Interfascicular Renal Cell Carcinoma Metastasis to the Ulnar Nerve

Humphries, Laura S.; Baluch, Daniel A.; Nystrom, Lukas M.; Borys, Dariusz; Bednar, Michael S.

doi:10.1177/1558944715627620

Cited by 4 publications

(1 citation statement)

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“…A case report by Grisold et al 15 demonstrated a mononeuropathy caused by intraneural metastasis from a carcinoid tumor. A separate case published by Humphries et al 16 demonstrated a patient with metastatic renal cell carcinoma to the ulnar nerve presenting as a painful mass in the right volar wrist. Another patient with a delayed sciatic nerve metastasis from a surgically removed renal cell carcinoma has been reported by Varin et al 17 Additionally, there is a rare instance of peripheral neuropathy brought on by infiltrative metastatic adenocarcinoma with no apparent primary lesion.…”

Section: Discussionmentioning

confidence: 99%

Melanoma metastasis to the femoral nerve: a novel case of melanoma masquerading as mononeuropathy. Illustrative case

Guerrero

Taghlabi

Meyer

et al. 2022

Journal of Neurosurgery: Case Lessons

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BACKGROUND Metastatic cancer may involve the central and peripheral nervous system, usually in the late stages of disease. At this point, most patients have been diagnosed and treated for widespread systemic disease. Rarely is the involvement of the peripheral nervous system the presenting manifestation of malignancy. One reason for this is a proposed “blood-nerve barrier” that renders the nerve sheath a relatively privileged site for metastases. OBSERVATIONS The authors presented a novel case of metastatic melanoma presenting as intractable leg pain and numbness. Further workup revealed concurrent disease in the brain and breast, prompting urgent treatment with radiation and targeted immunotherapy. LESSONS This case highlights the rare presentation of metastatic melanoma as a mononeuropathy. Although neurological complications of metastases tend to occur in later stages of disease after initial diagnosis and treatment, one must remember to consider malignancy in the initial differential diagnosis of mononeuropathy.

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Section: Discussionmentioning

confidence: 99%