Interferometry in the Evaluation of Precorneal Tear Film Thickness in Dry Eye

Hosaka, Eri; Kawamorita, Takushi; Ogasawara, Yūko; Nakayama, N.; Uozato, Hiroshi; Shimizu, Kimiya; Doğru, Murat; Tsubota, Kazuo; Goto, Eiki

doi:10.1016/j.ajo.2010.07.019

Cited by 83 publications

(49 citation statements)

References 25 publications

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“…First, the CET data of the OCT system include the precorneal tear film, the thickness of which has been reported to be between 2 and 7 lm [38][39][40]. This is an apparent limitation of OCT measurements and a source of possible uncertainty in our results.…”

Section: Discussionmentioning

confidence: 97%

Age-related differences in corneal epithelial thickness measurements with anterior segment optical coherence tomography

2016

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Section: Discussionmentioning

confidence: 97%

Age-related differences in corneal epithelial thickness measurements with anterior segment optical coherence tomography

2016

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“…2,3 Ocular surface temperature is mainly affected by tear film stability 4,5 and the tear film instability is one of the major causes of dry eye symptoms. 6,7 Studies have observed that the dry eye group renders a greater temperature decrease in the OST than the control group; 8,9 the greater rate of cooling in the dry eye group is the direct result of excessive tear evaporation. 10 In a later study, an opposite finding was reported that dry eye patients had a smaller temperature decrease in the OST.…”

Section: Introductionmentioning

confidence: 99%

Noncontact detection of dry eye using a custom designed infrared thermal image system

Hwa

Liu³

et al. 2011

J. Biomed. Opt.

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“…It has been shown that the tear film thickness is thinner in dry eye patients. 6,7 Furthermore, wearing contact lenses interferes with the tear system, which may cause contact lens-related dry eye. 8 It is more common for contact lens wearers to develop the DES than the general population.…”

Section: Introductionmentioning

confidence: 99%

Tear film measurement by optical reflectometry technique

Wang

et al. 2014

J. Biomed. Opt

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Abstract. Evaluation of tear film is performed by an optical reflectometer system with alignment guided by a galvanometer scanner. The reflectometer system utilizes optical fibers to deliver illumination light to the tear film and collect the film reflectance as a function of wavelength. Film thickness is determined by best fitting the reflectance-wavelength curve. The spectral reflectance acquisition time is 15 ms, fast enough for detecting film thickness changes. Fast beam alignment of 1 s is achieved by the galvanometer scanner. The reflectometer was first used to evaluate artificial tear film on a model eye with and without a contact lens. The film thickness and thinning rate have been successfully quantified with the minimum measured thickness of about 0.3 μm. Tear films in human eyes, with and without a contact lens, have also been evaluated. A high-contrast spectral reflectance signal from the precontact lens tear film is clearly observed, and the thinning dynamics have been easily recorded from 3.69 to 1.31 μm with lipid layer thickness variation in the range of 41 to 67 nm. The accuracy of the measurement is better than AE0.58% of the film thickness at an estimated tear film refractive index error of AE0.001. The fiber-based reflectometer system is compact and easy to handle.

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Interferometry in the Evaluation of Precorneal Tear Film Thickness in Dry Eye

Cited by 83 publications

References 25 publications

Age-related differences in corneal epithelial thickness measurements with anterior segment optical coherence tomography

Age-related differences in corneal epithelial thickness measurements with anterior segment optical coherence tomography

Noncontact detection of dry eye using a custom designed infrared thermal image system

Tear film measurement by optical reflectometry technique

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