Interferon-Related Bronchiolitis Obliterans Organizing Pneumonia

Ogata, Kenichi; Kinoshita, Toshihiko; Yagawa, Katsuro

doi:10.1378/chest.106.2.612

Cited by 59 publications

(25 citation statements)

References 5 publications

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“…Paraquat ingestion usually results in diffuse alveolar damage, but hyaline membranes were not present in a fatal case with intra-alveolar fibrosis [310]. Organising pneumonia has been Amiodarone [90,230,[233][234][235][236][237][238][239][240] Amphotericin B [241] Bleomycin [18,[242][243][244][245][246][247][248][249][250][251][252] Busulfan [230,253,254] Busulfan and cyclophosphamide [230] Carbamazepine [255,256]; in association with carbamazepine induced lupus [257] Cephalosporin (cefradin) [258] Chlorambucil [259] Doxorubicin Possible recall after radiation to the breast [260] Fluvastatin [261] Gold salts [262,263] Hexamethonium [264] Interferon-a [264,265] Interferon-a2b, pegylated interferon a2b [266] Interferon-a + cytosine arabinoside [267] Interferon + ribavirin [266] Interferon-b1a [268,…”

Section: Fungimentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

Eur Respir J

485

466

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Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organising pneumonia when no cause or peculiar underlying context is found. Rapid clinical and imaging improvement is obtained with corticosteroid treatment, but relapses are common after stopping treatment.

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Section: Fungimentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

Eur Respir J

485

466

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“…4), and the increase in lymphocytes associated with elevated CD8+ cells in BALF (Case Nos. 1 and 4), and since interferoninduced BOOP was also reported [8], it is important to differentiate these cases from acute eosinophilic pneumonia, hypersensitivity pneumonitis and BOOP. Acute eosinophilic pneumonias [20,21], which present a febrile, rapid onset of respiratory symptoms and patchy lung infiltrate, commonly have increased eosinophil percentages in BALF (>20%).…”

Section: Discussionmentioning

confidence: 98%

“…BOOP, described by EPLER et al [23], is a clinicopathological entity characterized by a granulation tissue plug within the lumen of the small airways extending into the alveolar ducts and the alveoli. The first report of interferon-α-induced BOOP [8] was diagnosed by thoracoscopic biopsy. Although four of the present cases have a compatible clinical feature and image diagnosis, histopathological findings by TBLB did not report this diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…All three subtypes have been synthesized and used clinically against chronic active viral hepatitis [4], malignancies [5], or acquired immune deficiency syndrome (AIDS) [6]. However, side-effects, such as fever, myalgia, leucopenia, nephritis [7] and bronchiolitis obliterans organizing pneumonia (BOOP) [8] or pneumonitis [9][10][11][12] have been reported. The drug "Sho-saiko-to", a composite herbal preparation, has been popularly used for the treatment of chronic hepatitis in Japan [13], as it is reputed to protect liver cells against experimentally-induced damage in vitro, to enhance the induction of plaque-forming cells, to suppress the release of arachidonic acid and leukotriene B 4 production [14], and to enhance interferon production by human peripheral blood mononuclear cells [15].…”

Section: Case Studymentioning

confidence: 99%

See 1 more Smart Citation

Pneumonitis during interferon and/or herbal drug therapy in patients with chronic active hepatitis

Ishizaki¹,

Sasaki²,

Ameshima³

et al. 1996

Eur Respir J

108

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P Pn ne eu um mo on ni it ti is s d du ur ri in ng g i in nt te er rf fe er ro on n a an nd d/ /o or r h he er rb ba al l d dr ru ug g t th he er ra ap py y i in n p pa at ti ie en nt ts s w wi it th h c ch hr ro on ni ic c a ac ct ti iv ve e h he ep pa at ti it ti is s ABSTRACT: We report four cases of acute pneumonitis due either to interferon, or a herbal drug, " "Sho-saiko-to" ", or both in combination, in patients with chronic active hepatitis, focusing on its pathogenesis and response to prednisolone therapy. These cases shared common clinical features: fever, dry cough, dyspnoea, hypoxaemia, diffuse infiltrates both on chest radiography and chest computed tomography, restrictive pulmonary functional impairment, and alveolitis on examination of transbronchial lung biopsy, all of which suggest acute interstitial pneumonia. Furthermore, lymphocytosis was observed in association with the dominant CD8+ T-cell subset in bronchoalveolar lavage fluid. A lymphocyte stimulation test using peripheral blood was positive to interferon in one case and to Sho-saiko-to in another. All patients responded to oral prednisolone therapy. Peripheral soluble interleukin-2 receptor levels decreased in parallel with improvement in the clinical course. All patients were free of symptoms with a follow-up of 1-3 yrs.We conclude that interferon-and/or Sho-saiko-to-induced acute pneumonitis may be due to allergic-immunological mechanisms rather than toxicity, and that peripheral levels of soluble interleukin-2 receptor appear to be good markers of disease activity.

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“…Ronaldo Soares Martins [1], [2] The current therapy of chronic hepatitis C is pegylated interferon (PEG-IFN) alfa-2a or -2b and ribavirin (RBV)¹. The most common side effects of interferons are cytopenias and depression.…”

Section: Secondary Bronchiolitis Obliterans Organizing Pneumonia Durimentioning

confidence: 99%

Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a

Martins

Machado

Teixeira

2012

Rev. Soc. Bras. Med. Trop.

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The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP). Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV) treatment.

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Interferon-Related Bronchiolitis Obliterans Organizing Pneumonia

Cited by 59 publications

References 5 publications

Cryptogenic organising pneumonia

Cryptogenic organising pneumonia

Pneumonitis during interferon and/or herbal drug therapy in patients with chronic active hepatitis

Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a

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