Interferon-Inducible Protein 10 and Disease Activity in Systemic Lupus Erythematosus and Lupus Nephritis: A Systematic Review and Meta-Analysis

Puapatanakul, Pongpratch; Chansritrakul, Sonchai; Susantitaphong, Paweena; Ueaphongsukkit, Thornthun; Eiam‐Ong, Somchai; Praditpornsilpa, Kearkiat; Kittanamongkolchai, Wonngarm; Avihingsanon, Yingyos

doi:10.3390/ijms20194954

Cited by 33 publications

(43 citation statements)

References 45 publications

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“…3,4 CXCL-10 is a chemokine that is a good biomarker for active SLE; however, it failed to differentiate active renal from active non-renal disease in a recent metanalysis. 5 Of late, galectin-9 was evaluated as an easy to measure and better biomarker than CXCL-10 to identify the IFN signature in SLE. 6,7 Galectin-9 is a β-galactoside-binding lectin that exhibits multiple immunomodulatory functions including apoptosis of activated T cells, inhibition of Th1 and Th17 responses, and promotion of the differentiation of regulatory T cells.…”

Section: Introductionmentioning

confidence: 99%

Serum and urinary galectin-9 and C-X-C motif chemokine ligand 10

Mehta

Singh

Aggarwal

2022

Lupus

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Background Systemic lupus erythematosus (SLE) is characterized by a type I interferon (IFN) signature, and traditional methods for its measurement like gene expression analysis are cumbersome for routine use. Thus, we aimed to study galectin-9 as a biomarker and compared it with a validated marker, C-X-C motifchemokine ligand 10(CXCL-10). Methods Ninety-seven patients with SLE (26 years; 89 females) were included and stratified based on renal involvement and activity into - active (SLEDAI > 4) renal (35), active non-renal (32) and inactive renal subgroups (30) along with 20 healthy controls (HC, 25 years; 15 females). The median disease duration was 24 months (6-48), and SLEDAI 2K was 9 (2–15). Serum and urine galectin-9 and CXCL-10 levels were measured by ELISA. Urine levels were normalized with spot urine creatinine values. Follow-up serum and urine galectin-9 levels were measured for those in the active renal group at 6 months. Results Patients with SLE had higher serum galectin-9 (5.6 vs 1.7 μg/mL, p = .0001) but not urine galectin-9 (0.52 vs 0.32 μg, p = .7) levels as compared to HC. Serum galectin-9 but not urine galectin-9 was higher in patients with active as compared to inactive lupus (12.9 - active renal, 16.7 - active non-renal vs 3.57 μg/mL, p = .04 and .005). Serum CXCL-10 (0.16 vs 0.05, p = .01) and urine CXCL-10 (0 vs 0, p = .01) were both significantly higher in the SLE group as compared with HC. Serum but not urine CXCL-10 was higher in the active as compared to inactive lupus (0.2 - active renal, 0.3 - active non-renal vs 0.08 μg/mL, p = .9 and .02). Serum galectin-9 showed a modest correlation with CXCL-10 0.4 (0.2–0.6), whereas none was found between their urine levels. Serum galectin-9 and CXCL-10 showed a moderate positive correlation with SLEDAI 2K. Serum galectin-9 showed a greater AUC than CXCL-10 (0.77 vs 0.67) in differentiating active from inactive SLE, and both tested together had the best AUC of 0.82. However, urinary levels had no association with SLEDAI 2K or renal SLEDAI. In a subset of patients with active renal disease, serum galectin-9 but not urine levels declined significantly after 6 months. Conclusion Serum galectin-9 is a good marker of lupus activity; however, it does not differentiate between active renal and active non-renal disease. It performs slightly better than CXCL-10. Urinary galectin-9 does not reflect renal activity.

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Section: Introductionmentioning

confidence: 99%

Serum and urinary galectin-9 and C-X-C motif chemokine ligand 10

Mehta

Singh

Aggarwal

2022

Lupus

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“…(2) secretion of the interleukin-1beta (IL-1β) able to induce a Th2 response (humoral immune response). Figure 3C shows that the uptake of lipopolyamines/antigen complexes in vivo by intraperitoneal macrophages induced secretion of interleukin-5 (IL-5) and humoral immunity plus tumor necrosis factor-alpha (TNF-α) and gamma-interferon inducible protein (IP-10) [71], typical inducers of Th1 response (cell-mediated immune response) by the cultured macrophages.…”

Section: Assemblies From Cationic Lipids and Surfactantsmentioning

confidence: 99%

“…The possible toxicity in vivo of the lipopolyamine-OVA complexes was evaluated from or complexed with ovalbumin by cultured human cell lines transfected with Toll-like Receptors (TLRs), leading to 1) secretion of inflammatory and type-I interferon cytokines able to trigger a Th1 response (cell-mediated immunity); 2) secretion of the interleukin-1beta (IL-1β) able to induce a Th2 response (humoral immune response). (c) Uptake of lipopolyamines/antigen complexes in vivo by intraperitoneal macrophages induced secretion of interleukin-5 (IL-5) and humoral immunity plus tumor necrosis factor-alpha (TNF-α) and gamma-interferon inducible protein (IP-10) [71], typical inducers of Th1 response (cell-mediated immune response) by the cultured macrophages. Reprinted from [70] with permission from Elsevier, Copyright 2018.…”

Section: Assemblies From Cationic Lipids and Surfactantsmentioning

confidence: 99%

Cationic Nanostructures for Vaccines Design

Carmona-Ribeiro

Betancourt

2020

Biomimetics

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Subunit vaccines rely on adjuvants carrying one or a few molecular antigens from the pathogen in order to guarantee an improved immune response. However, to be effective, the vaccine formulation usually consists of several components: an antigen carrier, the antigen, a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a stimulator of humoral response such as an inflammasome activator. Most antigens are negatively charged and combine well with oppositely charged adjuvants. This explains the paramount importance of studying a variety of cationic supramolecular assemblies aiming at the optimal activity in vivo associated with adjuvant simplicity, positive charge, nanometric size, and colloidal stability. In this review, we discuss the use of several antigen/adjuvant cationic combinations. The discussion involves antigen assembled to 1) cationic lipids, 2) cationic polymers, 3) cationic lipid/polymer nanostructures, and 4) cationic polymer/biocompatible polymer nanostructures. Some of these cationic assemblies revealed good yet poorly explored perspectives as general adjuvants for vaccine design.

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“…10 Previous studies confirmed that the level of IP-10 was increased in SLE patients and correlated with the disease activity of SLE and the severity of lupus nephritis (LN). 11 It has also been reported that VDR agonists could inhibit the production and release of IP-10 in many cells such as T cells, human thyroid cells, renal tubular cells, cardiomyocytes, and pancreatic cells. [12][13][14] However, no previous study has investigated the relationship between VDR and cytokine IP-10 in SLE.…”

Section: Introductionmentioning

confidence: 98%

Vitamin D receptor is negatively correlated with interferon-γ-inducible protein-10 in systemic lupus erythematosus with renal involvement

Zhang

et al. 2020

Eur J Inflamm

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The vitamin D receptor (VDR) plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) mainly due to its anti-inflammatory and immunomodulatory activities. Interferon-inducible protein-10 (IP-10) is a chemokine found to be increased in SLE patients and correlated with severity of lupus nephritis. In this case control study, we investigated the connection between VDR expression and chemokine IP-10 in peripheral blood mononuclear cells (PBMCs) of SLE patients with or without renal involvement. 62 SLE patients and 30 healthy subjects were enrolled between 2014 and 2016. PBMC VDR mRNA and IP-10 mRNA were quantified by real-time PCR. PBMC VDR protein was measured by Western blotting. PBMC VDR mRNA and protein were downregulated, whereas IP-10 mRNA was upregulated in SLE patients with renal involvement. VDR mRNA levels were negatively correlated with systemic lupus international collaborating clinics (SLICC) renal activity scores (r = −0.423, P = 0.016) and IP-10 mRNA levels (r = −0.428, P = 0.008) in SLE with renal involvement. This study demonstrates that PBMC VDR was negatively correlated with SLICC renal activity and chemokine IP-10 in SLE patients with renal involvement which suggests that VDR downregulation may be used as an indicator of renal injury in SLE patients.

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Interferon-Inducible Protein 10 and Disease Activity in Systemic Lupus Erythematosus and Lupus Nephritis: A Systematic Review and Meta-Analysis

Cited by 33 publications

References 45 publications

Serum and urinary galectin-9 and C-X-C motif chemokine ligand 10

Serum and urinary galectin-9 and C-X-C motif chemokine ligand 10

Cationic Nanostructures for Vaccines Design

Vitamin D receptor is negatively correlated with interferon-γ-inducible protein-10 in systemic lupus erythematosus with renal involvement

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