Interferon-Based Therapy for Hepatitis C Virus Infections

Yu, Ming‐Lung; Chuang, Wan–Long

doi:10.1007/978-0-387-71376-2_9

Cited by 1 publication

(2 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First of all, host genetic variations among different races are probably involved in the efficacy of IFN‐based therapies for CHC 88 . Genetic polymorphisms of human leukocyte antigen, TNF‐α‐308 promoter gene, CC chemokine receptor 5, cytotoxic T lymphocyte antigen–4, interleukin‐10, low molecular mass polypeptide 7, MxA, transforming growth factor–β1, and suppressor of cytokine signalling 3 gene have been reported to have significant associations with responsiveness 29,89–92 . These results reflect the important role of unique host genetic predisposition, at least in part, in the response to IFN‐based therapy for CHC.…”

Section: Racial Differences In Response To Ifn‐based Therapy: Better mentioning

confidence: 92%

See 1 more Smart Citation

Treatment of chronic hepatitis C in Asia: When East meets West

Chuang

2009

J of Gastro and Hepatol

Self Cite

241

250

View full text Add to dashboard Cite

The issue of best treatment for chronic hepatitis C virus (HCV) infection is in constant flux, not only in Western countries but also in Asia. Currently, pegylated-interferon plus ribavirin is the standard of care. Studies from Asia provide evidence to support the same broad treatment strategies for Asian patients as recommended in Western countries. Nevertheless, there is increasing evidence that Asians have a higher likelihood of achieving a sustained virological response (SVR) than their Caucasians counterparts when treated with the corresponding regimen. With the recommended 'standard dose and duration treatment regimens', SVR is achieved in Asia for around 70% of HCV genotype 1 (HCV-1) infected cases,~90% of HCV-2/3,~65% of HCV-4, and 80% of HCV-6 patients. Difference of body weight in race might contribute the superior response in Asian patients. HCV genotype distribution in Asia also differs from North-America/Europe. HCV-6 and its variants, previously mistyped as HCV-1, needs accurate genotyping. Increasing data support the proposal that HCV genotype, baseline viral load and on-treatment virological response provide information for decision-making so that treatment can be individualized. Beyond the older recommendations, an abbreviated 24-week regimen could be suggested for HCV-1/4 patients with baseline viral loads < 400 000 IU/mL and a rapid virological response (RVR, HCV RNA undetectable at week 4), and an abbreviated 12-16 weeks of pegylated-interferon with weight-based doses of ribavirin could be suggested for HCV-2/3 patients with a RVR. Such tailored treatment regimens can reduce the costs of treatment and incidence of adverse events without compromising efficacy.Hepatitis C virus (HCV) infection is one of the most important causes of cirrhosis worldwide, and particularly in some countries of Asia (notably Japan) where it is now more prevalent than chronic hepatitis B virus infection. Hepatitis C virus infection can also lead to hepatocellular carcinoma (HCC). It is estimated that there are more than 170 million people chronically infected with HCV, and 3 to 4 million persons are newly infected each year.1 The risk for developing cirrhosis 20 years after initial HCV infection among those chronically infected varies between studies, but is estimated at around 10%-15% for men and 1-5% for women. 2Once cirrhosis is established, the rate of developing HCC is at 1%-4% per year. Approximately 280 000 deaths per year are related to HCV infection.1 Hepatitis C virus-related end-stage liver disease and HCC have become the leading cause for liver transplantation worldwide. 3 In the Asia-Pacific area, the estimated prevalence of antibodies to HCV (anti-HCV) range from 0.3% in New Zealand to 5.6% in Thailand. [3][4][5] In Japan, Middle East, Vietnam and Taiwan, several HCV hyper-endemic areas have been reported with an anti-HCV prevalence rate of 12% to as high as 58%. 3,6 In addition to the well-known endemic status of HBV infection in most countries of the Asia-Pacific region, HCV infection presents...

show abstract

Section: Racial Differences In Response To Ifn‐based Therapy: Better mentioning

confidence: 92%

“…2). [27][28][29] improve the prediction of patients who are likely to achieve an SVR and may allow for tailoring of treatment duration.…”

Section: Definition Of Virological Responses For Treatment Of Hepatitmentioning

confidence: 99%