Interfacial and emulsion stabilising properties of amphiphilic water-soluble poly(ethylene glycol)–poly(lactic acid) copolymers for the fabrication of biocompatible nanoparticles

Gref, Ruxandra; Babak, Valéry G.; Bouillot, Philippe; Lukina, I. G.; Bodorev, M. M.; Dellacherie, Édith

doi:10.1016/s0927-7757(98)00524-x

Cited by 28 publications

(31 citation statements)

References 12 publications

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“…Furthermore, the experimental findings in Fig. 9 are consistent, e.g., with the findings of Gref et al on the emulsion stabilization properties of these copolymers (44).…”

Section: Effect Of Degradation On Steric Stabilizationsupporting

confidence: 91%

“…Stolnik et al also investigated the adsorption of another such copolymer in an additional study and found comparable values for the adsorption and the layer thickness as observed in the present study, given that the systems are not identical (46). Moreover, Gref et al studied the capacity of poly(ethylene glycol)-poly(lactide) copolymers to stabilize emulsion droplets (44). Analogous to the findings of the present investigation, these authors observed that the stabilizing capacity of these copolymers increases with an increasing length of the hydrophobic lactide block.…”

Section: Effect Of Degradation On Steric Stabilizationsupporting

confidence: 80%

See 1 more Smart Citation

Adsorption of Poly(ethylene oxide)–Poly(lactide) Copolymers. Effects of Composition and Degradation

Muller¹,

Carlsson²,

Malmsten

2001

Journal of Colloid and Interface Science

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“…Furthermore, the experimental findings in Fig. 9 are consistent, e.g., with the findings of Gref et al on the emulsion stabilization properties of these copolymers (44).…”

Section: Effect Of Degradation On Steric Stabilizationsupporting

confidence: 91%

Section: Effect Of Degradation On Steric Stabilizationsupporting

confidence: 80%

Adsorption of Poly(ethylene oxide)–Poly(lactide) Copolymers. Effects of Composition and Degradation

Muller¹,

Carlsson²,

Malmsten

2001

Journal of Colloid and Interface Science

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“…57 Depending on their surface density, PEG blocks have brush-like (elongated coil, high density) or mushroom-like (random coil, low density) conformations. 66,68 PEG surfaces in brush-like and intermediate configurations reduced phagocytosis and complement activation, whereas PEG surfaces in mushroom-like configuration were potent complement activators and favored phagocytosis. 32,47,69,70 Based on the Alexander-de Gennes model, the distance between PEG chains should be around 1 nm to repel small globular proteins (approximately 2 nm radius) and 1.5 nm to repel large ones (6-8 nm).…”

Section: Nanoparticle Preparationmentioning

confidence: 95%

“…65 PEG conformation at the PLA-PEG nanoparticle surface is of utmost importance for the opsoninrepelling function of the PEG layer and has been extensively studied. [57][58][59]66,68 The PEG layer thickness depends on the PEG molecular weight and surface density. 57 Depending on their surface density, PEG blocks have brush-like (elongated coil, high density) or mushroom-like (random coil, low density) conformations.…”

Section: Nanoparticle Preparationmentioning

confidence: 99%

Drug transport to brain with targeted nanoparticles

2005

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Summary: Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50 -300 nm generally). They cannot freely diffuse through the bloodbrain barrier (BBB) and require receptor-mediated transport through brain capillary endothelium to deliver their content into the brain parenchyma. Polysorbate 80-coated polybutylcyanoacrylate nanoparticles can deliver drugs to the brain by a still debated mechanism. Despite interesting results these nanoparticles have limitations, discussed in this review, that may preclude, or at least limit, their potential clinical applications. Long-circulating nanoparticles made of methoxypoly(ethylene glycol)-polylactide or poly(lactide-co-glycolide) (mPEG-PLA/ PLGA) have a good safety profiles and provide drug-sustained release. The availability of functionalized PEG-PLA permits to prepare target-specific nanoparticles by conjugation of cell surface ligand. Using peptidomimetic antibodies to BBB transcytosis receptor, brain-targeted pegylated immunonanoparticles can now be synthesized that should make possible the delivery of entrapped actives into the brain parenchyma without inducing BBB permeability alteration. This review presents their general properties (structure, loading capacity, pharmacokinetics) and currently available methods for immunonanoparticle preparation.

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“…The corona morphology of PEG is often described by mushroom (random coil, low density), brush (elongated coil, high density), or mushroom/ brush transition models. [54][55][56] PEG coronas in brush-like and intermediate configurations inhibit phagocytosis and complement activation, whereas mushroom-like PEG morphology triggers complement activation and phagocytosis. Therefore, the molecular weight and shape of PEG, as well as the PEG/PLGA molar ratio, play critical roles in the behavior of PEGylated nanoparticles.…”

Section: Pegylated Plga Nanoparticlesmentioning

confidence: 99%

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Sah¹,

Thoma²,

Desu³

et al. 2013

IJN

198

127

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Abstract:The functionality of bare polylactide-co-glycolide (PLGA) nanoparticles is limited to drug depot or drug solubilization in their hard cores. They have inherent weaknesses as a drug-delivery system. For instance, when administered intravenously, the nanoparticles undergo rapid clearance from systemic circulation before reaching the site of action. Furthermore, plain PLGA nanoparticles cannot distinguish between different cell types. Recent research shows that surface functionalization of nanoparticles and development of new nanoparticulate dosage forms help overcome these delivery challenges and improve in vivo performance. Immense research efforts have propelled the development of diverse functional PLGA-based nanoparticulate delivery systems. Representative examples include PEGylated micelles/nanoparticles (PEG, polyethylene glycol), polyplexes, polymersomes, core-shelltype lipid-PLGA hybrids, cell-PLGA hybrids, receptor-specific ligand-PLGA conjugates, and theranostics. Each PLGA-based nanoparticulate dosage form has specific features that distinguish it from other nanoparticulate systems. This review focuses on fundamental concepts and practices that are used in the development of various functional nanoparticulate dosage forms. We describe how the attributes of these functional nanoparticulate forms might contribute to achievement of desired therapeutic effects that are not attainable using conventional therapies. Functional PLGA-based nanoparticulate systems are expected to deliver chemotherapeutic, diagnostic, and imaging agents in a highly selective and effective manner.

show abstract

Interfacial and emulsion stabilising properties of amphiphilic water-soluble poly(ethylene glycol)–poly(lactic acid) copolymers for the fabrication of biocompatible nanoparticles

Cited by 28 publications

References 12 publications

Adsorption of Poly(ethylene oxide)–Poly(lactide) Copolymers. Effects of Composition and Degradation

Adsorption of Poly(ethylene oxide)–Poly(lactide) Copolymers. Effects of Composition and Degradation

Drug transport to brain with targeted nanoparticles

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

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