2018
DOI: 10.1088/1755-1315/125/1/012147
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Interferon-gamma and interleukin-10 profile of children with tuberculosis in North Sumatera, Indonesia

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Cited by 5 publications
(5 citation statements)
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“…This study only examined one polymorphism while many polymorphisms in IFN-γ genes affect the expression of this gene and this IFN-γ +874 T/A have been studied in children [24]. This study also did not examine the levels of IFN-γ which was associated with the polymorphism +874 T/A of the IFN-γ gene.…”
Section: Hwementioning
confidence: 99%
“…This study only examined one polymorphism while many polymorphisms in IFN-γ genes affect the expression of this gene and this IFN-γ +874 T/A have been studied in children [24]. This study also did not examine the levels of IFN-γ which was associated with the polymorphism +874 T/A of the IFN-γ gene.…”
Section: Hwementioning
confidence: 99%
“…The PBMCs were carried out and washed twice with PBS, then added with complete RPMI media. PBMCs in number of 5x10 5 were cultured in 24-well plates with complete RPMI media, then treated with/without 5 μg/mL b-glucan (Merck KGaA, Darmstadt, Germany) and 10 μg/mL M. tuberculosis wild-type or mutant DNA. PBMCs were incubated in a humidified incubator of 5% CO 2 at 37°C for 6 days.…”
Section: Pbmcs Isolation and Inductionmentioning
confidence: 99%
“…However, insufficient amounts due to immune cells weakening, could be happened in children. (5) To increase the production of cytokines, immune cells need to get external immunomodulators. b-glucan, a potent immunomodulator, can affect both innate and adaptive immune systems through various mechanisms.…”
Section: Introductionmentioning
confidence: 99%
“…Human immune response has a potential implication in the control and prevention of TB disease, thus it is so essential to comprehend its regulation; especially the cell-mediated immune response that influenced the main response of the host against M. tuberculosis, in which important role is attributed to cytokine and T helper-1 cells. 1 Many factors can affect this response, one of them is the micronutrients, copper, and zinc have a vital role in the growth, differentiation, and proliferation of cells of acquired and innate immunity. Both these nutrients play a crucial role in the resistance of the human body to certain infections as tuberculosis.…”
Section: Introductionmentioning
confidence: 99%