Interfacial properties of morpholine-2,5-dione-based oligodepsipeptides and multiblock copolymers

Abstract

Abstract

Simple and Rapid Mechanochemical Synthesis of Lactide and 3S-(Isobutyl)morpholine-2,5-dione-Based Random Copolymers Using DBU and Thiourea

“…Polydepsipeptides (PDPs) are an increasingly attractive category of polyesteramides possessing alternating α-amino acid (AA) and α-hydroxyacid motifs and obtained via the ring-opening polymerization (ROP) of AA-derived morpholine-2,5-diones. − The ring-opening copolymerization (ROCP) of morpholine-2,5-diones with lactide (LA), glycolide, or ε-caprolactone permits the inclusion of peptide motifs and hydrogen bonds into those polyesters, enhancing their biocompatibility, degradability, and mechanical and thermal properties. ,− Furthermore, the possibility of selecting a specific AA as a starting material for these PDPs enables the incorporation of a particular hydrocarbon or functional group into the (co)­polymer, tuning the resulting material’s hydrophilic properties . Nevertheless, depending on the initial AA employed, some morpholine-2,5-diones display limited solubility in organic solvents.…”