2018
DOI: 10.1016/j.jneuroim.2018.08.016
|View full text |Cite
|
Sign up to set email alerts
|

Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
5
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 10 publications
(7 citation statements)
references
References 26 publications
2
5
0
Order By: Relevance
“…A similar spike of IFNB1 expression at 2 hr post-poly(I:C) treatment was observed in human corneal epithelial cells (Kumar, Zhang, & Yu, 2006). This temporal regulation of IFNB1 expression is connected to the inherent negative feedback by downstream ISGs (Imaizumi et al, 2018).…”
Section: Type I Interferon Expression In Oral Epithelial Cells Uponsupporting
confidence: 63%
See 1 more Smart Citation
“…A similar spike of IFNB1 expression at 2 hr post-poly(I:C) treatment was observed in human corneal epithelial cells (Kumar, Zhang, & Yu, 2006). This temporal regulation of IFNB1 expression is connected to the inherent negative feedback by downstream ISGs (Imaizumi et al, 2018).…”
Section: Type I Interferon Expression In Oral Epithelial Cells Uponsupporting
confidence: 63%
“…A similar spike of IFNB1 expression at 2 hr post‐poly(I:C) treatment was observed in human corneal epithelial cells (Kumar, Zhang, & Yu, ). This temporal regulation of IFNB1 expression is connected to the inherent negative feedback by downstream ISGs (Imaizumi et al, ). The treatment, however, did not increase the expression of the type I IFN, IFNE (Figure ), that was already expressed at high levels at baseline (Table ), suggesting a different mechanism leads to a sustained expression of this type I IFN that could potentially act as a way to keep certain ISGs constitutively expressed.…”
Section: Resultsmentioning
confidence: 99%
“…15 The newly synthesized IFN-b induces the expression of IFN-stimulated genes (ISG) in an autocrine and/or a paracrine manner. 17 In the present study, we examined the effect of poly IC on the expression of CCL2 in hCMEC/D3 cells. 16 In a previous study, we found that an authentic TLR3 agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of ISG60, a member of ISG, in hCMEC/D3 cells.…”
Section: Introductionmentioning
confidence: 99%
“…16 In a previous study, we found that an authentic TLR3 agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of ISG60, a member of ISG, in hCMEC/D3 cells. 17 In the present study, we examined the effect of poly IC on the expression of CCL2 in hCMEC/D3 cells. We also examined the role of NF-jB, IRF3 and IFN-b in the regulation of CCL2 expression.…”
Section: Introductionmentioning
confidence: 99%
“…In LPS activated macrophages, Ifit1 not only supports IFN-I expression but also limits the inflammatory gene expression (17). Ifit3 negatively regulates TLR3 induced IFNβ and Cxcl10 expression in human brain endothelial cells (18). However, whether Ifit plays a role in autoimmune inflammation has not previously been examined.…”
Section: Introductionmentioning
confidence: 99%