Interface Micromotion of Uncemented Femoral Components from Postmortem Retrieved Total Hip Replacements

Mann, Kenneth A.; Miller, Mark A.; Costa, Peter A.; Race, Amos; Izant, Timothy H.

doi:10.1016/j.arth.2011.04.018

Cited by 8 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found higher micromotion in torsion (stair climbing) than in compression (walking). This result compares well with results from Enoksen et al (2014) and Kassi et al (2005) obtained with LVDTs or with measurements from postmortem retrieval sections by Mann et al (2012). The patterns of micromotion revealed that for axial compression, micromotion was low proximally and high distally.…”

Section: Discussionsupporting

confidence: 77%

Full-field measurement of micromotion around a cementless femoral stem using micro-CT imaging and radiopaque markers

Camine

Rüdiger

Pioletti

et al. 2016

Journal of Biomechanics

View full text Add to dashboard Cite

a b s t r a c tA good primary stability of cementless femoral stems is essential for the long-term success of total hip arthroplasty. Experimental measurement of implant micromotion with linear variable differential transformers is commonly used to assess implant primary stability in pre-clinical testing. But these measurements are often limited to a few distinct points at the interface. New techniques based on microcomputed tomography (micro-CT) have recently been introduced, such as Digital Volume Correlation (DVC) or markers-based approaches. DVC is however limited to measurement around non-metallic implants due to metal-induced imaging artifacts, and markers-based techniques are confined to a small portion of the implant. In this paper, we present a technique based on micro-CT imaging and radiopaque markers to provide the first full-field micromotion measurement at the entire bone-implant interface of a cementless femoral stem implanted in a cadaveric femur. Micromotion was measured during compression and torsion. Over 300 simultaneous measurement points were obtained. Micromotion amplitude ranged from 0 to 24 mm in compression and from 0 to 49 mm in torsion. Peak micromotion was distal in compression and proximal in torsion. The technique bias was 5.1 mm and its repeatability standard deviation was 4 mm. The method was thus highly reliable and compared well with results obtained with linear variable differential transformers (LVDTs) reported in the literature. These results indicate that this micro-CT based technique is perfectly relevant to observe local variations in primary stability around metallic implants. Possible applications include pre-clinical testing of implants and validation of patient-specific models for pre-operative planning.

show abstract

Section: Discussionsupporting

confidence: 77%

Full-field measurement of micromotion around a cementless femoral stem using micro-CT imaging and radiopaque markers

Camine

Rüdiger

Pioletti

et al. 2016

Journal of Biomechanics

View full text Add to dashboard Cite

show abstract

“…We developed a new in vitro model for bone implant loosening, which is able to simulate supraphysiological loading as it occurs in the peri‐prosthetic interface in patients undergoing prosthetic revision surgery, but also determined using human samples post‐mortem . In this new model, we demonstrated that similar pathophysiological mechanisms are involved in overloading‐induced and stress‐shielding related bone loss, which have been discussed previously in animal models for instability‐induced prosthetic loosening, where a high fluid flow rate at the peri‐implant surface was associated with enhanced osteoclast differentiation and bone loss .…”

Section: Discussionmentioning

confidence: 68%

“…Soluble factors were released in the conditioned medium after treatment of the cells with this supraphysiological loading regime, which induced osteoclast differentiation. The main difference between the sinusoidal and square wave loading regimes used in this study are the flow velocity and the shear stress rate, which play an important role in the activation of bone cells, as well as in the loosening of prostheses …”

Section: Discussionmentioning

confidence: 99%

Supraphysiological loading induces osteocyte‐mediated osteoclastogenesis in a novel in vitro model for bone implant loosening

Fahlgren

Bratengeier

Semeins

et al. 2017

Journal Orthopaedic Research

View full text Add to dashboard Cite

We aimed to develop an in vitro model for bone implant loosening, allowing analysis of biophysical and biological parameters contributing to mechanical instability-induced osteoclast differentiation and peri-implant bone loss. MLO-Y4-osteocytes were mechanically stimulated for 1 h by fluid shear stress using regimes simulating: (i) supraphysiological loading in the peri-prosthetic interface (2.9 ± 2.9 Pa, 1 Hz, square wave); (ii) physiologic loading in the cortical bone (0.7 ± 0.7 Pa, 5 Hz, sinusoidal wave); and (iii) stress shielding. Cellular morphological parameters, membrane-bound RANKL expression, gene expression influencing osteoclast differentiation, nitric oxide release and caspase 3/7-activity were determined. Either Mouse bone marrow cells were cultured on top of loaded osteocytes or osteocyte-conditioned medium was added to bone marrow cells. Osteoclast differentiation was assessed after 6 days. We found that osteocytes subjected to supraphysiological loading showed similar morphology and caspase 3/7-activity compared to simulated physiological loading or stress shielding. Supraphysiological stimulation of osteocytes enhanced osteoclast differentiation by 1.9-fold compared to physiological loading when cell-to-cell contact was permitted. In addition, it enhanced the number of osteoclasts using conditioned medium by 1.7-fold, membrane-bound RANKL by 3.3-fold, and nitric oxide production by 3.2-fold. The stimulatory effect of supraphysiological loading on membrane-bound RANKL and nitric oxide production was higher than that achieved by stress shielding. In conclusion, the in vitro model developed recapitulated the catabolic biological situation in the peri-prosthetic interface during instability that is associated with osteoclast differentiation and enhanced RANKL expression. The model thus provides a platform for pre-clinical testing of pharmacological interventions with potential to stop instability-induced bone implant loosening. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1425-1434, 2018.

show abstract

“… 16 The relationship between bone-implant contact and micromotions was also demonstrated on transverse sections of retrievals of uncemented hips under gait and stair-climbing test conditions. 29 It was also observed that micromotions alter osteoblast activity. However, it is not only the question of whether bone formation is taking place but also of how the bone is remodelled and the bone architecture altered in the implant periphery.…”

Section: Discussionmentioning

confidence: 99%

Effects of interfacial micromotions on vitality and differentiation of human osteoblasts

Ziebart

Fan

Schulze

et al. 2018

Bone & Joint Research

View full text Add to dashboard Cite

ObjectivesEnhanced micromotions between the implant and surrounding bone can impair osseointegration, resulting in fibrous encapsulation and aseptic loosening of the implant. Since the effect of micromotions on human bone cells is sparsely investigated, an in vitro system, which allows application of micromotions on bone cells and subsequent investigation of bone cell activity, was developed.MethodsMicromotions ranging from 25 µm to 100 µm were applied as sine or triangle signal with 1 Hz frequency to human osteoblasts seeded on collagen scaffolds. Micromotions were applied for six hours per day over three days. During the micromotions, a static pressure of 527 Pa was exerted on the cells by Ti6Al4V cylinders. Osteoblasts loaded with Ti6Al4V cylinders and unloaded osteoblasts without micromotions served as controls. Subsequently, cell viability, expression of the osteogenic markers collagen type I, alkaline phosphatase, and osteocalcin, as well as gene expression of osteoprotegerin, receptor activator of NF-κB ligand, matrix metalloproteinase-1, and tissue inhibitor of metalloproteinase-1, were investigated.ResultsLive and dead cell numbers were higher after 25 µm sine and 50 µm triangle micromotions compared with loaded controls. Collagen type I synthesis was downregulated in respective samples. The metabolic activity and osteocalcin expression level were higher in samples treated with 25 µm micromotions compared with the loaded controls. Furthermore, static loading and micromotions decreased the osteoprotegerin/receptor activator of NF-κB ligand ratio.ConclusionOur system enables investigation of the behaviour of bone cells at the bone-implant interface under shear stress induced by micromotions. We could demonstrate that micromotions applied under static pressure conditions have a significant impact on the activity of osteoblasts seeded on collagen scaffolds. In future studies, higher mechanical stress will be applied and different implant surface structures will be considered.Cite this article: J. Ziebart, S. Fan, C. Schulze, P. W. Kämmerer, R. Bader, A. Jonitz-Heincke. Effects of interfacial micromotions on vitality and differentiation of human osteoblasts. Bone Joint Res 2018;7:187–195. DOI: 10.1302/2046-3758.72.BJR-2017-0228.R1.

show abstract

Interface Micromotion of Uncemented Femoral Components from Postmortem Retrieved Total Hip Replacements

Cited by 8 publications

References 25 publications

Full-field measurement of micromotion around a cementless femoral stem using micro-CT imaging and radiopaque markers

Full-field measurement of micromotion around a cementless femoral stem using micro-CT imaging and radiopaque markers

Supraphysiological loading induces osteocyte‐mediated osteoclastogenesis in a novel in vitro model for bone implant loosening

Effects of interfacial micromotions on vitality and differentiation of human osteoblasts

Contact Info

Product

Resources

About