Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Liu, Juewen

doi:10.1021/acs.langmuir.6b00493

Cited by 94 publications

(126 citation statements)

References 77 publications

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“…Therefore, it is important to study its interaction with membranes. [19][20][21] The main components of the cell membrane are lipids with phosphocholine (PC) lipids being the most abundant on the outer membrane of eukaryotic cells. The interactions of PC membranes with various nanomaterials have been studied, [21][22][23][24][25][26] in particular, with various oxides.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21] The main components of the cell membrane are lipids with phosphocholine (PC) lipids being the most abundant on the outer membrane of eukaryotic cells. The interactions of PC membranes with various nanomaterials have been studied, [21][22][23][24][25][26] in particular, with various oxides. [27][28][29][30] A primary example is the spontaneous fusion of PC liposomes onto silica forming supported bilayers using van der Waals force.…”

Section: Introductionmentioning

confidence: 99%

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Adsorption of Nanoceria by Phosphocholine Liposomes

Liu

2016

Langmuir

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Nanoceria (CeO2 nanoparticle) possesses a number of enzyme-like activities. In particular, it scavenges reactive oxygen species (ROS) leading in vitro and in vivo anti-oxidation studies. An important aspect of fundamental physical understanding is its interaction with lipid membranes, the man component of the cell membrane. In this work, adsorption of nanoceria onto phosphocholine (PC) liposomes was performed. PC lipids are the main constituent of the cell outer membrane. Using fluorescence quenching assay, nanoceria adsorption isotherm was determined at various pH's and ionic strengths. A non-Langmuir isotherm occurred at pH 4.0 due to lateral electrostatic repulsion among adsorbed cationic nanoceria. The phosphate group in the PC lipid is mainly responsible for the interaction, and adsorbed nanoceria can be displaced by free inorganic phosphate. The tendency of the system to form large aggregates is a function of pH and the concentration of nanoceria, attributable to nanoceria being positively charged at pH 4 and neural at physiological pH. Calcein leakage test indicates that nanoceria induces liposome leakage due to transient lipid phase transition, and cryo-TEM indicates that the overall shape of the liposome is retained although deformation is still observed. This study provides fundamental biointerfacial information at a molecular level regarding the interaction of nanoceria and model cell membranes.3

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adsorption of Nanoceria by Phosphocholine Liposomes

Liu

2016

Langmuir

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“…This liposome composition was chosen to contain a mixture of two phosphatidylcholines (PCs). The first were phosphatidylcholine (PC from egg source) head groups leading to liposomes with neutral zeta potential which were heavily hydrated . The second had positively charged head groups.…”

Section: Methodsmentioning

confidence: 99%

“…The first were phosphatidylcholine (PC from egg source) head groups leading to liposomes with neutral zeta potential which were heavily hydrated. [32] The second had positively charged head groups. It was shown for ingesting other particles with this coating that positive charges from choline head in liposomes interacted with negative charges in cell membranes.…”

Section: Preparation Of Fnd-coated Liposomesmentioning

confidence: 99%

Cell Uptake of Lipid‐Coated Diamond

Morita

Martínez

Chipaux

et al. 2019

Part & Part Syst Charact

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Fluorescent nanodiamonds (FNDs) can be used as nanoscale magnetic resonance sensors and stable optical labels. As a first step for using FNDs as nanosensors inside cells, they have to be ingested. Several techniques that improve particle uptake have been used. A simple approach based on commercially available liposomes is used to improve uptake. Uptake into colon cancer cells (HT‐29 cells) is demonstrated. Additionally, it is shown for the first time that one can facilitate diamond uptake into yeast cells by removing the cell wall and creating a so‐called spheroplast. Finally, the characteristics of FNDs coated with lipids and their behavior inside the cells are evaluated.

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“…45,46 Most importantly, oxygen-containing groups on the surface of GO molecules may interact with hydroxyl groups of the BMP2 molecules through hydrogen bonding. 47,48 Third, the atomic layer framework of GO is of good mechanical strength, 49 which may provide mechanical support. At the molecular level, GO molecules are dispersed …”

mentioning

confidence: 99%

Continuous release of bone morphogenetic protein-2 through nano-graphene oxide-based delivery influences the activation of the NF-κB signal transduction pathway

Zhong¹,

Feng²,

Lin³

et al. 2017

IJN

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Graphene oxide (GO) has been used as a delivery vehicle for small molecule drugs and nucleotides. To further investigate GO as a smart biomaterial for the controlled release of cargo molecules, we hypothesized that GO may be an appropriate delivery vehicle because it releases bone morphogenetic protein 2 (BMP2). GO characterization indicated that the size distribution of the GO flakes ranged from 81.1 nm to 45,749.7 nm, with an approximate thickness of 2 nm. After BMP2 adsorption onto GO, Fourier-transformed infrared spectroscopy (FTIR) and thermal gravimetric analysis were performed. Compared to GO, BMP2-GO did not induce significant changes in the characteristics of the materials. GO continuously released BMP2 for at least 40 days. Bone marrow stem cells (BMSCs) and chondrocytes were treated with BMP2-GO in interleukin-1 media and assessed in terms of cell viability, flow cytometric characterization, and expression of particular mRNA. Compared to GO, BMP2-GO did not induce any significant changes in biocompatibility. We treated osteoarthritic rats with BMP2 and BMP2-GO, which showed significant differences in Osteoarthritis Research Society International (OARSI) scores ( P <0.05). Quantitative assessment revealed significant differences compared to that using BMP2 and BMP2-GO ( P <0.05). These findings indicate that GO may be potentially used to control the release of carrier materials. The combination of BMP2 and GO slowed the progression of NF-κB-activated degenerative changes in osteoarthritis. Therefore, we infer that our BMP2-GO strategy could alleviate the NF-κB pathway by inducing continuous BMP2 release.

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Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Abstract: ABSTRACT

Cited by 94 publications

References 77 publications

Adsorption of Nanoceria by Phosphocholine Liposomes

Adsorption of Nanoceria by Phosphocholine Liposomes

Cell Uptake of Lipid‐Coated Diamond

Continuous release of bone morphogenetic protein-2 through nano-graphene oxide-based delivery influences the activation of the NF-κB signal transduction pathway

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Interfacing Zwitterionic Liposomes with Inorganic Nanomaterials: Surface Forces, Membrane Integrity, and Applications

Abstract: ABSTRACT

Cited by 94 publications

References 77 publications

Adsorption of Nanoceria by Phosphocholine Liposomes

Adsorption of Nanoceria by Phosphocholine Liposomes

Cell Uptake of Lipid‐Coated Diamond

Continuous release of bone morphogenetic protein-2 through nano-graphene oxide-based delivery influences the activation of the NF-&kappa;B signal transduction pathway

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Product

Resources

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Continuous release of bone morphogenetic protein-2 through nano-graphene oxide-based delivery influences the activation of the NF-κB signal transduction pathway