Interfacial properties of amiodarone: the stabilizing effect of phosphate anions

Influence of environmental conditions on the interfacial organisation of fengycin, a bioactive lipopeptide produced by Bacillus subtilis

“…However, they accelerate the onset of the LE state of the fengycin monolayer (see A 0 - Table 1). This can be attributed to the larger size of the phosphate anions, which may induce steric effects in the interfacial film [23].…”

High throughput solubility measurement with automated polarized light microscopy analysis

“…The reason for this finding is not clear at present. Previously, it was suggested that amiodarone and phosphate anion in the buffer at pH 6.5 might interact to form an insoluble material 28…”

Interactions of bioactive molecules & nanomaterials with Langmuir monolayers as cell membrane models

“…Typical examples include: antimicrobials [117,, anti-tumorals [116,, antiinflammatory [77,[214][215][216][217], anesthesics [218][219][220][221][222][223][224][225][226][227], anti-psychotics [228][229][230][231][232][233][234][235][236][237], cardiac [238][239][240][241][242][243][244][245] and antihistaminic [246] drugs. To address this issue, Langmuir monolayers have been used involving AmB alone as well as mixed with membrane sterols.…”

“…The influence of subphase pH and ionic strength on monolayers stability was examined for cationic, amphiphilic drug -amiodaron -aiming at optimizing stable drug formulations [245]. Molecules of amiodaron can be soluble in water (in protonated form at acidic pH) or water-insoluble (in neutral form at basic pH).…”