Interface crosslinked mPEG-b-PAGE-b-PCL triblock copolymer micelles with high stability for anticancer drug delivery

Lu, Yujie; Gao, Xuedi; Cao, Ming; Wu, Bin; Su, Lifen; Chen, Peng; Miao, Jibin; Wang, Song; Xia, Ru; Qian, Jiasheng

doi:10.1016/j.colsurfb.2020.110830

Cited by 23 publications

(17 citation statements)

References 36 publications

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“…In this field, Lu et al synthesized an amphiphilic triblock copolymer, (mPEG‐b‐PAGE‐b‐PCL), to improve micelle stability, so that the micelles were crosslinked by a thiol‐ene reaction. 58 . The stability of cross‐linked micelles was tested by monitoring their size variation.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of doxorubicin‐loaded PBMA‐b‐POEGMA micelles and assessment of its anticancer activity against breast cancer cells (4T1)

Gharnas-ghamesh

Masoumi

Erfani‐Moghadam

2022

J of Applied Polymer Sci

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Doxorubicin (DOX) is a chemotherapy drug that possesses many side effects. This study aimed to synthesize PBMA‐b‐POEGMA [poly (butyl methacrylate)‐b‐poly (oligo ethylene glycol methacrylate)] diblock copolymer as a nanocarrier for loading of DOX, promoting anticancer efficacy of the drug, and decreasing its side effects. Hence, PBMA‐b‐POEGMA diblock copolymer was first synthesized by the RAFT method and then DOX encapsulated into the micellar nanocarrier. Self‐assembly behavior of copolymers and physicochemical/biological properties of nanocarriers were assessed. DLS and TEM images showed nanocarriers possessed spherical‐uniform structure with the mean size and polydispersity of 27 ± 1.34 nm and 0.13 ± 0.21 for blank‐micelles as well as, 45 ± 2.32 nm and 0.18 ± 0.18 for DOX‐loaded micelles, respectively. Synthesized micelles also provided high drug encapsulation efficiency (>80%) with a drug loading content of 4.53%. Moreover, the maximum released amount of drug was reported at 69%, with the Korsmeyer‐Peppas model, as a more suitable model to describe the release behavior of DOX from nanocarriers. Biologically, block copolymers were biocompatible against COS‐7 and 4T1 cell lines, in addition, free‐DOX showed higher cytotoxicity than DOX‐loaded micelles. Furthermore, 0.5 μg/mL concentration of drug‐loaded micelle led to growth inhibition of more than 60% of cancerous cells, during 48 h, so that higher level of cellular uptake of drug and apoptosis in 4T1 cells was induced by drug‐loaded micelles.

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Section: Resultsmentioning

confidence: 99%

Synthesis of doxorubicin‐loaded PBMA‐b‐POEGMA micelles and assessment of its anticancer activity against breast cancer cells (4T1)

Gharnas-ghamesh

Masoumi

Erfani‐Moghadam

2022

J of Applied Polymer Sci

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“…To overcome these limitations, controlled drug delivery systems are being explored in different applications, specially cancer treatment. Controlled delivery of therapeutic agents such as Paclitaxel, Methotrexate, Stattic, Doxorubicin, and Cisplatin have been demonstrated with the use of PLGAbased nanoplatforms, silica nanoparticles, and pendant-dendron amphiphilic copolymer (P71D3)-based polymeric micelles and high tumor concentration of the therapeutic agent can complement controlled and targeted delivery through conjugating the therapeutic agents with tumor targeting antibodies or peptides [14][15][16][17]36].…”

Section: Discussionmentioning

confidence: 99%

“…A variety of drug delivery systems have been studied so far; namely: polymeric micelles, liposomes, nanoparticles, hydrogels, bioactive membranes, and electrospun nanofibers [11][12][13][14][15][16][17]. Strategies for drug encapsulation and release can range from simple loading in a polymeric carrier and providing release through a combination of diffusion, surface hydrolysis and degradation of the matrix or a more controlled approach using stimuli responsive (pH, redox, oxidation and enzyme concentration) or remote controlled (magnetic field, temperature, light intensity and ultrasound frequency) systems [18,19].…”

Section: Introductionmentioning

confidence: 99%

Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells

et al. 2020

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Renal Cell Carcinoma (RCC) often becomes resistant to targeted therapies, and in addition, dose-dependent toxicities limit the effectiveness of therapeutic agents. Therefore, identifying novel drug delivery approaches to achieve optimal dosing of therapeutic agents can be beneficial in managing toxicities and to attain optimal therapeutic effects. Previously, we have demonstrated that Honokiol, a natural compound with potent anti-tumorigenic and anti-inflammatory effects, can induce cancer cell apoptosis and inhibit the growth of renal tumors in vivo. In cancer treatment, implant-based drug delivery systems can be used for gradual and sustained delivery of therapeutic agents like Honokiol to minimize systemic toxicity. Electrospun polymeric fibrous scaffolds are ideal candidates to be used as drug implants due to their favorable morphological properties such as high surface to volume ratio, flexibility and ease of fabrication. In this study, we fabricated Honokiol-loaded Poly(lactide-co-glycolide) (PLGA) electrospun scaffolds; and evaluated their structural characterization and biological activity. Proton nuclear magnetic resonance data proved the existence of Honokiol in the drug loaded polymeric scaffolds. The release kinetics showed that only 24% of the loaded Honokiol were released in 24hr, suggesting that sustained delivery of Honokiol is feasible. We calculated the cumulative concentration of the Honokiol released from the scaffold in 24hr; and the extent of renal cancer cell apoptosis induced with the released Honokiol is similar to an equivalent concentration of direct application of Honokiol. Also, Honokiol-loaded scaffolds placed directly in renal cell culture inhibited renal cancer cell proliferation and migration. Together, we demonstrate that Honokiol delivered through electrospun PLGA-based scaffolds is effective in inhibiting the growth of renal cancer cells; and our data necessitates further in vivo studies to explore the potential of sustained release of therapeutic agents-loaded electrospun scaffolds in the treatment of RCC and other cancer types.

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“…Therefore, strategies such as crosslinking the micelle core has been developed to improve micelle stability in the blood (Cajot et al, 2011). However, cross-linking the core of the micelle may decrease the drug loading capacity, therefore, other methods such as interface crosslinking may be more suitable (Lu et al, 2020).…”

Section: Micelles As Anti-osteosarcoma Nanocarriersmentioning

confidence: 99%

The Application of 3D-Printing and Nanotechnology for the Targeted Treatment of Osteosarcoma

et al. 2021

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Osteosarcoma is a malignant bone neoplasm prevalent in adolescents. Current therapies include chemotherapy and surgery. Surgical resection of osteosarcoma induces a large bone defect which may be overcome by employing scaffolds for bone tissue engineering. This review details the polymers and bioceramics that may be used to fabricate 3D printed scaffolds for bone regeneration and the nanotechnology strategies that may be incorporated into such scaffolds. Natural polymers discussed include chitosan, alginate, collagen, gelatin, and silk fibroin. Synthetic polymers discussed include polycaprolactone, polyurethane, poly(lactic)acid and poly(vinyl) alcohol. Bioceramics that are utilized in bone regeneration such as calcium phosphate, calcium silicate and bioglass are elaborated on. Furthermore, comparison data between different types of 3D printed scaffolds for bone regeneration are presented. A discussion on Photo-responsive and magneto-responsive 3D printed scaffolds that have been fabricated for bone regeneration is included. Research concerning drug-loaded scaffolds as well as the incorporation of nanocarriers into scaffolds for bone regeneration is provided. Chemotherapy utilized in osteosarcoma therapy has severe adverse effects due to being non-selective between healthy cells and tumor cells. A possible way to overcome this is to utilize nanotechnology. Therefore, research detailing other types of nanocarriers that have the potential to be incorporated into 3D printed scaffolds for localized adjuvant therapy is presented.

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Interface crosslinked mPEG-b-PAGE-b-PCL triblock copolymer micelles with high stability for anticancer drug delivery

Cited by 23 publications

References 36 publications

Synthesis of doxorubicin‐loaded PBMA‐b‐POEGMA micelles and assessment of its anticancer activity against breast cancer cells (4T1)

Synthesis of doxorubicin‐loaded PBMA‐b‐POEGMA micelles and assessment of its anticancer activity against breast cancer cells (4T1)

Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells

The Application of 3D-Printing and Nanotechnology for the Targeted Treatment of Osteosarcoma

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