Interferon‐alpha prevents selection of doxorubicin‐resistant undifferentiated‐androgen‐insensitive metastatic human prostate cancer cells

Kuniyasu, Hiroki; Yasui, Wataru; Pettaway, Curtis A.; Yano, Seiji; Oue, Naohide; Tahara, Eiichi; Fidler, Isaiah J.

doi:10.1002/pros.1114

Cited by 19 publications

(15 citation statements)

References 43 publications

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“…The findings of the current study are consistent with those of our previous studies, which showed that metastatic potential is located at the tumor periphery [31,32] . We previously demonstrated that cancer cells at the tumor periphery express metastasis-associated genes, such as EGFR and MMP-2/-9, and repress E-cadherin [31,32] , which might be triggered by CSC induction at the tumor periphery.…”

Section: Discussionsupporting

confidence: 83%

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Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model

Kawahara

Mori²,

Goto³

et al. 2017

Pathobiology

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The potential effects of 2 types of fatty acids on colorectal cancer (CRC) were assessed using cancer stromal cells. Linoleic acid (LA; C-18, n-6 unsaturated fatty acid) and elaidic acid (EA; C-18, trans acid), both known to affect colon carcinogenesis and cancer progression, were administered by gavage to BALB/c mice, which were inoculated with CT26 syngeneic colon cancer cells in the back. Both EA and LA treatments enhanced tumor growth and metastasis. EA and LA also increased the number of CD133-positive stromal cells in the tumor capsule. Importantly, those cancer cells at the tumor periphery, physically attached to CD133-positive stromal cells, also expressed CD133. These findings suggest that EA and LA might induce stemness in cancer cells through physical association and promote cancer metastasis.

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Section: Discussionsupporting

confidence: 83%

“…We previously demonstrated that cancer cells at the tumor periphery express metastasis-associated genes, such as EGFR and MMP-2/-9, and repress E-cadherin [31,32] , which might be triggered by CSC induction at the tumor periphery.…”

Section: Discussionmentioning

confidence: 99%

Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model

Kawahara

Mori²,

Goto³

et al. 2017

Pathobiology

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“…Immunoprecipitation was performed according to the method described previously (Kuniyasu et al , 2001). The lysates were pre-cleaned in lysis buffer with protein A/G agarose (Santa-Cruz) for 1 h at 4 °C and subsequently centrifuged.…”

Section: Methodsmentioning

confidence: 99%

Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma

et al. 2013

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Background:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC).Methods:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression.Results:MIA2 expression was observed in 62 (66.7%) of 93 OSCCs and was associated with tumour expansion and nodal metastasis. Melanoma inhibitory activity 2 expression was inversely correlated with intratumoral infiltration of lymphocytes. Invasion and anti-apoptotic survival were reduced by MIA2 knockdown in HSC3 cells. MOLT-3 lymphocytes infiltrating the HSC3 cell layer was enhanced by MIA2 knockdown or MIA2 depletion with the antibody. In HSC3 cells, MIA2 knockdown decreased the expressions of vascular endothelial growth factor (VEGF), VEGF-C, and VEGF-D. The downregulation of VEGF-C and -D was caused by inhibition of p38 and extracellular signal-regulated kinase (ERK)1/2, respectively. Melanoma inhibitory activity 2 was co-precipitated with integrin α4 andα5 in HSC3 cells. Integrin α4 knockdown decreased p38 phosphorylation and increased apoptosis, whereas integrin α5 knockdown decreased c-Jun N-terminal kinase (JNK) phosphorylation and apoptosis. Inhibition of JNK decreased apoptosis in the HSC3 cells.Conclusion:These findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase.

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“…WiDr cells (5 ϫ 10 5 ) treated with HMGB1/amphoterin anti-sense or sense S-ODN were grown in six-well plates coated with 1% agarose (Sigma Chemical Co.) and incubated at 37°C in 5% CO 2 . 22 After 24 hours, multicellular spheroids (300 to 500 m in diameter) were co-cultured with PMA-U937 cells, surface-labeled with PKH26 chemifluorescent dye (Zynaxis, Inc., Malvern, PA). Infiltration of labeled cells was observed at 480 nm with a fluorescence microscope.…”

Section: Spheroid Infiltration Assaymentioning

confidence: 99%

Colon Cancer Cell-Derived High Mobility Group 1/Amphoterin Induces Growth Inhibition and Apoptosis in Macrophages

Kuniyasu

Yano

Sasaki

et al. 2005

The American Journal of Pathology

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105

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High mobility group (HMGB)1/amphoterin is a multifunctional cytokine involved in invasion and metastasis of cancer and in inflammation. To investigate HMGB1/amphoterin effects on macrophages, U937 human monocytic leukemia cells and rat peritoneal and human alveolar macrophages were examined. U937 cells expressed low levels of an HMGB1/amphoterin receptor, receptor for advanced glycation end-products (RAGE), whereas RAGE production was induced in differentiated phorbol 12-myristate 13-acetate (PMA)-U937 cells. Treatment with cultured medium of HMGB1/amphoterin-secreting WiDr human colon cancer cells showed growth inhibition of both U937 and PMA-U937 cells and apoptosis in PMA-U937 cells. The number of PMA-U937 cells was markedly decreased by co-culture with WiDr cells exposed to HMGB1/amphoterin sense S-oligodeoxynucleotide (ODN) in spheroids or monolayers. In contrast, PMA-U937 cells co-cultured with WiDr cells exposed to HMGB1/amphoterin anti-sense S-ODN were preserved in number. PMA-U937 cells exposed to RAGE anti-sense S-ODN were insensitive to WiDr-cultured medium. Recombinant human HMGB1/amphoterin induced growth inhibition in thioglycollate-induced rat peritoneal macrophages, PMA-U937 cells, and human alveolar macrophages, an effect that was abrogated by absorption with anti-HMGB1 antibody. Phosphorylation of JNK and Rac1 was induced in PMA-U937 cells treated with HMGB1/amphoterin. These results suggest that HMGB1/amphoterin induces growth inhibition and apoptosis in macrophages through RAGE intracellular signaling pathway.

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Interferon‐alpha prevents selection of doxorubicin‐resistant undifferentiated‐androgen‐insensitive metastatic human prostate cancer cells

Abstract: Treatment with IFN-alpha and DOX should be further explored as a therapeutic strategy for androgen-insensitive prostate cancer.

Cited by 19 publications

References 43 publications

Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model

Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model

Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma

Colon Cancer Cell-Derived High Mobility Group 1/Amphoterin Induces Growth Inhibition and Apoptosis in Macrophages

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