Interferences With CGM Systems: Practical Relevance?

Drug interference with biochemical laboratory tests

“…Other clinically important DLTIs comprise those induced by contrast media (proteinemia, bilirubin, creatinine, iron, calcium, coagulation factors); by proton-pump inhibitors (higher serum concentrations of chromogranin A) and acetaminophen interference with continuous glucose monitor (CGM) sensing, which results in erroneously high readings ( 29 ). Several CGM devices are designed to eliminate interference from acetaminophen, but there is still important interference from ascorbic acid and antineoplastic drug, hydroxyurea ( 30 ).…”

Laboratory Protocol and Pilot Results for Dynamic Interference Testing of Continuous Glucose Monitoring Sensors

“…[8][9][10][11] At the same time, the manufacturers and the users need to understand the relevance of a potential interferent to draw correct conclusions about clinical or regulatory consequences (eg, warnings in the instructions for use). 16 In addition, there is no information existing in the literature at all about a potential interaction of dynamic changes of several potentially interfering substances when taken in parallel on CGM performance. However, this is clinical reality, for example, when patients take multiple drugs in the morning prior to breakfast and sometimes in conjunction with multiple nutritional supplements.…”

“… 8 - 11 At the same time, the manufacturers and the users need to understand the relevance of a potential interferent to draw correct conclusions about clinical or regulatory consequences (eg, warnings in the instructions for use). 16 …”

Alternative Site of Real-Time Continuous Glucose Monitoring Sensor Application for Abdominal Surgery in the Infraclavicular Region

“…Vasopressors and mechanical support, interfering medication, rapid changes in electrolytes and acid-base balance, coagulation disorders, even patient sedation and possible sensor compression may affect the interstitial glucose measurement. [3][4][5] We tested 14 patients undergoing major abdominal surgery (86% male, liver transplantation n = 6, pancreas resection n = 7 and abdominal aortic repair n = 1). Dexcom G6 sensor (Dexcom, Inc., San Diego, CA, USA) paired with an iPhone or Dexcom receiver was applied perioperatively, and calibration was performed every 6 hours on day 1, then once daily.…”

“…Vasopressors and mechanical support, interfering medication, rapid changes in electrolytes and acid-base balance, coagulation disorders, even patient sedation and possible sensor compression may affect the interstitial glucose measurement. 3-5…”