Interferon-gamma gene polymorphism influences the frequency of a<i>Chlamydia trachomatis</i>cervical infection in young women

Eleutério, José; Teles, Rosiane Alves de Sousa; Linhares, Iara M.; Normand, Neil

doi:10.1177/0956462414563627

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Individual variations in the ease of IFN-␥ induction and the extent of its production in response to specific infections may determine which of the two mechanisms predominates. We have demonstrated that women positive for a single nucleotide polymorphism associated with elevated IFN-␥ production (rs2430561) had a lower likelihood of having a C. trachomatis cervical infection than did women who were negative for this variant allele (35). Thus, the extent of IFN-␥ production in individual women most likely also influences the likelihood of chlamydial survival.…”

Section: Trachomatis Persistencementioning

confidence: 90%

Chlamydia trachomatis: the Persistent Pathogen

Witkin

Minis

Athanasiou

et al. 2017

Clin Vaccine Immunol

166

117

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Chlamydia trachomatis is an obligate intracellular bacterium whose only natural host is humans. Although presenting as asymptomatic in most women, genital tract chlamydial infections are a leading cause of pelvic inflammatory disease, tubal factor infertility, and ectopic pregnancy. C. trachomatis has evolved successful mechanisms to avoid destruction by autophagy and the host immune system and persist within host epithelial cells. The intracellular form of this organism, the reticulate body, can enter into a persistent nonreplicative but viable state under unfavorable conditions. The infectious form of the organism, the elementary body, is again generated when the immune attack subsides. In its persistent form, C. trachomatis ceases to produce its major structural and membrane components, but synthesis of its 60-kDa heat shock protein (hsp60) is greatly upregulated and released from the cell. The immune response to hsp60, perhaps exacerbated by repeated cycles of productive infection and persistence, may promote damage to fallopian tube epithelial cells, scar formation, and tubal occlusion. The chlamydial and human hsp60 proteins are very similar, and hsp60 is one of the first proteins produced by newly formed embryos. Thus, the development of immunity to epitopes in the chlamydial hsp60 that are also present in the corresponding human hsp60 may increase susceptibility to pregnancy failure in infected women. Delineation of host factors that increase the likelihood that C. trachomatis will avoid immune destruction and survive within host epithelial cells and utilization of this knowledge to design individualized preventative and treatment protocols are needed to more effectively combat infections by this persistent pathogen.

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Section: Trachomatis Persistencementioning

confidence: 90%

Chlamydia trachomatis: the Persistent Pathogen

Witkin

Minis

Athanasiou

et al. 2017

Clin Vaccine Immunol

166

117

View full text Add to dashboard Cite

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“…Таким чином, при зниженні рівня ІФН-γ після елімінації ЕТ, РТ, що увійшли в персистентний стан, можуть знову почати ділення [18,19]. Індивідуальні генетично детерміновані особливості утворення ІФН-γ також впливають на інфікування C. trachomatis, характер клінічного перебігу та розвиток наслідків [20].…”

Section: хламідійна інфекція сучасні дані про патогенезunclassified

Epidemiological and clinical trends of sexually transmitted infections. Literature review

Тутченко¹,

Бурка

Boyarchuk

et al. 2021

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This article presents modern data on epidemiological trends, pathogenesis, and mechanisms of persistence and acquisition of antibiotic resistance of the most common sexually transmitted infections (STIs): chlamydial infection, gonorrhea, trichomoniasis. Data on the frequency of chlamydial infection, gonorrhea, trichomoniasis detection in the DILA medical laboratory in the period from 2018–2020 are also presented.Analysis of epidemiological and microbiological studies indicates a significant increase in the STIs incidence in countries with high economic development and the need for constant revision of diagnostic and treatment approaches, based on new data on the pathogens physiology, mechanisms and levels of antibiotic resistance, possibilities of laboratory diagnostics. Analysis of the DILA data on the chlamydial infection, gonorrhea, trichomoniasis detection is coinciding with the world trends in the increase of their prevalence. At the same time, the analysis of the DILA data demonstrated an interesting clinical phenomenon as a presence of 2 STIs peaks in women: the first at 21–25 years and the second at 51–55 years old.Clinical manifestations of STIs are increasingly losing their typical features today. This indicates the need for a laboratory search for all common STIs in the region. Knowledge of the etiological factor of the inflammatory process allows choosing the correct antibiotic therapy and preventing the further development of antibiotic resistance. This article presents data on the various methods of STIs laboratory tests. Regular visits of women for cervical cancer screening are a good opportunity to screen for STIs. The ability to detect STIs in biomaterial in liquid cytology makes this option more accessible.Thus, since vaccines against common bacterial and protozoa STIs pathogens have not yet been developed, the promotion of hygiene of sexual behavior and timely detection of infected persons during examination or screening with subsequent etiopathogenetic treatment are the basis of the STIs control systems and their consequences prevention.

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Biocenosis of the vagina. Norm. Disruption. Restoration

Radzinskiy,

Savicheva,

Vorob'ev

et al. 2023

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A healthy reproductive system is inconceivable without normal vaginal microbiota, and full-fledged treatment cannot be carried out without detailed understanding of the arrangement and functions of the human microbiome. Today superbugs are a reality, and the role of such concepts as “microbiome” and “biofilms” is already undeniable in medical practice. Every doctor understands that it is necessary to choose antibacterial drugs based on practicability, global experience and evidence-based medicine. All this clearly demonstrates that there is a need to create an authoritative source of knowledge — a handbook for practitioners. Each chapter contains up-to-date information on the impact of female microbiota on the course and outcomes of pregnancy, on the etiology, pathogenesis and diagnostics of vaginal microbiocenosis disorders, and detailed treatment regimens. The work is intended for obstetrician-gynecologists and heads of women’s health clinics, perinatal centers, departments of general hospitals, fellows and heads of departments of obstetrics and gynecology, students of all forms of continuous medical education, graduate students and clinical residents, as well as students of medical schools.

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Interferon-gamma gene polymorphism influences the frequency of aChlamydia trachomatiscervical infection in young women

Cited by 3 publications

References 35 publications

Chlamydia trachomatis: the Persistent Pathogen

Chlamydia trachomatis: the Persistent Pathogen

Epidemiological and clinical trends of sexually transmitted infections. Literature review

Biocenosis of the vagina. Norm. Disruption. Restoration

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