Interferon Gamma Release Assays for Latent <i>Mycobacterium tuberculosis</i> Detection in Elderly Hispanics

Jm, Scordo; Aguillon, G; Ayala, Doris; Ap, Quirino Cerrillo; Re, Rodriguez; Mora-Guzmán, Francisco; Ja, Caso; Ledezma-Campos, Eder; Villafañez, Alejandro; Ls, Schlesinger; Jb, Torrelles; Turner, Joanne; Restrepo, Blanca I.

doi:10.1101/2021.06.15.21258953

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings call for the need to consider the elderly in a similar high-risk category. A recent study showed that Interferon-gamma release assays (IGRA) are effective for identification of latent TB infection in the elderly [57]. We also identified modifiable sociodemographic factors associated with higher odds of death during TB in the elderly, such as excess alcohol use or low BMI.…”

Section: Discussionmentioning

confidence: 90%

Tuberculosis presentation and outcomes in elderly Hispanics from Tamaulipas, Mexico

Medrano¹,

Lee²,

Gemeinhardt

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Old people are at high risk of developing and dying from pulmonary infections like tuberculosis (TB), but they are few studies among them, and particularly in Hispanics. To address these gaps, we sought to identify host factors associated with TB and adverse treatment outcomes in old Hispanics by conducting a secondary analysis of TB surveillance data from Tamaulipas, Mexico (2006-2013; n=8,381). Multivariable logistic regressions were assessed for the elderly (ELD, ≥65 years) when compared to young (YA, 18 to 39 years) and middle-aged adults (MAA, 40 to 64 years). We found that the ELD had features associated with a less complicated TB (e.g. less extra-pulmonary TB, abandoning of treatment or having drug resistant TB), and yet, were more likely to die (adj-OR 3.9, 95% 2.5, 5.25). Among the elderly, excess alcohol use and low BMI increased their odds of death, while diabetes and BCG vaccination were protective. These data suggest that old people share some, but not all the risk factors for adverse TB treatment outcomes, when compared with YA or MAA. Furthermore, even though old age in itself is an important predictor of death during TB, old people are not prioritized by the World Health Organization for latent TB infection screening and treatment during contact investigations. We propose the inclusion of the elderly as a high-risk group in TB management guidelines.

show abstract

Section: Discussionmentioning

confidence: 90%