Interest of Routine Measurement of Serum Calcitonin: Study in a Large Series of Thyroidectomized Patients

Niccoli, Patricia; Wion-Barbot, N.; Caron, Philippe; Henry, J. F.; Micco, C. De; Andre, Jean-Pierre Saint; Bigorgne, J. C.; Modigliani, E; Conte-Devolx, B.

doi:10.1210/jcem.82.2.3737

Cited by 193 publications

(117 citation statements)

References 23 publications

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“…Routine measurement of serum thyroglobulin for initial evaluation of thyroid nodules is not recommended-Recommendation F Serum calcitonin measurement. The utility of serum calcitonin has been evaluated in a series of prospective, nonrandomized studies (24)(25)(26). The data suggest that the use of routine serum calcitonin for screening may detect C-cell hyperplasia and medullary thyroid cancer at an earlier stage FIG.…”

Section: Other Laboratory Testingmentioning

confidence: 99%

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

Cooper

Doherty

Haugen

et al. 2006

Thyroid

1,922

938

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Section: Other Laboratory Testingmentioning

confidence: 99%

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

Cooper

Doherty

Haugen

et al. 2006

Thyroid

1,922

938

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“…However, serum calcitonin measurement is warranted when there is family history of medullary thyroid cancer, multiple endocrine neoplasia type 2 (MEN 2) or pheochromocytoma. Levels above 100 pg/mL are highly suggestive of medullary carcinoma (14,15).…”

Section: Laboratory Evaluationmentioning

confidence: 99%

Latin American Thyroid Society recommendations for the management of thyroid nodules

Camargo

Corigliano

Friguglietti

et al. 2009

Arq Bras Endocrinol Metab

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Several guidelines on diagnosis and treatment of thyroid nodules and cancer have recently been published. However, recommended practices are not always appropriate to different settings or countries. The aim of this consensus was to develop Clinical Guidelines for evaluation and management of patients with thyroid nodules applicable to Latin American countries. The panel was composed by 13 members of the Latin American Thyroid Society involved with research and management of thyroid nodules and cancer from different medical centers in Latin America. The consensus was produced based on the expert opinion of the panel with use of principles of evidence-based medicine. Following a group meeting, a first draft based on the expert opinion of the panel was elaborated and later circulated among panel members for further revision. After revision, this document was submitted to all LATS members for commentaries and considerations and finally revised and refined by the authors. The final recommendations represent state of the art on management of thyroid nodules applied to all Latin American countries. Arq Bras Endocrinol Metab. 2009;53(9):1167-75 Keywords Thyroid nodule; thyroid ultrasonography; thyroid aspiration biopsy; radioactive iodine therapy resumo Vários consensos têm sido publicados acerca do diagnóstico e do tratamento de nódulos e cân-cer da tireoide. Entretanto, as recentes recomendações nem sempre são apropriadas para diferentes regiões ou países. O objetivo deste trabalho foi oferecer uma série de recomendações para a avaliação e conduta de pacientes portadores de nódulos tireoideos aplicáveis a todos os países da América Latina. O trabalho foi realizado por um comitê composto por 13 membros da Sociedade Latino-Americana de Tireoide envolvidos com pesquisa e manejo de pacientes portadores de nódulos e carcinoma diferenciado da tireoide, de diferentes centros médicos da América Latina. As recomendações foram estabelecidas, após consenso, utilizando as opiniões especializadas de cada membro e os princípios da medicina baseada em evidência. Após a primeira reunião do grupo, um primeiro documento foi elaborado e encaminhado a todos os membros para revisão. Posteriormente, o documento foi enviado aos membros da Sociedade Latino-Americana de Tireoide para avaliação, sugestões e comentários. A versão final, elaborada após refinada revisão de todos os autores, representa o estado da arte no diagnóstico e na conduta de nódulos tireoideos, aplicáveis a todos os países da América Latina.

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“…It occurs in 5-10% of thyroid tumors (1) and has a prevalence of between 0.3 and 1.37% in nodular thyroid disease (2)(3)(4)(5)(6)(7)(8)(9). Calcitonin (C T ) is a marker for both initial diagnosis and monitoring of patients with residual or recurrent MTC (10,11).…”

Section: Introductionmentioning

confidence: 99%

Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking

d’Herbomez

Caron²,

Bauters³

et al. 2007

European Journal of Endocrinology

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115

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Objective: The objective of this study was to re-evaluate the adult C T reference values determined by five different immunoassays and by introducing criteria for selecting control subjects. Design: A prospective multicenter study. Patients: Three hundred and seventy-five clinically euthyroid subjects. Methods: We used five different C T immunoassays. Sera were assayed for the concentration of TSH, gastrin, procalcitonin, urea, calcium, and anti-thyroperoxidase antibodies. Results: Screening for the various potential causes of hypercalcitoninemia led to the exclusion of 23% of the sera. Our reference value analysis dealt with 287 subjects (142 men and 145 women). The proportion of samples in which no C T was detected varied from 56% (for assay D) to 88% (for assay C). We observed significant correlations (whose magnitude depended on the assay used) between C T levels and age or body mass index (BMI) (primarily in men). The distribution of C T levels showed that 4.7, 9.8, 2.5, 6.5, and 8.0% of the values were over 10 pg/ml respectively. These values corresponded essentially to samples from 11 male subjects (median age: 55 years), most of whom were smokers. The highest C T values were around twice as high in men than women, and were higher in smokers than non-smokers. Conclusion: In clinical practice (and after having excluded the usual causes of raised C T levels), the interpretation of C T assay results must take into account i) the method used; ii) the patient's gender, age, and weight; and iii) the potential influence of cigarette smoking.European Journal of Endocrinology 157 749-755

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Interest of Routine Measurement of Serum Calcitonin: Study in a Large Series of Thyroidectomized Patients

Cited by 193 publications

References 23 publications

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

Latin American Thyroid Society recommendations for the management of thyroid nodules

Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking

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