A study on the interface monotonic shear behavior of calcareous sands reinforced with geogrid was reported. Large-scale monotonic direct shear tests were carried out on calcareous sand samples with and without geogrid. The interface shear behavior was investigated by considering the effects of normal stresses ranging from 25 to 100 kPa and relative densities ranging from 50 to 90%. The results demonstrate that the shear strength of geogrid-reinforced calcareous sand (GRCS) and unreinforced calcareous sand accords with the Mohr-Coulomb strength theory. The shear stress-shear displacement curve presents significant strain-softening behavior, and has experienced elasto-plastic stage, softening stage, residual stage. When the relative density is 50%, 70%, and 90%, the interface peak cohesion of GRCS is increased by 1.6 times, 1.9 times, and 1.4 times compared with the unreinforced calcareous sand, and the interface peak internal friction angle is increased by 1.2 times, 1.1 times, and 1.0 times, respectively. Furthermore, under different normal stresses and relative densities, the interface friction coefficient and the reinforcement effect coefficient are both greater than 1.0, indicating that the geogrid reinforcement can improve the shear strength of calcareous sand.