis and planning of surgery.

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Section: Introductionmentioning

confidence: 99%

Role of fine-needle aspiration cytology in the diagnosis of major salivary gland tumors: A study with histological and clinical correlation

Shetty

Geethamani

2016

J Oral Maxillofac Pathol

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“…malignancy rate in this category was 29.2% (6 cases were PTC and one case of FTC), the remaining nodules proved to be benign (6 lymphocytic thyroiditis, 8 follicular adenomas, 2 Hürthle cell adenomas, and one case of subacute thyroiditis). Consequently, these results made a low malignancy rate, this rate was lower than other studies [13][14][15][16], but a lower malignancy rate was seen in some series [20].…”

Section: Bethesda Category N (%) This Seriesmentioning

confidence: 51%

“…Finally, FNA accuracy parameters differ among different studies according to the categories included as a positive for malignancy, some studies [13][14][15]20] included indeterminate cytology, while our study and others [24] did not. False positive results lowered specificity in our study to 79.35% compared with other studies (68.4%-97.6%), results are summarized in table 4, with a sensitivity of 85% compared with (94.2%-100%), and total accuracy of 80.36% while other studies reported the accuracy of (85.14%-97%).…”

Section: International Journal Of Endocrinology and Metabolic Disordersmentioning

confidence: 60%

Comparison between Fine Needle Aspiration Cytology of Thyroid Nodules and Histology after Surgical Excision

Alali¹,

Khalil²,

Kabalan³

2019

Int J Endocrinol Metab Disord

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Background: Thyroid nodules are an extremely common disorder. Fine Needle Aspiration (FNA) is the gold standard procedure for thyroid nodules diagnosis and management; it helps clinicians to make a proper therapeutic decision and minimizes the need for unnecessary surgery.Objective: To assess thyroid FNA sensitivity, specificity, accuracy, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) in Al-Assad University Hospital using the Bethesda system for reporting thyroid cytology. Methods: We prospectively followed thyroid FNAs, then the histological results were followed after performing surgery. FNA was performed by endocrinologists in al-Assad and al-Mouwassat university hospitals, and the cytological study for all samples was performed in pathology department at al-Assad university hospital. All available data were analyzed with SPSS version 23 statistical program.

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“…It is increasingly being introduced into everyday clinical practice also in our region (Mures County, Romania). Its use is well established in the management of thyroid nodules [2] – [4] , and it gains more and more popularity also in other fields of medicine such as the evaluation of breast lesions, head and neck masses, and in general superficial and deep lesions [5] – [11] . Diagnosis is based on the interpretation of cytological material aspired with a small diameter needle.…”

Section: Introductionmentioning

confidence: 99%

Making Mock-FNA Smears from Fresh Surgical Pathology Specimens to Improve Smear Preparation Technique and to Create Cytohistological Correlation Series

et al. 2014

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BackgroundFine needle aspiration (FNA) cytology is a well-established diagnostic method based on the microscopic interpretation of often scant cytological material; therefore, experience, good technique and smear quality are equally important in obtaining satisfactory results.Aims of StudyWe studied the use of fresh surgical pathology specimens for making so-called mock-FNA smears with the potential of cytohistological correlation. Additionally, we studied how this process aids the improvement of preparation technique and smear quality.MethodsCytological aspirates from 32 fresh biopsy specimens from various sites: lung (20), lymph nodes (6), and breast (6) were obtained, all with a clinical diagnosis of tumor. Aspiration was performed from grossly palpable tumors. 25G needle and Cameco-type syringe holder was used with minimal or no suction.ResultsUnfixed surgical specimens provided sufficient cytological material that resulted in good quality smears. After standard processing of specimens into microscopic sections from paraffin embedded tissues, cytohistological case-series were created. No significant alteration was reported in tissue architecture on hematoxylin-eosin stained sections after the aspiration procedure. A gradual, but steady improvement was observed in smear quality just after a few preparations.Discussions and ConclusionsOur study proved that surgical specimens may be used as a source of cytological material to create cytohistological correlation studies and also to improve FNA cytology skills. The use of very fine gauge needle (25G, 0,6 mm diameter) during the sampling process does not alter tissue architecture therefore the final histopathological diagnosis is not compromised. We conclude that by using fresh surgical specimens useful cytohistological collections can be created both as a teaching resource and as improving experience.

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Interest of fine-needle aspiration cytology in thyroid nodule

Abstract: The main pitfall of FNAC in thyroid pathology is the "suspect" category, for which positive diagnosis is founded on histological criteria alone. The second limitation identified in this study was the high number of "unrepresentative" aspirates. However, the technique remains useful.

Cited by 11 publications

References 29 publications

Role of fine-needle aspiration cytology in the diagnosis of major salivary gland tumors: A study with histological and clinical correlation

Role of fine-needle aspiration cytology in the diagnosis of major salivary gland tumors: A study with histological and clinical correlation

Comparison between Fine Needle Aspiration Cytology of Thyroid Nodules and Histology after Surgical Excision

Making Mock-FNA Smears from Fresh Surgical Pathology Specimens to Improve Smear Preparation Technique and to Create Cytohistological Correlation Series

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