Interferon-Gamma Release Assay in a Patient with Tuberculosis Verrucosa Cutis

Kim, Geon; Jeong, Young-In; Huh, Jae Won; Kim, Eun-Jung; Joh, Ok-Ja

doi:10.5021/ad.2015.27.1.109

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…The positivity rates in acid-fast bacilli culture and DNA PCR, and detection of M. tuberculosis in Ziehl-Neelsen stain are relatively low because the bacillary load in cutaneous Tbc is less than that in other forms of Tbc (6). IGRA is used as a good diagnostic aid in obtaining detective evidence of M. tuberculosis in TVC (7). Moreover, remarkable response to anti-Tbc therapy might be useful as a diagnostic criterion (5).…”

Section: Diagnosis: Tuberculosis Verrucosa Cutismentioning

confidence: 99%

Long-standing Verrucous Plaques on the Buttocks: A Quiz

Eun

Kim²,

Choi³

et al. 2018

Acta Derm Venerol

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Section: Diagnosis: Tuberculosis Verrucosa Cutismentioning

confidence: 99%

Long-standing Verrucous Plaques on the Buttocks: A Quiz

Eun

Kim²,

Choi³

et al. 2018

Acta Derm Venerol

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“…6 There is no reported sensitivity for QuantiFERON in cutaneous TB, though it has tested positive in other cases of TVC. 7,8 Treatment is with multidrug antituberculosis therapy, which was effective in our case. In clinically suspicious cases with negative PCR, significant improvement with empirical TB treatment can corroborate the diagnosis.…”

Section: Discussionmentioning

confidence: 74%

“…TB is an enzyme‐linked immunospot (ELISPOT) assay with a sensitivity of 91.6% for cutaneous TB 6 . There is no reported sensitivity for QuantiFERON in cutaneous TB, though it has tested positive in other cases of TVC 7,8 …”

Section: Discussionmentioning

confidence: 99%

Chronic violaceous plaques on the arm

Brent,

Amoafo,

Wijesuriya

et al. 2023

Int J Dermatology

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A 45-year-old man originally from Pakistan presented with a 1year history of two increasingly raised and nodular plaques on his left arm, arising from areas of hyperpigmentation he reports were present from birth. He habitually scratched the lesions. He had no relevant past medical or family history and denied contact with animals, fish tanks, or recent travel abroad. He was systemically well. Physical examination revealed hyperkeratotic violaceous plaques on the left wrist and left medial elbow (Figure 1a-c). There was no regional lymphadenopathy. Blood tests showed normal full blood count, renal, liver, and bone profiles, and hepatitis B, C, HIV, and TB QuantiFERON were negative. A chest x-ray was unremarkable.

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“…The results can be affected by immune system or nutritional status, or concomitant corticosteroid use, which can interfere with the interpretation of the results. Moreover, the test is influenced by previous BCG vaccination, so it can be misinterpreted in South Korea where children are routinely given BCG vaccination owing to the high prevalence of TB infection 16 .…”

Section: Discussionmentioning

confidence: 99%

Multiple Skin Colored Nodules on both Legs in Patient with Positive QuantiFERON®-TB Gold Test

et al. 2017

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Nodular tuberculid (NT) was originally described by Jordaan et al. in 2000 in 4 patients from South Africa. It appeared as nodules on the legs; the pathologic changes were situated in the deep dermis and adjacent subcutaneous fat. A 34-year-old woman visited our hospital with subcutaneous skin-colored or slightly erythematous round to oval nodules. Skin biopsies revealed granulomatous inflammation at the dermo-subcutaneous junction with vasculitis. Chest X-ray, tuberculosus (TB)-polymerase chain reaction and TB culture of the skin specimen were normal. A QuantiFERON®-TB Gold test (QUIAGEN, Germany) was positive, which suggested a diagnosis of latent TB infection. The patient was treated with anti-TB medication and her condition has not recurred. Herein, we report a case of a patient with latent TB diagnosed by a positive QuantiFERON®-TB Gold test whose skin lesions had the clinical and histopathologic features of NT.

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Interferon-Gamma Release Assay in a Patient with Tuberculosis Verrucosa Cutis

Cited by 6 publications

References 3 publications

Long-standing Verrucous Plaques on the Buttocks: A Quiz

Long-standing Verrucous Plaques on the Buttocks: A Quiz

Chronic violaceous plaques on the arm

Multiple Skin Colored Nodules on both Legs in Patient with Positive QuantiFERON®-TB Gold Test

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