Interferon Induction and Increased Natural Killer-Cell Activity in Influenza Infections in Man

Ennis, F A; Beare, A. S.; Riley, Diana; Schild, G. C.; Meager, Anthony; Qi, Yihua; Schwarz, G.; Rook, A H

doi:10.1016/s0140-6736(81)91390-8

Cited by 103 publications

(47 citation statements)

References 11 publications

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“…It was reported that in human volunteers experimentally challenged with wild-type influenza virus, infection caused a significant increase in NK cell activity (13). Despite the importance of innate immunity in host defense against viral infection, most previous immunological studies of influenza vaccines have focused on adaptive immunity, i.e., B-cell and T-cell responses, and rarely on innate immunity.…”

Section: Vol 80 2006 Human T-and Nk Cell Responses To Influenza Vacmentioning

confidence: 99%

“…Cellular immune responses, including innate NK responses and adaptive T-cell responses, are thought to play a pivotal role in clearing influenza virus infection; however, these conjectures are based primarily on studies in animal models (8,12,13,18,33,35,48). Few systematic studies of cellular immunity against influenza virus have been done in people, especially in young children (21,34).…”

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confidence: 99%

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Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines

Holmes

Zhang

et al. 2006

J Virol

294

242

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The patterns of cellular immune responses induced by live attenuated influenza vaccine (LAIV) versus those of the trivalent inactivated influenza vaccine (TIV) have not been studied extensively, especially in children. The goals of this study were to evaluate the effects of TIV and LAIV immunization on cellular immunity to live influenza A virus in children and adults and to explore factors associated with variations in responses to influenza vaccines among individuals. A gamma interferon (IFN-γ) flow cytometry assay was used to measure IFN-γ-producing (IFN-γ+) NK and T cells in peripheral blood mononuclear cell cultures stimulated with a live influenza A virus strain before and after LAIV or TIV immunization of children and adults. The mean percentages of influenza A virus-specific IFN-γ+ CD4 and CD8 T cells increased significantly after LAIV, but not TIV, immunization in children aged 5 to 9 years. No increases in the mean levels of influenza A virus-reactive IFN-γ+ T cells and NK cells were observed in adults given LAIV or TIV. TIV induced a significant increase in influenza A virus-reactive T cells in 6-month- to 4-year-old children; LAIV was not evaluated in this age group. The postvaccination changes (n-fold) in the percentages of influenza A virus-reactive IFN-γ+ T and NK cells in adults were highly variable and correlated inversely with the prevaccination percentages, in particular with that of the CD56dim NK cell subset. In conclusion, our findings identify age, type of vaccine, and prevaccination levels of immune reactivity to influenza A virus as factors significantly associated with the magnitude of cellular immune responses to influenza vaccines.

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Section: Vol 80 2006 Human T-and Nk Cell Responses To Influenza Vacmentioning

confidence: 99%

mentioning

confidence: 99%

Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines

Holmes

Zhang

et al. 2006

J Virol

294

242

View full text Add to dashboard Cite

show abstract

“…Natural killer (NK) cells are innate lymphocytes and are "first responders" against infection [8]. This capacity to respond quickly underlines their importance in acute respiratory infection [9][10][11]. NK cells also shape the subsequent adaptive immune response [12,13] and failure of this response may underlie severe disease, as suggested by autopsy studies on cases of fatal viral bronchiolitis [14].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-15 is associated with disease severity in viral bronchiolitis

et al. 2015

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Disease severity in viral bronchiolitis in infancy is difficult to predict and has been linked to host innate immunity. The study aimed to investigate the innate cytokine interleukin-15 (IL-15) as a marker of disease severity.A prospective single-centre observational study was conducted in a university-affiliated paediatric teaching hospital, comparing children (0-18 months) hospitalised for viral bronchiolitis, those admitted to the paediatric intensive care unit with severe disease and healthy age-matched controls. IL-15-related parameters were compared between groups. PCR and microRNA (miRNA) sequencing was undertaken on natural killer (NK) cells collected from study participants.Samples from 88 children with viral bronchiolitis and 43 controls enrolled between 2009 and 2012 were analysed. Peripheral blood mononuclear cell (PBMC) IL-15 mRNA expression was significantly higher in those with moderate severity bronchiolitis compared with controls and those with severe disease. Serum IL-15 levels correlated with disease severity. The relative frequency of NK cells in peripheral blood was significantly reduced in participants with bronchiolitis. The NK cell miRNA transcriptome in bronchiolitis was distinct. Targets of de-regulated miRNA were differentially expressed in bronchiolitis, including JAK3, STAT5A and NFKB1 on the IL-15 signalling pathway.IL-15 is associated with disease severity in children hospitalised with viral bronchiolitis.@ERSpublications Interleukin-15 influences the host innate response and is associated with disease severity in viral bronchiolitis

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“…Those shedding virus on both days had higher levels of serum interferon than those that shed on one day, or had no virus shedding. None of the recipients of placebo had detectable serum interferon, nor did they have an increase in natural killer cell activity (35).…”

Section: Studies In Humansmentioning

confidence: 89%

Some newly recognized aspects of resistance against and recovery from influenza

Ennis

1982

Archives of Virology

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Interferon Induction and Increased Natural Killer-Cell Activity in Influenza Infections in Man

Cited by 103 publications

References 11 publications

Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines

Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines

Interleukin-15 is associated with disease severity in viral bronchiolitis

Some newly recognized aspects of resistance against and recovery from influenza

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