Interference Phenomena in Roentgen Rays

Friedrich, Wolfgang; Knipping, P.; Laue, Μ. v.

doi:10.4159/harvard.9780674366701.c29

Cited by 1 publication

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“…This situation was remedied, radically, with the discovery in 1912 by Max von Laue of X-ray diffraction from crystals. [12] This landmark discovery was immediately taken advantage of, particularly by W. H. Bragg and W. L. Bragg, father and son, as the starting point of crystal Leslie Leiserowitz, and their joint work on the assignment of the absolute configuration of chiral molecules as described in this manuscript has been awarded by the Prelog Medal of the ETH Zurich. After retirement Meir's scientific interest centers on the understanding of chemical properties of pyroelectric and piezoelectric crystals and on particular, the mechanism of electro-freezing of supercooled water at the molecular level.…”

Section: The Assignment Of Molecular Chiralitymentioning

confidence: 95%

“…In hindsight, it is remarkable that information on the molecular stereochemistry in those times could be gleaned by such indirect methods. This situation was remedied, radically, with the discovery in 1912 by Max von Laue of X‐ray diffraction from crystals [12] . This landmark discovery was immediately taken advantage of, particularly by W. H. Bragg and W. L. Bragg , father and son, as the starting point of crystal structure elucidation and the revealing of molecular structure [13]…”

Section: The Assignment Of Molecular Chiralitymentioning

confidence: 99%

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The Story Behind the Link between Molecular Chirality and Crystal Shape

Lahav

Leiserowitz

2023

Helvetica Chimica Acta

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Here we describe the story behind the link between molecular chirality and macroscopic phenomena, the latter being a probe for the direct assignment of absolute configuration of chiral molecules. First, a brief tour of the history of molecular stereochemistry, starting with the classic experiment reported by Pasteur in 1848 on the separation of enantiomorphous crystals of a salt of tartaric acid, and his conclusion that the molecules of life are chiral of single‐handedness. With time, this study raised, inter alia, two fundamental questions: the absolute configuration of chiral molecules and how a molecule of given configuration shapes the enantiomorphous morphology of its crystal. As for the first question, following the beginning of crystal structure determination by X‐ray diffraction in 1912, it took almost 40 years before Bijvoet assigned molecular chirality through the esoteric method involving anomalous X‐ray scattering. We have been able to address and link both questions through ‘everyday concepts of left and right’ (in the words of Jack Dunitz) by the use of ‘tailor‐made’ auxiliaries. By such means, it proved possible to reveal, through morphology, etch patterns, epitaxy and symmetry reduction of both chiral and, paradoxically, centrosymmetric crystals, the basic chiral symmetry of the molecules of life, the α‐amino acids and sugars.

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Section: The Assignment Of Molecular Chiralitymentioning

confidence: 95%

Section: The Assignment Of Molecular Chiralitymentioning

confidence: 99%