Interference of aluminium on iron metabolism in erythroleukaemia K562 cells

Intracellular Changes of Metal Elements by Fucoidan Extracted from Brown Seaweed (Cladosiphon okamuranus)

“…Taking together the present and previous findings, it is conceivable that fucoidan-binding Al may move into the S-phase nucleus. A number of studies of a variety of cultured cell lines have shown that Al loading resulted in abnormal Fe accumulation and compartmentalization [31][32][33]. Co-localization of Al and Fe has been found in hepatocytes of dialysis patients [34].…”

Pseudomonas fluorescens orchestrates a fine metabolic‐balancing act to counter aluminium toxicity

“…As Al and Fe share numerous common physicochemical features, it is not surprising that Fe metabolism is severely affected during Al stress (Morgan and Redgrave, 1998). Al is known to impede proteins/enzymes that are dependent on Fe to function in an effective manner due to their similar trivalent state; Al can readily substitute for Fe especially in environments where the former is easily accessible (Perez et al, 1999). However, its inability to undergo any redox manipulation compels Al to be associated with these essential biomolecules; hence, rendering them ineffective (Zatta et al, 2003;Middaugh et al, 2005).…”

Engineering aluminum binding affinity in an isolated EF-hand from troponin C: A computational site-directed mutagenesis study

“…The dissociation constants for transferrin binding to iron and aluminum are within the same order of magnitude: 1.75 · 10 À9 M À1 and 1.37 · 10 À9 M À1 , respectively [49]. Cells cultured in the presence of Al 3+ were found to have an increased number of tranferrin receptors, so Fe 3+ uptake values were not altered [49]. In fluids where the concentrations of transferrin and citrate are low, Al 3+ binds nucleoside di-and triphosphates, and is found to displace Mg 2+ from the nucleotides [6].…”

“…About 90% of the Al 3+ in the blood is bound by the iron-transport protein transferrin [6,48]. The dissociation constants for transferrin binding to iron and aluminum are within the same order of magnitude: 1.75 · 10 À9 M À1 and 1.37 · 10 À9 M À1 , respectively [49]. Cells cultured in the presence of Al 3+ were found to have an increased number of tranferrin receptors, so Fe 3+ uptake values were not altered [49].…”