Interference with gesture production by theta burst stimulation over left inferior frontal cortex

Bohlhalter, Stephan; Vanbellingen, Tim; Bertschi, Manuel; Wurtz, Pascal; Cazzoli, Dario; Nyffeler, Thomas; Heß, Christian; Müri, René M.

doi:10.1016/j.clinph.2010.11.008

Cited by 34 publications

(27 citation statements)

References 49 publications

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“…We extend these results by showing that the computations of this region reflect visual information during the common use task, suggesting that an important dimension for this biasing process is the visual form of the object. There are consequences of this relationship as well, as damage to the inferior frontal gyrus will result in impaired pantomime (see Bohlhalter et al, 2011) and deficits in both producing and recognizing tool-related actions (Tarhan et al, 2015). …”

Section: Resultsmentioning

confidence: 99%

Differential Tuning of Ventral and Dorsal Streams during the Generation of Common and Uncommon Tool Uses

Matheson

Buxbaum

Thompson-Schill

2017

Journal of Cognitive Neuroscience

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Our use of tools is situated in different contexts. Prior evidence suggests that diverse regions within the ventral and dorsal streams represent information supporting common tool use. However, given the flexibility of object concepts, these regions may be tuned to different types of information when generating novel or uncommon uses of tools. To investigate this, we collected fMRI data from participants who reported common or uncommon tool uses in response to visually presented familiar objects. We performed a pattern dissimilarity analysis in which we correlated cortical patterns with behavioral measures of visual, action, and category information. The results showed that evoked cortical patterns within the dorsal tool use network reflected action and visual information to a greater extent in the uncommon use group, whereas evoked neural patterns within the ventral tool use network reflected categorical information more strongly in the common use group. These results reveal the flexibility of cortical representations of tool use and the situated nature of cortical representations more generally.

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Section: Resultsmentioning

confidence: 99%

Differential Tuning of Ventral and Dorsal Streams during the Generation of Common and Uncommon Tool Uses

Matheson

Buxbaum

Thompson-Schill

2017

Journal of Cognitive Neuroscience

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“…The current results accurately matched those of these previous studies. Theta burst stimulation to the left IFG also reportedly significantly lowered the score for the TULIA (98). Furthermore, previous studies have also revealed that theta burst stimulation to the left IPL significantly reduced the imitation score in the TULIA, regardless of being meaningful or meaningless gestures (99).…”

Section: Discussionmentioning

confidence: 98%

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

et al. 2018

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Limb apraxia is a higher brain dysfunction that typically occurs after left hemispheric stroke and its cause cannot be explained by sensory disturbance or motor paralysis. The comparison of motor signals and visual feedback to generate errors, i.e., visuo-motor integration, is important in motor control and motor learning, which may be impaired in apraxia. However, in apraxia after stroke, it is unknown whether there is a specific deficit in visuo-motor temporal integration compared to visuo-tactile and visuo-proprioceptive temporal integration. We examined the precision of visuo-motor temporal integration and sensory-sensory (visuo-tactile and visuo-proprioception) temporal integration in apraxia after stroke by using a delayed visual feedback detection task with three different conditions (tactile, passive movement, and active movement). The delay detection threshold and the probability curve for delay detection obtained in this task were quantitative indicators of the respective temporal integration functions. In addition, we performed subtraction and voxel-based lesion-symptom mapping to identify the brain lesions responsible for apraxia and deficits in visuo-motor temporal integration. The behavioral experiments showed that the delay detection threshold was extended and that the probability curve for delay detection was less steep in apraxic patients compared to controls (pseudo-apraxic patients and unaffected patients), only for the active movement condition, and not for the tactile and passive movement conditions. Furthermore, the severity of apraxia was significantly correlated with the delay detection threshold and the steepness of the probability curve in the active movement condition. These results indicated that multisensory (i.e., visual, tactile, and proprioception) feedback was normally temporally integrated, but motor prediction and visual feedback were not correctly temporally integrated in apraxic patients. That is, apraxic patients had difficulties with visuo-motor temporal integration. Lesion analyses revealed that both apraxia and the distortion of visuo-motor temporal integration were associated with lesions in the fronto-parietal motor network, including the left inferior parietal lobule and left inferior frontal gyrus. We suppose that damage to the left inferior fronto-parietal network could cause deficits in motor prediction for visuo-motor temporal integration, but not for sensory-sensory (visuo-tactile and visuo-proprioception) temporal integration, leading to the distortion of visuo-motor temporal integration in patients with apraxia.

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“…Double-pulse stimulation over the parietal operculum interferes with the tendency towards automatic imitation of the gestures that a subject observes, that is the affordance (Mengotti et al, 2013). And theta burst stimulation over Broca’s area interferes with the production of gestures themselves (Bohlhalter et al, 2011). These results are consistent with the interpretation we have given for our imaging results.…”

Section: Discussionmentioning

confidence: 99%

Using action understanding to understand the left inferior parietal cortex in the human brain

et al. 2014

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In an fMRI study we tried to establish whether the areas in the human brain that are involved in the understanding of actions are homologous with the inferior parietal cortex (area PFG) in macaque monkeys. Cells have been described in area PFG that discharge differentially depending upon whether the observer sees food being brought to the mouth or a small object being put in a container. In our study the observers saw videos in which the use of different objects was demonstrated in pantomime; and after viewing the videos, the subject had to pick the object that was appropriate to the pantomime. We found a cluster of activated voxels in parietal areas PFop and PFt and this cluster was greater in the left hemisphere than in the right. We suggest a mechanism that could account for this asymmetry, relate our results to handedness and suggest that they shed light on the human syndrome of apraxia. Finally, we suggest that during the evolution of the hominids, this same pantomime mechanism could have been used to ‘name’ or request objects.

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Interference with gesture production by theta burst stimulation over left inferior frontal cortex

Cited by 34 publications

References 49 publications

Differential Tuning of Ventral and Dorsal Streams during the Generation of Common and Uncommon Tool Uses

Differential Tuning of Ventral and Dorsal Streams during the Generation of Common and Uncommon Tool Uses

Distortion of Visuo-Motor Temporal Integration in Apraxia: Evidence From Delayed Visual Feedback Detection Tasks and Voxel-Based Lesion-Symptom Mapping

Using action understanding to understand the left inferior parietal cortex in the human brain

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