Interferometric biosensor based on planar optical waveguide sensor chips for label-free detection of surface bound bioreactions

Schmitt, Katrin; Schirmer, Bernd; Hoffmann, Christian; Brandenburg, Albrecht; Meyrueis, Patrick

doi:10.1016/j.bios.2006.10.016

Cited by 174 publications

(101 citation statements)

References 20 publications

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“…Optical interferometers have already used in detection of surface bound bio-reactants such as bacteria, spores, toxins, viruses, and proteins (Schneider et al, 2000;Schmitt et al, 2007). These devices are based on evanescent field sensing.…”

Section: Interferometer-based Biosensorsmentioning

confidence: 99%

Nanodiagnostics: a new frontier for veterinary and medical sciences

Lambe¹,

Minakshi²,

Brar³

et al. 2016

JEBAS

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Infectious diseases are one of the greatest threats to animal and human population living in the developing world. These diseases have capacity to instigate in a small area and then open out very fast to the rest of the world and causing a heavy pandemic situation, for example; avian influenza pandemic. Such diseases infect large masses of population and may lead to loss of lives and also incur huge economic losses. Therefore, the best way to control these diseases is by diagnosing it at a very primary level and taking necessary precautionary measures so as to avoid the spread. Since last few years, the diagnostic approach has changed from tedious molecular biological techniques, to easy and rapid diagnostic techniques. Nanotechnology has extended the molecular diagnostics limit to nanoscale. These developed techniques do not require sophisticated laboratories and expert personnel, and hence are a cheap diagnostic approach. These assays can also be performed at the field level where the patient is present and get the results there itself. Hence, they are also called as pen side test or lab on chip diagnostic assays. The biological tests using nanotechnology become quicker, more flexible and more sensitive. These techniques have greatly influenced the diagnostic approach in the veterinary as well as medical field. Especially in the developing countries such as India, where the laboratory services are not

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Section: Interferometer-based Biosensorsmentioning

confidence: 99%

Nanodiagnostics: a new frontier for veterinary and medical sciences

Lambe¹,

Minakshi²,

Brar³

et al. 2016

JEBAS

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“…The application of these devices in the biosensors field (Schmitt et al, 2007;Schwartz et al, 2006) is a rapidly developing field due to the possibility of the implementation of real time measurements without the need for more complex and indirect procedures (Marques et al, 2009). A prototype device for refractive index measurement with high sensitivity and high dynamic range based on a Mach-Zehnder integrated interferometer was developed, Fig.…”

Section: Integrated Refractive Index Sensor Based On a Mach-zehnder Imentioning

confidence: 99%

Fabrication of Planar Integrated Optic Devices by Laser Patterning

Marques¹,

Alexandre²,

Ghasemphour³

et al. 2011

Rapid Prototyping Technology - Principles and Functional Requirements

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“…Examples of IO sensors are grating couplers [1], resonant optical microcavity sensors [2][3][4], photonic crystal waveguide sensors [5,6] and interferometric sensors [7][8][9][10][11]. Interferometric biosensors use the evanescent field to detect refractive index (RI) changes induced by analyte binding.…”

Section: Introductionmentioning

confidence: 99%

“…Interferometric biosensors use the evanescent field to detect refractive index (RI) changes induced by analyte binding. Extremely high RI sensitivities (~10 −8 refractive index units (RIU)) are reported with interferometric sensors like the Mach-Zehnder interferometer [11] and the Young interferometer (YI) [9,10]. However, it is often not possible to fully use the high sensitivity capabilities of the sensor, because any RI change within the evanescent field will contribute to the measured signal.…”

Section: Introductionmentioning

confidence: 99%

Size-selective analyte detection with a Young interferometer sensor using multiple wavelengths

Mulder¹,

Blum²,

Subramaniam³

et al. 2016

Opt. Express

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We present a method to discriminate between analytes based on their size using multiple wavelengths in a Young interferometer. We measured the response of two wavelengths when adding 85 nm beads (representing specific binding), protein A (representing non-specific binding) and D-glucose (inducing a bulk change) to our sensor. Next, the measurements are analysed using a approach based on theoretical analysis, and a ratio-based analysis approach to discriminate between bulk changes and the binding of the different sized substances. Moreover, we were able to discriminate binding of 85 nm beads from binding of protein A (~2 nm) in a blind experiment using the ratio-based approach. This can for example be used to discriminate specific analyte binding of larger particles from nonspecific binding of smaller particles. Therefore, we believe that by adding size-selectivity we can strongly improve the performance of the Young interferometer sensor and integrated optical interferometric sensors in general. 6396-6405 (2000). 8. C. Stamm, R. Dangel, and W. Lukosz, "Biosensing with the integrated-optical difference interferometer: dualwavelength operation," Opt. Commun. 153(4-6), 347-359 (1998). 9. K. Schmitt, B. Schirmer, C. Hoffmann, A. Brandenburg, and P. Meyrueis, "Interferometric biosensor based on planar optical waveguide sensor chips for label-free detection of surface bound bioreactions," Biosens.

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Interferometric biosensor based on planar optical waveguide sensor chips for label-free detection of surface bound bioreactions

Cited by 174 publications

References 20 publications

Nanodiagnostics: a new frontier for veterinary and medical sciences

Nanodiagnostics: a new frontier for veterinary and medical sciences

Fabrication of Planar Integrated Optic Devices by Laser Patterning

Size-selective analyte detection with a Young interferometer sensor using multiple wavelengths

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