Interfacing DNA with nanoparticles: Surface science and its applications in biosensing

He, Qunye; Wu, Qing; Feng, Xiangran; Liao, Ziyan; Peng, Wenyao; Liu, Yanfei; Peng, Dongming; Liu, Zhenbao; Mo, Miao

doi:10.1016/j.ijbiomac.2020.02.217

Cited by 52 publications

(29 citation statements)

References 176 publications

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“…Additionally, the detection performance and safety of MOF-based biosensing need to be further verified in vivo due to the complex in vivo environment, and the long-term biological toxicity of metal ion in MOF need to be further evaluated in vivo ( Chen et al, 2019 ), some biocompatible metal ions, such as Fe 2+ /Fe 3+ , Ni 3+ , Zr 4+ , Mn 2+ , Mg 2+ , Ca 2+ , Zn 2+ , or biomaterials, such as liposomal ( Dunne et al, 2019 ), bioconjugates ( Malfanti et al, 2019 ), and green synthetic routes should also be considered. The functional modification of MOFs with target ligands, such as aptamers ( Cai et al, 2018 ; He et al 2020a , 2020b ; Liu et al 2014a , 2015 ; Xiong et al, 2019 ) would endow the MOFs with more functionalities, with detection performances even better than the biosensor platforms based on graphene oxide ( Du et al, 2020 ; Liu et al, 2014b ).…”

Section: Discussion and Prospectivementioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Discussion and Prospectivementioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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“…2D materials, nanoparticles). [27][28][29] Here, we are reviewing all types of dimensional interfaces of the nanomaterials, except macroscopic interfaces (e.g. surfaceassemblies on microbeads and macro electrode surfaces), [30][31][32] with key developments in the biosensing applications of the DNA-materials interfaces since 2015.…”

Section: Introductionmentioning

confidence: 99%

DNA interfaces with dimensional materials for biomedical applications

et al. 2021

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“…Because of their substantially small size, nanomaterials may be formed by hundreds of millions of atoms [5]. Due to the high surface-to-volume ratio, the use of this type of carriers allows to deliver of small therapeutic biomolecules like DNA [6], RNA [7], proteins [8], drugs [9], and other molecules to a specific tumoral site. Nanoparticles can be functionalized with some recognition molecules, such as antibodies [10] or aptamers [11], that can target the nanoparticle into the cancerous cells, avoiding the endocytosis into healthy cells.…”

Section: Introductionmentioning

confidence: 99%

Target Nanoparticles Against Pancreatic Cancer: Fewer Side Effects in Therapy

Roacho-Pérez¹,

Garza-Treviño²,

Delgado-González³

et al. 2021

Preprint

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Pancreatic cancer leads the most common lethal tumor in America. This lethality is related to limited treatment options. Conventional treatments involve a non-specific use of chemotherapeutical agents like 5-FU, capecitabine, gemcitabine, cisplatine, oxaliplatine, or irinotecan, that produce several side effects. This review we focus on the use of targeted nanoparticles as an alternative to the standard treatment for the pancreatic cancer. The principal objective of the use of nanoparticles is the reduction in side effects that conventional treatments produce, mostly because of their nonspecificity. Currently, several molecular markets of pancreatic cancer cells have been studied to target nanoparticles and improve the actual treatment. Therefore, properly functionalizated nanoparticles with specific aptamers or antibodies can be used to recognize pancreatic cancer cells and once cancer is recognized, these nanoparticles can attack the tumor by drug delivery, hyperthermia, or gene therapy.

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Interfacing DNA with nanoparticles: Surface science and its applications in biosensing

Cited by 52 publications

References 176 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

DNA interfaces with dimensional materials for biomedical applications

Target Nanoparticles Against Pancreatic Cancer: Fewer Side Effects in Therapy

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