Interesting Case of Skin Metastasis in Colorectal Cancer and Review of Literature

Abstract

Skin metastasis is a complication rarely seen after curative resection for colorectal cancer and chemotherapy. The article describes a metachronous case of skin metastasis after curative resection. This article is presented to illustrate that genetic and molecular profiling of carcinoma is a must for diagnosis of aggressive biological behavior and that skin metastasis is usually a harbinger of adverse outcome.

Erythema <em>ab igne</em> masking cutaneous metastasis of colorectal adenocarcinoma

“…Other less frequent presentations include inflammatory erythema, ulcers, plaques, blisters, and teleangectasia. [4][5][6] We report an atypical morphological manifestation of erythema ab igne with an underlying cutaneous metastasis that diag- nosed based on biopsy. A thorough search in the literature resulted in only 11 reports of incidental ab igne lesions, mostly with history of heat exposure, in patients diagnosed with malignancy (Table 1).…”

“…2,3 Morphologically, cutaneous metastasis commonly manifest as subcutaneous or intradermal violaceous nodules that coalesce with a firm rubbery appearance. [4][5][6] Other reported manifestations include erythematous, plaques, bullous, and ulcerative lesions. [4][5][6] However, to the best of our knowledge, erythema ab igne-like presentation has never been reported as a feature of cutaneous metastasis.…”

“…[4][5][6] Other reported manifestations include erythematous, plaques, bullous, and ulcerative lesions. [4][5][6] However, to the best of our knowledge, erythema ab igne-like presentation has never been reported as a feature of cutaneous metastasis. We report a case of colorectal adenocarcinoma cutaneous metastasis with erythema ab igne-like morphology.…”

A Case Report: Cutaneous Metastasis of Advanced Rectal Cancer with BRAF Mutation

“…Riyadh Hakami 8 report a patient diagnosed with rectal cancer associated with extensive skin metastasis to the perineum and inguinal area, who carried the mutation c.34G>T (p.G12C) in exon 2 of the K-RAS oncogene. Besides, Amarjothi JMV 9 report a 25-year-old man with rectal adenocarcinoma with multiple peritoneal metastases, and it is not clear whether there was a BRAF mutation. However, as in our case, cutaneous metastases may also occur dramatically over a relatively short period of time.…”

Potpourri of interesting scalp lesions

“…The most common primary sites of cutaneous colorectal metastasis have been reported as follows: rectum (55%), sigmoid colon (17%), transverse colon (9%), rectosigmoid (7%), cecum (4%), and ascending colon (4%) [16].…”