A wide range of mass gain in the inland of the Tibetan Plateau (TP) has been observed by the Gravity Recovery and Climate Experiment (GRACE). But there are still controversies on how to understand this phenomenon. In this paper, satellite geodesy data and hydrological models are combined and applied for extracting signals caused by tectonic processes in the TP during the period from 2003 to 2009. We find that in the inland of the TP there are three regions with a significant signal that should be attributed to tectonic processes. The three prominent mass signals, each located in the western, central, and eastern TP, are estimated to be at the rate of 1.47 ± 0.43, −0.85 ± 0.53, and 1.51 ± 0.56 cm/year, respectively, in equivalent water height. However, the rate caused by Earth surface deformation constrained by GPS is 0.33 ± 0.15/0.30 ± 0.10/0.14 ± 0.24 cm/year in equivalent water height, which cannot explain the whole tectonic signals and indicates that a significant mass change occurs beneath the crust, that is, the deformation of the Moho interface. We estimate the Moho change rate in the inland of the TP and find that the Moho interface is suffering an uneven deformation. The Moho is uprising at a rate of 18.1 ± 7.2 mm/year in the west and 21.7 ± 9.7 mm/year in the east of the TP, while there is an obvious deepening rate of −18.3 ± 8.6 mm/year in the central TP.