Glass microspheres have been used in laser physics as hydrogen microcontainers over a period of more than fifty years. However, developers of glass compositions are guided in their work only by practical experience and intuition in view of the lack of reliable data on the influence of glass components on the hydrogen permeability. There is only one expression that approximately describes the dependence of the permeability on the composition, i.e., the SiO 2 , B 2 O 3 , and P 2 O 5 contents. It is advisable to complement the computational equation by the Ermolenko structure connectivity factor in order to include all glass components and the network dimensionality in the calculations.