Intérêt de la procalcitonine dans les infections néonatales

Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge

“…We have recently shown that both IL-6 and PCT present a natural fluctuation in the immediate postnatal period (76,86 ), necessitating very careful adjustments in the normal ranges. This may explain the conflicting cutoff points for abnormal values that have been reported for these two markers (28,38,(87)(88)(89)(90)(91)(92). We have also shown that some confounding factors, per se, should be taken into account to define "physiologic" concentrations of both IL-6 and PCT (76,86 ).…”

Relevance of Procalcitonin for the Diagnosis of Early and Late-Onset Sepsis in Newborns

“…Its increase serum level when bacterial infections have been demonstrated in 1992. These data were confirmed by a prospective pediatric study in 1993 and applied to neonatal monitoring since 1998 [7][8][9][10][11][12]. In neonatology, studies on the usefulness of PCT are controversial.…”