Interferon-beta exposure in-utero and the risk of infections in early childhood

Windfeld-Mathiasen, Josefine; Horwitz, Henrik; Andersen, Johanna Balslev; Framke, Elisabeth; Gade, Christina; Andersen, Jón Trærup; Magyari, Melinda

doi:10.1016/j.msard.2023.104867

Multiple Sclerosis and Related Disorders

2023

DOI: 10.1016/j.msard.2023.104867

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Interferon-beta exposure in-utero and the risk of infections in early childhood

Josefine Windfeld-Mathiasen

Henrik Horwitz

Johanna Balslev Andersen

et al.

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2024

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Children born preterm or small for gestational age to mothers with multiple sclerosis: Do these children have an increased risk of infections in early life?

Andersen,

Jølving,

Iachina

et al. 2024

Mult Scler

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Background: Mothers with multiple sclerosis are at increased risk of preterm birth and small for gestational age infants. Both conditions pose a risk of morbidity, including early-life infections. Objective: This study aimed to assess the risk of infections in the first 3 years of life among children born preterm or small for gestational age to mothers with multiple sclerosis. Methods: We used Danish national health registers to establish the study cohort of all births by women with MS born from 1995 to 2023. In Cox regression models, we estimated hazard ratios (HRs) of infections in preterm or small for gestational age children. Results: Preterm children had an adjusted HR of 1.49 (95% confidence interval (95% CI) 1.15–1.93) for hospital-diagnosed infection and 0.88 (95% CI 0.72–1.06) for antibiotic prescriptions. Small for gestational age children had an adjusted HR of 0.81 (95% CI 0.54–1.22) for hospital-diagnosed infection and 1.07 (95% CI 0.82–1.38) for antibiotic prescriptions. Conclusion: Children born preterm to mothers with multiple sclerosis had an increased risk of hospital-diagnosed infections in the first 3 years of life, but not of mild-to-moderate infections evaluated on prescriptions. Children born small for gestational age did not have an increased risk of infections.

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Children born preterm or small for gestational age to mothers with multiple sclerosis: Do these children have an increased risk of infections in early life?

Andersen,

Jølving,

Iachina

et al. 2024

Mult Scler

View full text Add to dashboard Cite

show abstract

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Interferon-beta exposure in-utero and the risk of infections in early childhood

Cited by 1 publication

References 25 publications

Children born preterm or small for gestational age to mothers with multiple sclerosis: Do these children have an increased risk of infections in early life?

Children born preterm or small for gestational age to mothers with multiple sclerosis: Do these children have an increased risk of infections in early life?

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