1977
DOI: 10.1099/0022-1317-34-2-363
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Interferon Inhibits Mouse Leukaemia Virus Release: an Electron Microscope Study

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Cited by 71 publications
(16 citation statements)
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“…However, because there are multiple mechanisms for the antiviral action of IFNs (33), there are probably additional IFN pathways capable of suppressing XMRV. For instance, previous studies on MLV and the lentivirus HIV-1 showed that IFN inhibited viral assembly or release (16,17,34,35), a process that has not been shown to be affected by RNase L. Our future efforts will address the stage(s) in the replication cycle of XMRV that are suppressed by IFN.…”
Section: Rnase L Is Required For a Complete Ifn Antiviral Response Agmentioning
confidence: 98%
“…However, because there are multiple mechanisms for the antiviral action of IFNs (33), there are probably additional IFN pathways capable of suppressing XMRV. For instance, previous studies on MLV and the lentivirus HIV-1 showed that IFN inhibited viral assembly or release (16,17,34,35), a process that has not been shown to be affected by RNase L. Our future efforts will address the stage(s) in the replication cycle of XMRV that are suppressed by IFN.…”
Section: Rnase L Is Required For a Complete Ifn Antiviral Response Agmentioning
confidence: 98%
“…It has been suggested that the interferon block is due to the inhibition of release (Billiau et al 1973;Chang et al 1977) ' or to 'trapping' of the virus (Billiau et al I976a) by the cell membranes of the infecte~ oo22-I317/79/oooo-335 o $02.00 © I979 SGM cells. In these reports, however, the particles which accumulated on the cell surface of interferon-treated cells were examined only morphologically and no attempts were made to correlate the number of virions with their infectivity.…”
Section: Introductionmentioning
confidence: 99%
“…Alternatively, because treatment of both normal and transformed cells with IFN results in a significant reorganization of their cytoskeleton and extracellular matrix (2,4), it is possible that such changes could, in turn, play a role in altering the fluidity of the cell plasma membrane. In addition to these cellular changes, the observed inhibition of murine retrovirus replication by IFN appears to involve a block in assembly at the stage of virus release from the cell (28)(29)(30). Such a block in IFN-treated cells would be consistent with a stiffening of the plasma membrane because, under conditions such that the membrane is less fluid, the process of budding might be expected to represent the rate-limiting step in viral replication.…”
mentioning
confidence: 95%