Interface healing and its correlation with visual recovery and quality of vision following small incision lenticule extraction

Ganesh, Sri; Brar, Sheetal; Pandey, Rahul; Pawar, Archana

doi:10.4103/ijo.ijo_775_17

Cited by 16 publications

(5 citation statements)

References 24 publications

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“…properties of a lenticular graft, early visual recovery, and visual quality (29,31). AFM images obtained in the study, although not directly comparable due to differences in scale, demonstrated the presence of nanometre scale imperfections which was concordant with SEM images obtained.…”

Section: Discussionsupporting

confidence: 75%

“…Upon thawing and implantation of the lenticules, it predisposed patients to several complications, including corneal oedema and an increase in astigmatism (26)(27)(28). Incisional surface quality is important for early visual recovery following corneal refractive surgeries (29)(30)(31). For example, a prospective non-randomized study conducted on patients undergoing SMILE found that surface interface roughness was inversely associated with corrected distance visual acuity (CDVA) (31).…”

Section: Introductionmentioning

confidence: 99%

“…Incisional surface quality is important for early visual recovery following corneal refractive surgeries (29)(30)(31). For example, a prospective non-randomized study conducted on patients undergoing SMILE found that surface interface roughness was inversely associated with corrected distance visual acuity (CDVA) (31). This effect was observed only on the one-day post-operative follow-up as the surface irregularities may reduce due to stromal collagen remodeling postoperatively.…”

Section: Introductionmentioning

confidence: 99%

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Incisional surface quality of electron-beam irradiated cornea-extracted lenticule for stromal keratophakia: high nJ-energy vs. low nJ-energy femtosecond laser

Chan,

Han,

Lim

et al. 2023

Front. Med.

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IntroductionCorneal lenticules can be utilized as an additive material for stromal keratophakia. However, following extraction, they must be reimplanted almost immediately or cryopreserved in lenticule banks. Electron-beam (E-beam) irradiated corneas permit room-temperature storage for up to 2 years, enabling keratophakia to be performed on demand. This study aims to compare the performance of high nano Joule (nJ)-energy (VisuMax) and low nJ-energy (FEMTO LDV) femtosecond laser systems on the thickness consistency and surface quality and collagen morphology of lenticules produced from fresh and E-beamed corneas.MethodsA total of 24 lenticules with −6.00 dioptre power were cut in fresh human donor corneas and E-beamed corneas with VisuMax and FEMTO LDV. Before extraction, the thickness of the lenticules was measured with anterior segment-optical coherence tomography (AS-OCT). The incisional surface roughness of extracted lenticules was analyzed using atomic force microscopy (AFM) and scanning electron microscopy (SEM). Multiphoton microscopy was then used to assess the surface collagen morphometry.ResultsThe E-beamed lenticules that were cut using FEMTO LDV were significantly thicker than the fresh specimens as opposed to those created with VisuMax, which had a similar thickness as the fresh lenticules. On the vertex, they were ∼11% thicker than the fresh lenticules. The surface roughness (Rq) of E-beamed lenticules incised with FEMTO LDV did not differ significantly from the fresh lenticules. This contrasted with the VisuMax-fashioned lenticules, which showed notably smoother surfaces (∼36 and ∼20% lower Rq on anterior and posterior surfaces, respectively) on the E-beamed than the fresh lenticules. The FEMTO LDV induced less cumulative changes to the collagen morphology on the surfaces of both fresh and E-beamed lenticules than the VisuMax.ConclusionIt has been previously demonstrated that the low nJ-energy FEMTO LDV produced a smoother cutting surface compared to high nJ-energy VisuMax in fresh lenticules. Here, we showed that this effect was also seen in the E-beamed lenticules. In addition, lower laser energy conferred fewer changes to the lenticular surface collagen morphology. The smaller disparity in surface cutting quality and collagen disturbances on the E-beamed lenticules could be beneficial for the early visual recovery of patients who undergo stromal keratophakia.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incisional surface quality of electron-beam irradiated cornea-extracted lenticule for stromal keratophakia: high nJ-energy vs. low nJ-energy femtosecond laser

Chan,

Han,

Lim

et al. 2023

Front. Med.

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“…Visual cognition is to use vision to distinguish, understand, and judge what you see. In this process, in addition to the visually acquired information, it also needs the human brain to process the acquired information many times to get the overall situation of things [5]. Manmachine interface is an important component of manmachine interaction technology, which displays various visual information to provide the basis for users' judgment.…”

Section: Introductionmentioning

confidence: 99%

Human-Machine Interface Visual Communication Design Model of Electronic Equipment Using Machine Vision Technology

Hao

Chung

2022

Wireless Communications and Mobile Computing

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Electronic equipment has high precision, high reliability, high stability, and high security, as well as the ability to adapt to a variety of challenging environments. With the rapid advancement of mechanization, automation, and electronization, the impact of human factors in production is growing, and designers are increasingly concerned about the problem of man-machine coordination. It is critical to have a man-machine interface that is suitable for operators’ thinking and behavior and has a guiding function. The accuracy and timeliness of equipment control are linked to the human-computer interaction interface. The visual characteristics of human cone cells are used to divide the neural visual perception intensity grades. With the visual communication index as the optimization goal, a mathematical model of human-computer interaction interface optimization is established and solved using a genetic algorithm. This method is used to optimize the design of a human-computer interaction interface, and the results show that the visual communication index of the optimized human-computer interaction interface has improved significantly.

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“…But it is not only the energy that is responsible for roughness; spot placement (spacings) also plays an important role, as demonstrated for excimer based corneal ablations [20,21]. Interface roughness after laser vision correction has been associated with lower postoperative visual acuity for both femtosecond-based treatments (lenticule extraction) [22], and excimer-based corneal ablations [23] whereas simulations show that random and patterned roughness induce distinct effects in visual perception [24]. Apparently, refraction (myopia vs. hyperopia) does not seem to play a major role in the induced roughness [25], but the depth of the cut in the tissue does [26].…”

Section: Discussionmentioning

confidence: 99%

Optimization of the Spot Spacings for Reducing Roughness in Laser-Induced Optical Breakdown Processes for Corneal Laser Vision Correction

Amann,

Arba Mosquera

2024

Photonics

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The aim of this work is to implement an algorithm that simulates a simplified cutting surface based on laser-induced optical breakdown (LIOB). The algorithm includes the definition of a possible positioning of the laser pulses and calculation of the roughness for different parameter settings (including LIOB threshold, pulse energies, and spot spacings) as the difference between simulated and ideal target cut (local differences within the cut, i.e., the waviness of the simulated cut vs. the homogeneity of the ideal target cut). Furthermore, optimizations of specific variables, such as spot distance (along the pathway), track distance (between lines/tracks), and pulse energy, are performed. The simulations suggest that lower pulse energies (well above the LIOB threshold) combined with asymmetric spacings (spot-to-track distance ratio >> 1) may be effective to lower the roughness of laser cuts generated by LIOB processes. The importance of lowering pulse energies (well above the threshold) emphasizes the need for the LIOB threshold to remain low (as low as possible). Reducing roughness by decreasing spacings (thus, increasing dose for same pulse energies) may have negative implications in visual recovery (risk for overdose). In all cases, the roughness is multiple times larger (rougher) than equivalent simulations for ablative procedures.

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Interface healing and its correlation with visual recovery and quality of vision following small incision lenticule extraction

Cited by 16 publications

References 24 publications

Incisional surface quality of electron-beam irradiated cornea-extracted lenticule for stromal keratophakia: high nJ-energy vs. low nJ-energy femtosecond laser

Incisional surface quality of electron-beam irradiated cornea-extracted lenticule for stromal keratophakia: high nJ-energy vs. low nJ-energy femtosecond laser

Human-Machine Interface Visual Communication Design Model of Electronic Equipment Using Machine Vision Technology

Optimization of the Spot Spacings for Reducing Roughness in Laser-Induced Optical Breakdown Processes for Corneal Laser Vision Correction

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