This paper presents a context-aware decision making solution to the problem of radio resource management (RRM) and inter-cell interference coordination (ICIC) in long-term evolution-uplink (LTE-UL) system. The limitations of existing analytical, artificial intelligence (AI), and machine learning (ML) based approaches are highlighted and a novel integration of random neural network (RNN) based learning with genetic algorithm (GA) based reasoning is presented. Initially, three learning algorithms (gradient descent (GD), adaptive inertia weight particle swarm optimization (AIW-PSO), and differential evolution (DE)) are applied to RNN and two learning algorithms (GD and levenberg-marquardt (LM)) are applied to artificial neural network (ANN). In the second phase, the GA based reasoning is applied to the trained ANN and RNN models for performance optimization. Finally, the ANN and RNN based optimization results are compared with the state-of-the-art fractional power control (FPC) schemes in terms of user throughput and power consumption. The simulation results revealed that an RNN-DE based cognitive engine (CE) can provide up to 14% more cell capacity along with 6dBm and 9dBm less user power consumption as compared to RNN-GD and FPC methods respectively.