Stern-Gerlach and/or matter-wave interferometry has garnered significant interest amongst members of the scientific community over the past few decades. Early theoretical results by Schwinger et al. demonstrate the fantastic precision capabilities required to realize a full-loop Stern-Gerlach interferometer, i.e., a Stern-Gerlach setup that houses the capability of recombining the split wave-packets in both, position and momentum space over a certain characteristic interferometric time. Over the years, several proposals have been put forward that seek to use Stern-Gerlach and/or matter-wave interferometry as a tool for a myriad of applications of general interest, some of which include tests for fundamental physics (viz., quantum wave-function collapse, stringent tests for the Einstein equivalence principle at the quantum scale, breaking the Standard Quantum Limit (SQL) barrier, and so forth), precision sensing, quantum metrology, gravitational wave detection and inertial navigation. In addition, a large volume of work in the existing literature has been dedicated to the possibility of using matter-wave interferometry for tests of quantum gravity. Inspired by the developments in this timely research field, this Perspective attempts to provide a general overview of the theory involved, the challenges that are yet to be addressed and a brief outlook on what lays ahead.