Interference Potential of Personal Lubricants and Vaginal Medications on ThinPrep(R) Pap Tests

Feit, Tim D.; Mowry, Debra A.

doi:10.3122/jabfm.2011.02.100086

Cited by 12 publications

(13 citation statements)

References 24 publications

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“…However, all of them lack either a control group or randomization. Feit and Mowry [18] reported that lubricants containing ''carbomers'' or ''carbopol polymers'' may interfere with Thinprep (Hologic Inc., Bedford, MA) evaluation of Pap tests because they seem to lead to significant reduction in sample cellularity. However, a corresponding unsatisfactory result was found in their control group, which was evaluated as normal in its matched-control lubricant specimen.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vaginal Lubrication on Unsatisfactory Results of Cervical Smears

Pergialiotis

Vlachos

Rodolakis

et al. 2015

Journal of Lower Genital Tract Disease

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Section: Discussionmentioning

confidence: 99%

The Effect of Vaginal Lubrication on Unsatisfactory Results of Cervical Smears

Pergialiotis

Vlachos

Rodolakis

et al. 2015

Journal of Lower Genital Tract Disease

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“…9 -12,18 It was reported that certain lubricants containing carbopol polymers can interfere with the ThinPrep filter during processing. 12 In most of these studies, lubricant gel either was added intentionally to LBC specimens or directly contaminated the cervix. Most of these study designs do not reflect actual clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Association of Speculum Lubrication with Pain and Papanicolaou Test Accuracy

Uygur

Güler

Yaycı

et al. 2012

The Journal of the American Board of Family Medicine

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Purpose: To determine the effects of lubrication of the vaginal speculum before insertion during a Papanicolaou test on perceived pain and quality of the cytology specimen.Methods: Four hundred eligible women participating in cervical cancer screening and an early detection program were randomized with respect to lubricant gel use before speculum insertion. Perceived pain during speculum insertion and cytology results were assessed in study groups.Results: The mean age of the patients was 45.7 years (range, 23-77 years). Pain score of the NO GEL group was significantly higher than that of the GEL group (2.3 and 1.6, respectively; P < .05).

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“…For example, Holton et al found decreased cellularity when the ThinPrep solution was contaminated with K‐Y Jelly after specimen collection . In contrast, Feit and Mowry found that there was no effect on cellularity of the specimen when the ThinPrep solution was contaminated with K‐Y Jelly after specimen collection . Despite these conflicting studies, the manufacturer of ThinPrep includes K‐Y Jelly on its list of approved lubricants…”

Section: Discussionmentioning

confidence: 99%

Does speculum lubricant affect liquid‐based Papanicolaou test adequacy?

Lin

Taylor

Alperstein

et al. 2013

Cancer Cytopathology

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BACKGROUND:There is a paucity of data on the effect of vaginal lubricants on specimen adequacy in the era of liquidbased Papanicolaou (Pap) tests. Current manufacturer recommendations advise against the use of lubricants, especially those that contain carbomers or carbopol polymers. There is, however, no conclusive evidence to support this recommendation. Moreover, the data that does exist is conflicting. METHODS: Retrospective review was performed of all liquidbased Pap tests collected between January 2010 and March 2012 by the Gynecologic Oncology division at a single hospital. Specimen adequacy was compared for vaginal and cervical specimens that were collected with and without a lubricant. Results were also compared for specimens collected with lubricants that did or did not contain carbomers. RESULTS:There was no significant difference in specimen adequacy for cervical or vaginal Pap test specimens collected with a water-soluble lubricant not containing carbomers, compared to those collected without a lubricant. There was, however, a significantly higher rate of insufficient specimens when a water-soluble lubricant containing carbomers was

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Interference Potential of Personal Lubricants and Vaginal Medications on ThinPrep(R) Pap Tests

Cited by 12 publications

References 24 publications

The Effect of Vaginal Lubrication on Unsatisfactory Results of Cervical Smears

The Effect of Vaginal Lubrication on Unsatisfactory Results of Cervical Smears

Association of Speculum Lubrication with Pain and Papanicolaou Test Accuracy

Does speculum lubricant affect liquid‐based Papanicolaou test adequacy?

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