Interference effects within the kindling paradigm

The Effect of Low Frequency and Direct Current Stimulation on The Kindling Phenomenon in Rats

“…However, the decrease for the ETI 5 determination value (relative to ETI 4 ) was very great for most rats, rendering this explanation quite implausible. Thus, in the final analysis, the data obtained so far in our laboratory tend to indicate a high probability that an inhibitory process is set in motion by the 1-Hz stimulation (Gaito, 1980d). In contrast to the relatively permanent process produced during the 60-Hz stimulation (Goddard et al, 1969;Racine, 1978), this one appears to be transient, dissipating slowly over time and similar to the "after effect" reported by Mclntyre and Goddard (1973).…”

Repeated Ethanol Withdrawal Delays Development of Focal Seizures in Hippocampal Kindling

“…A number of experimental manipulations have been shown to inhibit the development of electrical kindling (Dragunow, 1986;Gaito, 1980;Shao and Valenstein, 1982). Burchfiel and others (Burchfiel and Applegate, 1989;Burchfiel et al, 1982;Duchowny and Burchfiel, 1981), for example, have reported that alternately stimulating multiple brain sites results in the normal development of kindling at one, primary brain site, but suppression at other sites.…”

The suppression of kindling with low-frequency brain stimulation: Statistical data with duration variable

“…In a series of experiments, it was found that I-Hz or 3-Hz sine wave stimulation before and after a 60-Hz stimulation trial suppressed the tendency of the 6O-Hzcurrent to produce kindling behavior (Gaito, 1979a(Gaito, , 1979b(Gaito, , 1980a(Gaito, , 1980b(Gaito, , 1980c(Gaito, , 1980dGaito, Nobrega, & Gaito, 1980) . The experiments with 3-Hz stimulation were conducted at an intertrial interval of 1 h between the imposition of the 3-Hz and 60-Hz stimulation trials.…”