Intérêts dosimétriques et cliniques de la radiothérapie asservie à la respiration des cancers du poumon et du sein : résultats du Stic 2003

Giraud, P.; Djadi-Prat, Juliette; Morvan, E.; Morelle, Magali; Remmonay, R; Pourel, N.; Durdux, C.; Carrié, C.; Mornex, F.; Péchoux, C. Le; Bachaud, J.M.; Boisselier, P.; Beckendorf, V.; Dendale, R.; Daveau, C.; Garcia, R.; Stic, les centres investigateurs du

doi:10.1016/j.canrad.2012.03.005

Cited by 18 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many techniques have been proposed for DIBH radiation of left‐side breast cancer to minimize cardiac doses, including involuntary breath‐hold with active breathing control, (8) and voluntary breath‐hold using various devices 9 , 10 , 11 , 12 , 13 . McIntosh et al (13) reported voluntary deep inhalation breath‐hold using an RPM signal as a surrogate, in which 43%–60% dose reductions of cardiac doses were observed.…”

Section: Discussionmentioning

confidence: 99%

Clinical experience using a video‐guided spirometry system for deep inhalation breath‐hold radiotherapy of left‐sided breast cancer

Yang

McKenzie

Burnison

et al. 2015

J Applied Clin Med Phys

View full text Add to dashboard Cite

The purpose was to report clinical experience of a video‐guided spirometry system in applying deep inhalation breath‐hold (DIBH) radiotherapy for left‐sided breast cancer, and to study the systematic and random uncertainties, intra‐ and interfraction motion and impact on cardiac dose associated with DIBH. The data from 28 left‐sided breast cancer patients treated with spirometer‐guided DIBH radiation were studied. Dosimetric comparisons between free‐breathing (FB) and DIBH plans were performed. The distance between the heart and chest wall measured on the digitally reconstructed radiographs (DRR) and MV portal images, dDRR(DIBH) and dport(DIBH), respectively, was compared as a measure of DIBH setup uncertainty. The difference (Δd) between dDRR(DIBH) and dport(DIBH) was defined as the systematic uncertainty. The standard deviation of Δd for each patient was defined as the random uncertainty. MV cine images during radiation were acquired. Affine registrations of the cine images acquired during one fraction and multiple fractions were performed to study the intra‐ and interfraction motion of the chest wall. The median chest wall motion was used as the metric for intra‐ and interfraction analysis. Breast motions in superior–inferior (SI) direction and “AP” (defined on the DRR or MV portal image as the direction perpendicular to the SI direction) are reported. Systematic and random uncertainties of 3.8 mm and 2 mm, respectively, were found for this spirometer‐guided DIBH treatment. MV cine analysis showed that intrafraction chest wall motions during DIBH were 0.3 mm in “AP” and 0.6 mm in SI. The interfraction chest wall motions were 3.6 mm in “AP” and 3.4 mm in SI. Utilization of DIBH with this spirometry system led to a statistically significant reduction of cardiac dose relative to FB treatment. The DIBH using video‐guided spirometry provided reproducible cardiac sparing with minimal intra‐ and interfraction chest wall motion, and thus is a valuable adjunct to modern breast treatment techniques.PACS number: 87.55.kh, 87.55.ne, 87.55.tg

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical experience using a video‐guided spirometry system for deep inhalation breath‐hold radiotherapy of left‐sided breast cancer

Yang

McKenzie

Burnison

et al. 2015

J Applied Clin Med Phys

View full text Add to dashboard Cite

show abstract

“…In addition, although patients with COPD or COPDAE with stages IIIA-IIIB lung SCC receive de nitive CCRT, radiation oncologists might consider more precision RT techniques, including image-guided radiation therapy, respirator gating, and other respiratory control techniques, for reducing RILI and ensuring low irradiation to normal lung, heart, and esophageal tissues to prevent acute or late radiation-induced pulmonary, cardiac, and esophageal toxicities in these patients. [56,57] This study has some limitations. First, toxicity induced by different treatments could not be determined; therefore, treatment-related mortality estimates may have been biased.…”

Section: Discussionmentioning

confidence: 95%

Impact of Chronic Obstruction Pulmonary Disease with Acute Exacerbation on Survival in Current-Smoking Patients with Advanced stages Lung Squamous Cell Carcinoma undergoing Concurrent Chemoradiotherapy

Chiu¹,

Lin²,

Chang³

et al. 2021

Preprint

View full text Add to dashboard Cite

BACKGROUNDTo date, no data are available regarding the effect of chronic obstruction pulmonary disease (COPD) and COPD with acute exacerbation (COPDAE) on survival in patients with lung squamous cell carcinoma (SCC) receiving definitive concurrent chemoradiotherapy (CCRT).PATIENTS AND METHODSCurrent-smoking patients with clinical stage IIIA-IIIB, lung SCC who had received standard definitive CCRT and categorized them into two groups based on their COPD status to compare overall survival outcomes. We also examined the effects of COPD severity (0, 1, or ≥2 hospitalizations for COPDA within 1 year before CCRT). The aHRs (95% CIs) of lung cancer death for 1 and ≥2 hospitalizations for COPDAE within 1 year before CCRT were 1.21 (1.09, 1.39) and 1.63 (1.34, 1.97), respectively, compared with no hospitalization for COPDAE.RESULTSIn the inverse probability of treatment weighting (IPTW)-adjusted model, the adjusted hazard ratio (aHR) (95% confidence interval [CI]) of all-cause death for COPD was 1.06 (1.07, 1.71) compared with the non-COPD group. Moreover, in the IPTW-adjusted model, the aHRs (95% CIs) of 1 and ≥2 hospitalizations for COPDAE within 1 year before CCRT were 1.29 (1.16, 1.43) and 1.77 (1.41, 2.13), respectively, compared with no hospitalization for COPDAE.CONCLUSIONCOPD and its severity are significant independent risk factors for all-cause death in patients with stage IIIA-IIIB lung SCC receiving definitive CCRT. Hospitalization for COPDAE within 1 year before CCRT is the significant independent risk factors for lung cancer death in the patients with stages IIIA-IIIB lung SCC receiving definitive CCRT.

show abstract

“…High-precision radiotherapy (HPR), i.e., intensity-modulated radiation therapy (IMRT), has steadily established its role in cancer treatment. Increasing clinical data have shown the advantage of HPR due to its excellent dose distribution in the target volume and sparing of normal tissues1234. Compared to conventional external beam radiotherapy (EBRT), HPR usually requires more fraction delivery time (FDT) due to the more complicated delivery process (approximately 1 to 3 minutes for conventional EBRT and 15 minutes or more for HPR, i.e., prospective respiratory gating Image-guided IMRT usually takes more than 50 minutes to deliver the same fraction dose).…”

mentioning

confidence: 99%

Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagy

Yao

Zheng

Xie

et al. 2015

Sci Rep

View full text Add to dashboard Cite

High-precision radiotherapy (HPR) has established its important role in the treatment of tumors due to its precise dose distribution. Given its more complicated delivery process, HPR commonly requires more fraction delivery time (FDT). However, it is unknown whether it has an identical response of prolonged FDT on different normal tissues. Our results showed that fractionated irradiation with prolonged FDTs (15, 36, and 50 minutes) enhanced cell surviving fractions for normal tissue cells compared with irradiation with an FDT of 2 minutes. However, the late-responding normal cell line HEI-OC1 was more responsive to prolonged FDTs and demonstrated higher surviving fractions and significantly decreased apoptosis and DNA damage compared to the acute-responding normal cell line HaCaT. Increased autophagy mediated via the ATM-AMPK pathway was observed in HEI-OC1 cells compared with HaCaT cells when irradiated with prolonged FDTs. Furthermore, treatment with the autophagy inhibitor 3-MA or ATM inhibitor KU55933 resulted in enhanced ROS accumulation and attenuation of the effect of prolonged FDT-mediated protection on irradiated HEI-OC1 cells. Our results indicated that late-responding normal tissue cells benefitted more from prolonged FDTs compared with acute-responding tissue cells, which was mainly attributed to enhanced cytoprotective autophagy mediated via the ATM/AMPK signaling pathway.

show abstract

Intérêts dosimétriques et cliniques de la radiothérapie asservie à la respiration des cancers du poumon et du sein : résultats du Stic 2003

Cited by 18 publications

References 27 publications

Clinical experience using a video‐guided spirometry system for deep inhalation breath‐hold radiotherapy of left‐sided breast cancer

Clinical experience using a video‐guided spirometry system for deep inhalation breath‐hold radiotherapy of left‐sided breast cancer

Impact of Chronic Obstruction Pulmonary Disease with Acute Exacerbation on Survival in Current-Smoking Patients with Advanced stages Lung Squamous Cell Carcinoma undergoing Concurrent Chemoradiotherapy

Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagy

Contact Info

Product

Resources

About