Interferon Eyedrops in the Treatment of Basal Cell Carcinoma of the Eyelid

Leis-Dosil, V.M.; Prats-Caelles, I.; Rubio-Flores, C.

doi:10.1016/j.adengl.2013.02.016

Cited by 4 publications

(5 citation statements)

References 10 publications

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Section: Basal Cell Carcinomamentioning

confidence: 99%

“…Interferons are a naturally occurring family of pleiotropic cytokines with antitumoral effects [46]. Intralesional interferon has been administered to BCCs with an effectiveness of 67-80% [46,47]. This modality was used in a series of 11 periocular BCCs, 7 of them with local aggressivity features.…”

Section: Basal Cell Carcinomamentioning

confidence: 99%

“…After a year of follow-up, there were no documented recurrences, and only one patient experienced associated flu-like symptoms [47]. Ophthalmic interferon has been applied in clinical practice to treat multiple ocular surface lesions, such as warts, SCC, Kaposi sarcoma, or even melanoma [46]. The usual dosage is an eyedrop (1 million UI/mL) four times a day, over 12-16 weeks.…”

Section: Basal Cell Carcinomamentioning

confidence: 99%

“…The usual dosage is an eyedrop (1 million UI/mL) four times a day, over 12-16 weeks. This regimen was given in a case of eyelid margin BCC, which did not recur after 3 years of follow-up [46].…”

Section: Basal Cell Carcinomamentioning

confidence: 99%

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Topical and Intralesional Immunotherapy for the Management of Skin Cancer in Special Locations: Lips and Eyelids

Buján Bonino,

Rodríguez-Blanco,

Sánchez-Aguilar Rojas

et al. 2023

Cancers

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The use of topical and intralesional immunotherapy in the treatment of cutaneous malignant neoplasia in sensitive areas such as the lips and eyelids is discussed. Surgery may not be feasible or may result in deformities in these areas, making alternative treatment options necessary. A narrative literature review was conducted using MEDLINE (PubMed) as the main literature database, collecting available evidence of experiences with various topical and intralesional therapies in the aforementioned anatomical locations, ranging from case reports to clinical trials. The clearance rates and potential adverse reactions of therapeutic options such as imiquimod 5%, 5-fluorouracil (5-FU), photodynamic therapy (PDT), ingenol mebutate (IM), diclofenac, intralesional methotrexate, and interferon are reviewed. Although limited by their heterogeneity and the scarcity of clinical trials, these studies point towards promising response rates and minimal adverse effects, making these treatments viable options in selected cases.

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Section: Basal Cell Carcinomamentioning

confidence: 99%

Section: Basal Cell Carcinomamentioning

confidence: 99%

Section: Basal Cell Carcinomamentioning

confidence: 99%

Section: Basal Cell Carcinomamentioning

confidence: 99%

See 2 more Smart Citations

Topical and Intralesional Immunotherapy for the Management of Skin Cancer in Special Locations: Lips and Eyelids

Buján Bonino,

Rodríguez-Blanco,

Sánchez-Aguilar Rojas

et al. 2023

Cancers

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“…[ 20 ] IFN-α-2b eyedrops have been proposed for the management of BCC as an adjuvant at a dose of 1 drop of IFN-α-2b at 1 million IU/mL 4 times per day for 3 to 4 months and 1 drop every 12 hours as maintenance therapy. [ 21 ] No side effects have been reported with topical therapy.…”

Section: Introductionmentioning

confidence: 99%

Topical non-steroidal immunomodulators in dermatology

Kadu¹

2023

Indian Dermatol Online J

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Immunological abnormality is the pathological basis of many dermatological disorders. Although steroids are the backbone of topical therapy in dermatology, the side effects are encountered quite frequently. Thorough knowledge of non-steroidal immunomodulators will broaden our treatment options. A summary of important non-steroidal immunomodulators has been given to help the residents understand the mechanism of action, indications, application, and adverse effects of these drugs.

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