Interference of Gadolinium-Containing Contrast-Enhancing Agents With Colorimetric Calcium Laboratory Testing

Löwe, Andrea; Balzer, Thomas; Hirt, Uta

doi:10.1097/01.rli.0000170447.45577.5e

Cited by 25 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lack of an effect of gadoxetate disodium, gadoterate meglumine, and gadobutrol on the calcium assays is supported by others, as analytical interference in calcium assays has been attributed to the reduced complex stability and excess ligand in the formulation of the nonionic linear GdCAs [ 8 , 9 , 11 , 15 ]. Evidence points to the fact that gadopentetate dimeglumine, gadoterate, gadoteridol, gadobutrol, gadobenate dimeglumine, and gadoxetate disodium do not cause analytical interference in colorimetric calcium assays, regardless of which colorimetric technique was used [ 2 , 6 – 9 , 11 – 13 ].…”

Section: Discussionmentioning

confidence: 92%

“…Evidence points to the fact that gadopentetate dimeglumine, gadoterate, gadoteridol, gadobutrol, gadobenate dimeglumine, and gadoxetate disodium do not cause analytical interference in colorimetric calcium assays, regardless of which colorimetric technique was used [ 2 , 6 – 9 , 11 – 13 ]. Only nonionic linear GdCAs are relevant when considering Gd chelate binding as a mechanism in the analytical interference by CAs in laboratory blood tests [ 2 – 4 , 6 – 8 , 11 – 13 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analytical Interference by Contrast Agents in Biochemical Assays

Otnes

Fogh‐Andersen

Rømsing

et al. 2017

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

Objective To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0.5 mM and 12 mg iodine/mL, respectively. Subsequently, 12 assays were reexamined using 1/2 and 1/4 of these CA concentrations. The results were assessed statistically by a paired Student's t-test. Results Iodixanol produced a negative interference on the bicarbonate (p = 0.011), lactate dehydrogenase (p < 0.0001), and zinc (p = 0.0034) assays and a positive interference on the albumin (p = 0.0062), calcium (p < 0.0001), ionized calcium (p = 0.0086), iron (p < 0.0001), and potassium (p = 0.0003) assays. Iomeprol produced a negative interference on the bicarbonate (p = 0.0057) and magnesium (p = 0.0001) assays and a positive interference on the calcium (p < 0.0001) and potassium (p = 0.0012) assays. Gadoxetate disodium produced a negative interference on the iron (p < 0.0001) and zinc (p < 0.0001) assays and a positive interference on the sodium (p = 0.032) assay. Conclusion CAs cause analytical interference. Attention should be given to the above-mentioned analyte-CA combinations when assessing laboratory blood test results obtained after CA administration.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Analytical Interference by Contrast Agents in Biochemical Assays

Otnes

Fogh‐Andersen

Rømsing

et al. 2017

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

show abstract

“…Macro minerals; sodium (Na), potassium (K), magnesium (Mg), phosphorus (P), chlorine (Cl), calcium (Ca), and micro minerals; iron (Fe), copper (Cu), and lithium (Li) will be determined using the following methods in Olympus AU 400 auto analyser and Electrolyte Analyser/ AVL machine by an appointed medical laboratory service provider (Duffy 1982 ; Khalil et al 1986 ; Burnett et al 2000 ; Löwe et al 2005 ) (Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins

Dissanayake,

Herath,

Opatha

et al. 2024

Behav Genet

View full text Add to dashboard Cite

Nutrition and diet are key modifiable risk factors for the rising burden of non-communicable diseases like cardio-vascular diseases and diabetes in low- and middle- income countries (LMICs). The nutritional transition in dietary behaviours in LMICs has most likely contributed to this problem. Although traditionally assumed to be environmental, dietary choices are also genetically influenced. Twin study designs can be used to investigate the relative influence of genes and environment on nutrition intake, eating behaviours and associated psychological health. The overall aim of this project is to: provide proof-of-concept for the feasibility of using dietary (biomarker) data within the Children-of-Twin design in nutrition studies, develop laboratory skills and statistical genetic skills and establish a Sri Lankan-specific food composition database. Currently, a pilot study is being conducted with 304 individuals (38 Monozygotic twin pairs, 38 Dizygotic twin pairs and their male or female adult offspring). Questionnaire data on nutritional intake, eating behaviours, psychological well-being, physical health, and bio-specimens are being collected. A Sri Lankan-specific food composition database was developed, training sessions on macro and micro element analysis in biological samples and statistical genetics skills development were conducted and Community Engagement and Involvement programs were carried out in two districts of Sri Lanka.

show abstract

“…(39) investigated the interference of gadodiamide, gadoversetamide, gadopentetate, dimeglumine, and gadoteridol on several calcium assays, and found that gadolinium contrast agents caused no interference on two arsenazo assays, one inductively coupled plasma mass spectrometry (ICP-MS) technique, one ion selective electrode assay and one ionized calcium method, whereas a negative bias was observed with three OCP methods (between −9 and −24% for gadodiamide and between −9 and −22% for gadoversetamide, respectively). Löwe et al (40) also evaluated the interference of commercially available gadolinium-containing contrast-enhancing agents with calcium measured with either an arsenazo-based colorimetric method or an OCP assay. Although gadopentetate and gadobenate did not significantly altered the concentration of calcium measured with either method, the presence of gadodiamide and gadoverset-amide caused a positive bias with arsenazo-based colorimetry and a negative one with the OCP assay.…”

Section: Analytical Interferencementioning

confidence: 99%

Interference of medical contrast media on laboratory testing

Lippi

Daves

Mattiuzzi³

2014

Biochem Med

View full text Add to dashboard Cite

The use of contrast media such as organic iodine molecules and gadolinium contrast agents is commonplace in diagnostic imaging. Although there is widespread perception that side effects and drug interactions may be the leading problems caused by these compounds, various degrees of interference with some laboratory tests have been clearly demonstrated. Overall, the described interference for iodinate contrast media include inappropriate gel barrier formation in blood tubes, the appearance of abnormal peaks in capillary zone electrophoresis of serum proteins, and a positive bias in assessment of cardiac troponin I with one immunoassay. The interference for gadolinium contrast agents include negative bias in calcium assessment with ortho-cresolphthalein colorimetric assays and occasional positive bias using some Arsenazo reagents, negative bias in measurement of angiotensin converting enzyme (ACE) and zinc (colorimetric assay), as well as positive bias in creatinine (Jaffe reaction), total iron binding capacity (TIBC, ferrozine method), magnesium (calmagite reagent) and selenium (mass spectrometry) measurement. Interference has also been reported in assessment of serum indices, pulse oximetry and methaemoglobin in samples of patients receiving Patent Blue V. Under several circumstances the interference was absent from manufacturer-supplied information and limited to certain type of reagents and/or analytes, so that local verification may be advisable to establish whether or not the test in use may be biased. Since the elimination half-life of these compounds is typically lower than 2 h, blood collection after this period may be a safer alternative in patients who have received contrast media for diagnostic purposes.

show abstract

Interference of Gadolinium-Containing Contrast-Enhancing Agents With Colorimetric Calcium Laboratory Testing

Abstract: The study demonstrates that gadopentetate dimeglumine and gadobenate dimeglumine generate no interference with colorimetric methods for calcium determination, whereas strong interference was shown for gadodiamide and gadoversetamide under clinically relevant conditions.

Cited by 25 publications

References 17 publications

Analytical Interference by Contrast Agents in Biochemical Assays

Analytical Interference by Contrast Agents in Biochemical Assays

The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins

Interference of medical contrast media on laboratory testing

Contact Info

Product

Resources

About