Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling

Viana, Marylène; Désiré, Amélie; Chevalier, Émilie; Champion, Éric; Chotard-Ghodsnia, Roxana; Chulia, Dominique

doi:10.4028/www.scientific.net/kem.396-398.535

Cited by 11 publications

(7 citation statements)

References 6 publications

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“…CaP bioceramics are usually fabricated either by employing a lubricant and a liquid binder with the ceramic powders for shaping and subsequent firing or by cementation. Various processing routes are attempted to fabricate CaP compounds, which include uniaxial compaction [ 66 , 67 ], cold/hot isostatic pressing [ 68 , 69 , 70 , 71 ], granulation [ 72 ], loose packing [ 73 ], slip casting [ 74 , 75 , 76 ], gel casting [ 77 , 78 , 79 ], pressure mold forming [ 80 ], injection molding [ 81 ], polymer replication [ 82 , 83 , 84 ], extrusion [ 85 , 86 ], slurry dipping and spraying [ 87 ]. Furthermore, the formation of ceramic sheets by tape casting is also widely employed [ 88 , 89 ].…”

Section: Discussion On Dense Hydroxyapatitesmentioning

confidence: 99%

Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review

Prakasam

Ločs

Šalma-Ancāne

et al. 2015

JFB

237

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In the last five decades, there have been vast advances in the field of biomaterials, including ceramics, glasses, glass-ceramics and metal alloys. Dense and porous ceramics have been widely used for various biomedical applications. Current applications of bioceramics include bone grafts, spinal fusion, bone repairs, bone fillers, maxillofacial reconstruction, etc. Amongst the various calcium phosphate compositions, hydroxyapatite, which has a composition similar to human bone, has attracted wide interest. Much emphasis is given to tissue engineering, both in porous and dense ceramic forms. The current review focusses on the various applications of dense hydroxyapatite and other dense biomaterials on the aspects of transparency and the mechanical and electrical behavior. Prospective future applications, established along the aforesaid applications of hydroxyapatite, appear to be promising regarding bone bonding, advanced medical treatment methods, improvement of the mechanical strength of artificial bone grafts and better in vitro/in vivo methodologies to afford more particular outcomes.

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Section: Discussion On Dense Hydroxyapatitesmentioning

confidence: 99%

Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review

Prakasam

Ločs

Šalma-Ancāne

et al. 2015

JFB

237

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“…Since calcium orthophosphates are either thermally unstable (MCPM, MCPA, DCPA, DCPD, OCP, ACP, CDHA) or have a melting point at temperatures exceeding ~1400 °C with a partial decomposition (α-TCP, β-TCP, HA, FA, TTCP), only the first and the second consolidation approaches are used to prepare bulk bioceramics and scaffolds. The methods include uniaxial compaction [198,199,200], isostatic pressing (cold or hot) [108,201,202,203,204,205,206,207], granulation [208,209,210,211,212,213], loose packing [214], slip casting [93,215,216,217,218,219,220], gel casting [188,189,221,222,223,224,225], pressure mold forming [226], injection molding [227,228,229], polymer replication [230,231,232,233,234,235,236,237], extrusion [238,239,240,241,242], slurry dipping and spraying [243]. In addition, to form ceramic sheets from slurries, tape casting [105,223,244,245,246], doctor blade [247] and colander me...…”

Section: Bioceramics Of Calcium Orthophosphatesmentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

232

153

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Various types of grafts have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In principle, bioceramics can be prepared from diverse materials but this review is limited to calcium orthophosphate-based formulations only, which possess the specific advantages due to the chemical similarity to mammalian bones and teeth. During the past 40 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the calcium orthophosphate-based implants remain biologically stable once incorporated into the skeletal structure or whether they were resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed and such formulations became an integrated part of the tissue engineering approach. Now calcium orthophosphate scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous and harbor different biomolecules and/or cells. Therefore, current biomedical applications of calcium orthophosphate bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery. Perspective future applications comprise drug delivery and tissue engineering purposes because calcium orthophosphates appear to be promising carriers of growth factors, bioactive peptides and various types of cells.

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“…Since calcium orthophosphates are either thermally unstable (MCPM, MCPA, DCPA, DCPD, OCP, ACP, CDHA) or have a melting point at temperatures exceeding ~ 1400 °C with a partial decomposition (α-TCP, β-TCP, HA, FA, TTCP), only the first and the second consolidation approaches are used to prepare bulk bioceramics and scaffolds. The methods include uniaxial compaction [198,199], isostatic pressing (cold or hot) [200][201][202][203][204][205][206], granulation [207,208], loose packing [209], slip casting [210][211][212][213], gel casting [188,189,[214][215][216][217][218][219], pressure mold forming [220], injection molding [221], polymer replication [222][223][224][225], extrusion [226][227][228], slurry dipping and spraying [229], as well as to form ceramic sheets from slurries tape casting [124,216,230,231] doctor blade [232] and colander methods might be employed [194][195][196][197]…”

Section: Forming and Shapingmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling

Cited by 11 publications

References 6 publications

Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review

Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review

Calcium Orthophosphate-Based Bioceramics

Medical Application of Calcium Orthophosphate Bioceramics

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